Prions .pdf
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Prions are abnormal proteins that can cause fatal neurodegenerative diseases in humans and animals. In the 1950s, an unknown disease called "Kuru" devastated the Fore tribe in New Guinea, causing tremors, loss of motor control, and ultimately death. It was later determined that prions were responsible for Kuru and other prion diseases, which are characterized by long incubation periods, spongy changes in the brain, and neuronal loss without inflammation. Prion diseases affect the nervous system and cause changes in brain function, behavior, and cognition that progressively worsen over time from months to years until death. Causes include genetic mutations, exposure to infected tissues or during medical procedures, and consumption of beef products containing pr
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neurodegenerative diseases
1. Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis are caused by the progressive loss of structure and function of neurons in the brain and spinal cord.
2. These disorders are characterized by the abnormal deposition of misfolded proteins that form plaques and tangles within neurons, leading to neuronal dysfunction and death.
3. Common symptoms across neurodegenerative disorders include cognitive decline, psychiatric symptoms like depression, and movement problems; the specific manifestations depend on the areas of the brain affected.
Prion disease
Prion diseases are rare neurodegenerative disorders caused by misfolded prion proteins. They affect both humans and animals. In cattle it is known as bovine spongiform encephalopathy (BSE) or "mad cow disease", and in humans it is known as Creutzfeldt-Jakob disease (CJD). Prion diseases occur when normal prion proteins misfold and induce other prion proteins to also misfold, triggering a chain reaction that causes damage to neural cells. There is no cure for prion diseases and diagnosis is difficult since prion proteins are similar to normal forms.
200719058 case-study
This case study describes a 16-year-old female patient, Amy Latino, who was admitted to the hospital for status epilepticus and suicidal tendencies. Her medical history is unknown. On physical exam, she was conscious with normal vital signs. Neurological exam was normal. She has been prescribed carbamazepine 200mg twice daily to treat her seizures, with monitoring for side effects. Phenytoin may be given intravenously if needed. The case provides details on her admission, exams, medications, and nursing responsibilities.
Degenerativers
The document discusses several neurodegenerative disorders including Parkinson's disease, Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis, muscular dystrophies, herniation of intervertebral disks, and degenerative disk disease. The causes, signs and symptoms, pathophysiology, assessments, and management strategies are described for each condition. Neurodegenerative disorders are characterized by the slow deterioration of cells in the nervous system leading to progressive loss of function.
NEURODEGENERATIVE DISORDERS.
General description of neurodegenerative disorders.
Types of disorders.
Alzheimer's disease.
Parkinson's disease.
Huntington's disease.
Amyotrophic lateral sclerosis.
Tay Sachs disease.
Cause, symptoms, and treatment.
Conclusion.
Neuropsychiatric disorders
Neuropsychiatric disorders involve complex relationships between brain function and human behavior. They include anxiety, ADHD, borderline personality disorder, multiple sclerosis, Guillain-Barre syndrome, Parkinson's disease, Alzheimer's disease, progeria, and ischemia. Causes range from genetic mutations to brain damage to environmental toxins. Symptoms and treatments vary depending on the specific disorder. Neuropsychiatry aims to understand abnormal behaviors through both neurological and psychosocial factors.
Prions ppt SBC 450.ppt
Prions are infectious protein particles that cause neurodegenerative diseases like Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy (mad cow disease) in cattle. Prions are composed solely of protein and contain no nucleic acids. They propagate by converting the normal cellular prion protein (PrPC) into an abnormal disease-causing form (PrPSc). The normal prion protein is involved in the replication of the mutated form. Prion diseases are difficult to treat as prions are highly resistant to heat and chemical inactivation.
Recomendados
neurodegenerative diseases
1. Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis are caused by the progressive loss of structure and function of neurons in the brain and spinal cord.
2. These disorders are characterized by the abnormal deposition of misfolded proteins that form plaques and tangles within neurons, leading to neuronal dysfunction and death.
3. Common symptoms across neurodegenerative disorders include cognitive decline, psychiatric symptoms like depression, and movement problems; the specific manifestations depend on the areas of the brain affected.
