Seminario Biología Molecular Sebastian Arango Giraldo
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This document discusses a study examining the estrogen-related receptor alpha (ESRRA) and its role in cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates transcription of metabolic genes involved in mitochondrial turnover and autophagy. The study uses techniques like immunohistochemistry, RNA extraction and quantitative real-time PCR (qPCR), and massively parallel RNA sequencing to analyze ESRRA expression levels and detect variants in alternative RNA splicing, polymorphisms, or new transcripts. The results and discussion sections are not included.
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- 1. Sebastián Arango Giraldo Third Semester of Medicine Universidad Pontificia Bolivariana
- 2. Estrogen-Related Receptor INTRODUCTION The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy.
- 3. Inflammation in the Kidney Kidney inflammation can be due to various conditions such as nephritis, pyelonephritis, glomerulonephritis, or IgA nephropathy. These conditions involve inflammation in the kidneys and may be related to infections, autoimmune disorders, or other diseases, where proteins or ions are lost through the urine.
- 4. OBJETIVE
- 5. PCR RTQ es un método estándar para detectar y cuantificar una secuencia diana específica, o para cuantificar los niveles de expresión génica en una muestra. En el estudio los niveles de expresión de los genes diana se normalizaron al nivel de 18S. Por lo que se tomaron estos genes de referencia para corregir las variaciones experimentales. MÉTODOS Inmunohistoquimica Extracción de ARN y PCR cuantitativa en tiempo real (PCR RTQ)
- 6. MÉTODOS La secuenciación de ARN utiliza la capacidad de los instrumentos de secuenciación masiva, no sólo para cuantificar expresión génica, sino también para detectar variantes en el procesado alternativo del ARN, polimorfismos o nuevos transcritos. Secuenciación Masiva de ARN Análisis de Western Blot
- 7. RESULTADOS
- 8. RESULTADOS
- 9. DISCUSSION AUTHOR STATEMENT AGREE OR DISAGREE Jankauskas SS et al. (2018) “Dysregulated mitochondrial functioning has been widely studied in aging kidneys” Scarpulla RC (2008) “RNA-sequencing data suggest that Tfam mRNA levels are decreased in aging kidney, which were verified herein by real-time quantitative PCR. TFAM is a key regulator of mitochondrial gene expression” Campbell CT et al. (2012) “And is crucial for maintaining mtDNA structure, transcription, and replication”
- 10. • The research in molecular biology is important in the medical field because it allows the identification of specific genes, proteins, and signaling pathways involved in the inflammatory response of the kidney and other tissues. • Molecular biology contributes to understanding the interaction between genetic and environmental factors in the predisposition, onset, and progression of inflammatory kidney diseases.