Prion disease
Prion diseases are rare neurodegenerative disorders caused by misfolded prion proteins. They affect both humans and animals. In cattle it is known as bovine spongiform encephalopathy (BSE) or "mad cow disease", and in humans it is known as Creutzfeldt-Jakob disease (CJD). Prion diseases occur when normal prion proteins misfold and induce other prion proteins to also misfold, triggering a chain reaction that causes damage to neural cells. There is no cure for prion diseases and diagnosis is difficult since prion proteins are similar to normal forms.
200719058 case-study
This case study describes a 16-year-old female patient, Amy Latino, who was admitted to the hospital for status epilepticus and suicidal tendencies. Her medical history is unknown. On physical exam, she was conscious with normal vital signs. Neurological exam was normal. She has been prescribed carbamazepine 200mg twice daily to treat her seizures, with monitoring for side effects. Phenytoin may be given intravenously if needed. The case provides details on her admission, exams, medications, and nursing responsibilities.
Degenerativers
The document discusses several neurodegenerative disorders including Parkinson's disease, Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis, muscular dystrophies, herniation of intervertebral disks, and degenerative disk disease. The causes, signs and symptoms, pathophysiology, assessments, and management strategies are described for each condition. Neurodegenerative disorders are characterized by the slow deterioration of cells in the nervous system leading to progressive loss of function.
NEURODEGENERATIVE DISORDERS.
General description of neurodegenerative disorders.
Types of disorders.
Alzheimer's disease.
Parkinson's disease.
Huntington's disease.
Amyotrophic lateral sclerosis.
Tay Sachs disease.
Cause, symptoms, and treatment.
Conclusion.
Neuropsychiatric disorders
Neuropsychiatric disorders involve complex relationships between brain function and human behavior. They include anxiety, ADHD, borderline personality disorder, multiple sclerosis, Guillain-Barre syndrome, Parkinson's disease, Alzheimer's disease, progeria, and ischemia. Causes range from genetic mutations to brain damage to environmental toxins. Symptoms and treatments vary depending on the specific disorder. Neuropsychiatry aims to understand abnormal behaviors through both neurological and psychosocial factors.
Prions ppt SBC 450.ppt
Prions are infectious protein particles that cause neurodegenerative diseases like Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy (mad cow disease) in cattle. Prions are composed solely of protein and contain no nucleic acids. They propagate by converting the normal cellular prion protein (PrPC) into an abnormal disease-causing form (PrPSc). The normal prion protein is involved in the replication of the mutated form. Prion diseases are difficult to treat as prions are highly resistant to heat and chemical inactivation.
PRIONS THE CLINICAL CURIOSITY
Prions are abnormal protein particles that can cause neurodegenerative diseases. They have a normal function in the body but can transform into an infectious form. When this happens, they induce other normal prion proteins to adopt the abnormal shape. Common prion diseases include scrapie in sheep, mad cow disease, and Creutzfeldt-Jakob disease in humans. There are currently no effective treatments for prion diseases, so prevention and diagnosis are important.
Slow virus disease
The document discusses slow virus diseases and prion diseases. It describes how Björn Sigurðsson first introduced the slow virus concept and studied diseases like maedi, visna, and scrapie in sheep. These diseases have long incubation periods and involve the central nervous system. Prion diseases like Kuru, Creutzfeldt-Jakob disease, and mad cow disease are also described, noting they involve misfolded prion proteins and have characteristics like spongiform changes in the brain. Measles virus diseases like subacute sclerosing panencephalitis are also slow virus diseases that occur due to mutations in the measles virus.
Prions
- In the 1950s, a disease called kuru was observed among the Fore people of New Guinea that caused trembling, loss of motor control, and ultimately death.
- Kuru and other transmissible spongiform encephalopathies (TSEs) are caused by prion proteins, which are unique infectious proteins that can reproduce on their own and convert normal prion proteins into the abnormal infectious form.
- Prions are extremely resistant to heat and chemicals and can survive in the environment for many years. They infect the central nervous system and cause neurodegeneration through a chain reaction that multiplies copies of the infectious prion protein.
Dementia
Dementia is a chronic syndrome that causes deterioration in cognitive abilities beyond normal aging. It is caused by brain diseases or injuries that damage or destroy nerve cells. The document discusses the anatomy and lobes of the brain, defines dementia, explores the pathophysiology and clinical manifestations such as confusion and behavioral changes. Diagnostic tests include cognitive assessments and brain imaging. Management involves both pharmacological treatments like Aricept as well as non-pharmacological approaches like a consistent routine and environment. Nurses help by addressing issues like disrupted sleep, communication problems, and infection risk. Health education focuses on diet, hygiene, medication adherence, and lifestyle factors.
BNS
Schizophrenia and intellectual disability (mental retardation) can have organic or biochemical etiologies. Schizophrenia is characterized by distortions in thinking, perception, and behavior, and is associated with abnormalities in brain structure and function as well as imbalances in neurotransmitters like dopamine. Genetic factors, complications during birth or pregnancy, and infections may contribute to changes in brain chemistry and structure. Intellectual disability is characterized by below average intelligence and lack of adaptive skills, and around 25% of cases are linked to genetic abnormalities like Down syndrome, infectious diseases during pregnancy, or environmental toxins that can damage the developing brain like mercury or lead.
PARKINSON'S DISEASE PATHOPHYSIOLOGY B.PHARM 2ND SEM.pptx
Parkinson's disease is a progressive disorder of the central nervous system that results from the loss of dopamine-producing neurons in the brain. The main symptoms are tremors, rigidity, and slowness of movement. While the exact causes are unknown, factors like genetics, environmental toxins, and aggregates of proteins in the brain have been linked to neuronal degeneration and Parkinson's disease.
Diseases caused by prions
Misfolded proteins which catalyses the refolding of the native protein into the misfolded pathogenic forms are called as Prions. They are responsible for fatal neurodegenerative diseases. Some of the neurodegenerative diseases such as Scrapie, BSE, CWD of animals and Kuru, CJD, Fatal familial insomnia of human beings are included in the presentation.
Protein misfolding diseases
An 80-year-old man presented with symptoms of Alzheimer's disease including memory loss, disorientation, difficulty completing tasks, and mood changes. Brain scans and examination of brain tissue confirmed Alzheimer's disease. Alzheimer's is caused by abnormal accumulation of tau and amyloid-beta proteins in the brain, which form plaques and tangles that damage neurons. It is diagnosed based on symptoms, cognitive tests, and brain imaging, and progresses from mild to severe impairment over time. There are medications to temporarily improve symptoms but no cure for the underlying disease process.
Prion diseases
The document discusses prion diseases, which are neurodegenerative disorders caused by abnormal prion proteins. It covers the discovery of prions, the different forms of human and animal prion diseases, and the molecular pathogenesis involving the conversion of normal prion protein (PrPc) to abnormal disease-causing prion protein (PrPsc). Clinical features of various human prion diseases like CJD are described. Diagnosis involves neuroimaging, EEG, CSF analysis and detection of PrPsc in brain tissue. Histopathology shows vacuolation, gliosis and prion plaques. Variant CJD results from eating meat from cows with BSE.
Parkinsonism
Parkinson's disease is a brain disorder that occurs when certain nerve cells in the substantia nigra die or become impaired, reducing dopamine levels. The key signs are tremors, slow movement, rigidity, and difficulty with balance. It is caused by the loss of dopamine-producing cells and presence of Lewy bodies. While there is no cure, treatment aims to manage symptoms through dopamine replacement and other drugs, as well as physical and speech therapy.
AlzheimersDisease-deepansha ppt.ppt
Alzheimer's disease is a progressive brain disorder that destroys memory and thinking skills. It is the most common cause of dementia among older adults. The main risk factor is age, with most cases occurring in people over 65 years of age. Pathologically, it is characterized by amyloid plaques and neurofibrillary tangles in the brain that lead to the loss of connections between neurons and ultimately the death of neurons. Currently, there is no cure for Alzheimer's, and available treatments can only temporarily slow the worsening of dementia symptoms. Researchers are studying new therapies targeting the underlying causes and progression of the disease.
The Aging Brain
- The aging population has spurred research into how the brain ages, as life expectancy has increased from 47 years in 1900 to over 75 years currently.
- While some mental decline does occur with age, it is generally mild for most people. Severe decline is often due to diseases like Alzheimer's rather than normal aging.
- Environmental factors like education, physical and mental activity, sleep, and diet appear to influence brain aging, with stimulating environments and healthy behaviors linked to better cognitive functioning in old age.
Parkinson's disease
During my 1st &2nd year of residency period , i used to teach Anatomy and Orthopaedics for foreign undergraduate medical students. At last year i taught Neurology for one batch. so i posted some of my collections for competely educational purpose coz i believe in knowledge ...inseted of deleting these ppts , they may me useful for others so i shared it ....
Prion diseases
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are progressive neurodegenerative conditions caused by misfolded prion proteins. Prions can arise spontaneously or be inherited through mutations. Once in the brain, normal prion proteins are converted to the abnormal shape. This causes them to accumulate and destroy neurons, resulting in sponge-like holes in the brain tissue. Some examples of prion diseases include Creutzfeldt-Jakob disease in humans, mad cow disease in cattle, and scrapie in sheep and goats.
Multiple sclerosis
This presentation provides an overview of multiple sclerosis (MS). It defines MS as an immune-mediated demyelinating disease of the central nervous system where myelin is destroyed. Symptoms can include sensory and mobility issues as well as cognitive and psychological problems. Diagnosis involves MRI, lumbar puncture, and evoked potential studies. Management focuses on symptomatic treatment and disease-modifying drugs. Nursing care aims to improve mobility and elimination while preventing injury through safety measures and assistive devices. Recent studies examine cognitive dysfunction in MS and its effects on daily living.
Neurodegenerative disease
There are extensive number of neurodegenerative diseases but i have briefly discuss about the eight disease conditions. Hopefully it will be helpful to prospect learner. Good Luck
Understanding the Brain.pptx
Kuru is a rare, fatal prion disease endemic to Papua New Guinea that was spread through ritualistic cannibalism. It results in tremors, lack of coordination, emotional instability, and ultimately death within two years. Kuru causes neuronal vacuoles, damages the cerebellum and myelin sheaths, and forms amyloid plaques. While incurable, cases have declined due to a ban on cannibalism, with the last known death between 2005-2009. Understanding prion diseases like Kuru provides insight into neurodegeneration.
Sleep deprivation effects
Today more and more people face sleep deprivation, caused mostly by stress, lots of work and other factors. Here you find more about this subject and few strategies to overcome sleep deprivation.
SAR of Medicinal Chemistry 1st by dk.pdf
In this presentation include the prototype drug SAR on thus or with their examples .
Syllabus of Second Year B. Pharmacy
2019 PATTERN.
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
学校原件一模一样【微信：741003700 】《(salfor毕业证书)索尔福德大学毕业证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原。
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
【主营项目】
一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
Más contenido relacionado
Similar a Prions .pdf
PRIONS THE CLINICAL CURIOSITY
Prions are abnormal protein particles that can cause neurodegenerative diseases. They have a normal function in the body but can transform into an infectious form. When this happens, they induce other normal prion proteins to adopt the abnormal shape. Common prion diseases include scrapie in sheep, mad cow disease, and Creutzfeldt-Jakob disease in humans. There are currently no effective treatments for prion diseases, so prevention and diagnosis are important.
Slow virus disease
The document discusses slow virus diseases and prion diseases. It describes how Björn Sigurðsson first introduced the slow virus concept and studied diseases like maedi, visna, and scrapie in sheep. These diseases have long incubation periods and involve the central nervous system. Prion diseases like Kuru, Creutzfeldt-Jakob disease, and mad cow disease are also described, noting they involve misfolded prion proteins and have characteristics like spongiform changes in the brain. Measles virus diseases like subacute sclerosing panencephalitis are also slow virus diseases that occur due to mutations in the measles virus.
Prions
- In the 1950s, a disease called kuru was observed among the Fore people of New Guinea that caused trembling, loss of motor control, and ultimately death.
- Kuru and other transmissible spongiform encephalopathies (TSEs) are caused by prion proteins, which are unique infectious proteins that can reproduce on their own and convert normal prion proteins into the abnormal infectious form.
- Prions are extremely resistant to heat and chemicals and can survive in the environment for many years. They infect the central nervous system and cause neurodegeneration through a chain reaction that multiplies copies of the infectious prion protein.
Dementia
Dementia is a chronic syndrome that causes deterioration in cognitive abilities beyond normal aging. It is caused by brain diseases or injuries that damage or destroy nerve cells. The document discusses the anatomy and lobes of the brain, defines dementia, explores the pathophysiology and clinical manifestations such as confusion and behavioral changes. Diagnostic tests include cognitive assessments and brain imaging. Management involves both pharmacological treatments like Aricept as well as non-pharmacological approaches like a consistent routine and environment. Nurses help by addressing issues like disrupted sleep, communication problems, and infection risk. Health education focuses on diet, hygiene, medication adherence, and lifestyle factors.
BNS
Schizophrenia and intellectual disability (mental retardation) can have organic or biochemical etiologies. Schizophrenia is characterized by distortions in thinking, perception, and behavior, and is associated with abnormalities in brain structure and function as well as imbalances in neurotransmitters like dopamine. Genetic factors, complications during birth or pregnancy, and infections may contribute to changes in brain chemistry and structure. Intellectual disability is characterized by below average intelligence and lack of adaptive skills, and around 25% of cases are linked to genetic abnormalities like Down syndrome, infectious diseases during pregnancy, or environmental toxins that can damage the developing brain like mercury or lead.
PARKINSON'S DISEASE PATHOPHYSIOLOGY B.PHARM 2ND SEM.pptx
Parkinson's disease is a progressive disorder of the central nervous system that results from the loss of dopamine-producing neurons in the brain. The main symptoms are tremors, rigidity, and slowness of movement. While the exact causes are unknown, factors like genetics, environmental toxins, and aggregates of proteins in the brain have been linked to neuronal degeneration and Parkinson's disease.
Diseases caused by prions
Misfolded proteins which catalyses the refolding of the native protein into the misfolded pathogenic forms are called as Prions. They are responsible for fatal neurodegenerative diseases. Some of the neurodegenerative diseases such as Scrapie, BSE, CWD of animals and Kuru, CJD, Fatal familial insomnia of human beings are included in the presentation.
Protein misfolding diseases
An 80-year-old man presented with symptoms of Alzheimer's disease including memory loss, disorientation, difficulty completing tasks, and mood changes. Brain scans and examination of brain tissue confirmed Alzheimer's disease. Alzheimer's is caused by abnormal accumulation of tau and amyloid-beta proteins in the brain, which form plaques and tangles that damage neurons. It is diagnosed based on symptoms, cognitive tests, and brain imaging, and progresses from mild to severe impairment over time. There are medications to temporarily improve symptoms but no cure for the underlying disease process.
Prion diseases
The document discusses prion diseases, which are neurodegenerative disorders caused by abnormal prion proteins. It covers the discovery of prions, the different forms of human and animal prion diseases, and the molecular pathogenesis involving the conversion of normal prion protein (PrPc) to abnormal disease-causing prion protein (PrPsc). Clinical features of various human prion diseases like CJD are described. Diagnosis involves neuroimaging, EEG, CSF analysis and detection of PrPsc in brain tissue. Histopathology shows vacuolation, gliosis and prion plaques. Variant CJD results from eating meat from cows with BSE.
Parkinsonism
Parkinson's disease is a brain disorder that occurs when certain nerve cells in the substantia nigra die or become impaired, reducing dopamine levels. The key signs are tremors, slow movement, rigidity, and difficulty with balance. It is caused by the loss of dopamine-producing cells and presence of Lewy bodies. While there is no cure, treatment aims to manage symptoms through dopamine replacement and other drugs, as well as physical and speech therapy.
AlzheimersDisease-deepansha ppt.ppt
Alzheimer's disease is a progressive brain disorder that destroys memory and thinking skills. It is the most common cause of dementia among older adults. The main risk factor is age, with most cases occurring in people over 65 years of age. Pathologically, it is characterized by amyloid plaques and neurofibrillary tangles in the brain that lead to the loss of connections between neurons and ultimately the death of neurons. Currently, there is no cure for Alzheimer's, and available treatments can only temporarily slow the worsening of dementia symptoms. Researchers are studying new therapies targeting the underlying causes and progression of the disease.
The Aging Brain
- The aging population has spurred research into how the brain ages, as life expectancy has increased from 47 years in 1900 to over 75 years currently.
- While some mental decline does occur with age, it is generally mild for most people. Severe decline is often due to diseases like Alzheimer's rather than normal aging.
- Environmental factors like education, physical and mental activity, sleep, and diet appear to influence brain aging, with stimulating environments and healthy behaviors linked to better cognitive functioning in old age.
Parkinson's disease
During my 1st &2nd year of residency period , i used to teach Anatomy and Orthopaedics for foreign undergraduate medical students. At last year i taught Neurology for one batch. so i posted some of my collections for competely educational purpose coz i believe in knowledge ...inseted of deleting these ppts , they may me useful for others so i shared it ....
Prion diseases
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are progressive neurodegenerative conditions caused by misfolded prion proteins. Prions can arise spontaneously or be inherited through mutations. Once in the brain, normal prion proteins are converted to the abnormal shape. This causes them to accumulate and destroy neurons, resulting in sponge-like holes in the brain tissue. Some examples of prion diseases include Creutzfeldt-Jakob disease in humans, mad cow disease in cattle, and scrapie in sheep and goats.
Multiple sclerosis
This presentation provides an overview of multiple sclerosis (MS). It defines MS as an immune-mediated demyelinating disease of the central nervous system where myelin is destroyed. Symptoms can include sensory and mobility issues as well as cognitive and psychological problems. Diagnosis involves MRI, lumbar puncture, and evoked potential studies. Management focuses on symptomatic treatment and disease-modifying drugs. Nursing care aims to improve mobility and elimination while preventing injury through safety measures and assistive devices. Recent studies examine cognitive dysfunction in MS and its effects on daily living.
Neurodegenerative disease
There are extensive number of neurodegenerative diseases but i have briefly discuss about the eight disease conditions. Hopefully it will be helpful to prospect learner. Good Luck
Understanding the Brain.pptx
Kuru is a rare, fatal prion disease endemic to Papua New Guinea that was spread through ritualistic cannibalism. It results in tremors, lack of coordination, emotional instability, and ultimately death within two years. Kuru causes neuronal vacuoles, damages the cerebellum and myelin sheaths, and forms amyloid plaques. While incurable, cases have declined due to a ban on cannibalism, with the last known death between 2005-2009. Understanding prion diseases like Kuru provides insight into neurodegeneration.
Sleep deprivation effects
Today more and more people face sleep deprivation, caused mostly by stress, lots of work and other factors. Here you find more about this subject and few strategies to overcome sleep deprivation.
Similar a Prions .pdf (19)
PARKINSON'S DISEASE PATHOPHYSIOLOGY B.PHARM 2ND SEM.pptx
PARKINSON'S DISEASE PATHOPHYSIOLOGY B.PHARM 2ND SEM.pptx
Último
SAR of Medicinal Chemistry 1st by dk.pdf
In this presentation include the prototype drug SAR on thus or with their examples .
Syllabus of Second Year B. Pharmacy
2019 PATTERN.
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
学校原件一模一样【微信：741003700 】《(salfor毕业证书)索尔福德大学毕业证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原。
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
【主营项目】
一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
Katherine Romanak - Geologic CO2 Storage.pdf
Presented at June 6-7 Texas Alliance of Groundwater Districts Business Meeting
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
Ozturkcan, S., Berndt, A., & Angelakis, A. (2024). Mending clothing to support sustainable fashion. Presented at the 31st Annual Conference by the Consortium for International Marketing Research (CIMaR), 10-13 Jun 2024, University of Gävle, Sweden.
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...Advanced-Concepts-Team
Presentation in the Science Coffee of the Advanced Concepts Team of the European Space Agency on the 07.06.2024.
Speaker: Diego Blas (IFAE/ICREA)
Title: Gravitational wave detection with orbital motion of Moon and artificial
Abstract:
In this talk I will describe some recent ideas to find gravitational waves from supermassive black holes or of primordial origin by studying their secular effect on the orbital motion of the Moon or satellites that are laser ranged.Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
The binding of cosmological structures by massless topological defects
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
Micronuclei test.M.sc.zoology.fisheries.
Current Ms word generated power point presentation covers major details about the micronuclei test. It's significance and assays to conduct it. It is used to detect the micronuclei formation inside the cells of nearly every multicellular organism. It's formation takes place during chromosomal sepration at metaphase.
Randomised Optimisation Algorithms in DAPHNE
Slides from talk:
Aleš Zamuda: Randomised Optimisation Algorithms in DAPHNE .
Austrian-Slovenian HPC Meeting 2024 – ASHPC24, Seeblickhotel Grundlsee in Austria, 10–13 June 2024
https://ashpc.eu/
The cost of acquiring information by natural selection
This is a short talk that I gave at the Banff International Research Station workshop on Modeling and Theory in Population Biology. The idea is to try to understand how the burden of natural selection relates to the amount of information that selection puts into the genome.
It's based on the first part of this research paper:
The cost of information acquisition by natural selection
Ryan Seamus McGee, Olivia Kosterlitz, Artem Kaznatcheev, Benjamin Kerr, Carl T. Bergstrom
bioRxiv 2022.07.02.498577; doi: https://doi.org/10.1101/2022.07.02.498577
Immersive Learning That Works: Research Grounding and Paths Forward
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
8.Isolation of pure cultures and preservation of cultures.pdf
Isolation of pure culture, its various method.
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Basics of crystallography, crystal systems, classes and different forms
Basics of crystallography, crystal systems, classes and different forms
aziz sancar nobel prize winner: from mardin to nobel
aziz sancar nobel prize winner: from mardin to nobel
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
The binding of cosmological structures by massless topological defects
The binding of cosmological structures by massless topological defects
The cost of acquiring information by natural selection
The cost of acquiring information by natural selection
Immersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths Forward
8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf
Prions .pdf
- 1. Topic: Prions Subject: Genetics Unit 4. Teacher: M. S. Iris Cristina López Santillán.
- 2. What are Prions? They are abnormal proteins called prion proteins pathogenic agents Normal prion proteins Abundantly in the brain. Functions are not completely understood.
- 3. . In the1950s New Guinea Fatal disease on people of the Fore tribe. “Kuru” "trembling in fear." Becoming unable to walk, Lost the ability to swallow or chew. Drastic weight loss Inevitably lead to death. Prions are the responsible.
- 4. Prion diseases A family of rare progressive neurodegenerative disorders Affecting humans and animals. They are distinguished by: long incubation periods, characteristic spongiform changes associated with neuronal loss, Failure to induce inflammatory response. Normal brain tissue Spongiform encephalitis
- 5. The abnormal folding of the prion proteins leads to brain damage and the characteristic signs and symptoms of the disease.
- 9. Prion disease Affect the nervous system. In people: Impair brain function, Changes in memory, personality, and behavior; Decline in intellectual function (dementia); Abnormal movements, difficulty with coordinating movements (ataxia). Typically starts in adulthood and worsen with time, Leading to death within a few months to several years. Approximately 350 new cases are reported annually in the United States.
- 10. Causes of prion diseases 10 and 15% by mutations in the PRNP gene. 85 to 90 % are sporadic or acquired. Acquired results from exposure to PrPSc from an outside source. from eating beef products containing PrPSc Individuals ate affected human tissue during cannibalistic funeral rituals. Iatrogenic. 1 to2% can be transmitted by accidental exposure to PrPSc-contaminated tissues during a medical procedure.
- 12. Bibliography The Johns Hopkins University. (2019) Prion Diseases. Retrieved from https://www.hopkinsmedicine.org/health/conditio ns-and-diseases/prion-diseases Centers for Disease Control and Prevention. (2019) Prion Diseases. Retrieved from https://www.cdc.gov/prions/index.html