We have strong evidence that alpha-lipoic acid supplements help with type 2 diabetes. Several studies have found that they can improve insulin resistance. Studies also found that alpha-lipoic acid supplements can help with neuropathy -- nerve damage -- caused by diabetes or cancer treatment.
Alpha-lipoic acid is an antioxidant that is useful in treating neuropathy caused by diabetes or cancer treatment. It's said to lower blood sugar levels, improve nerve function, and relieve uncomfortable symptoms in the legs and arms such as: pain. itching.
Metabolic syndrome: a pathological condition characterized by obesityAnar Niftaliyev
Metabolic syndrome: a pathological condition characterized by central (abdominal) obesity, impaired glucose homeostasis and metabolism, dyslipidemia, and arterial hypertension.
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
Alpha-lipoic acid is an antioxidant that is useful in treating neuropathy caused by diabetes or cancer treatment. It's said to lower blood sugar levels, improve nerve function, and relieve uncomfortable symptoms in the legs and arms such as: pain. itching.
Metabolic syndrome: a pathological condition characterized by obesityAnar Niftaliyev
Metabolic syndrome: a pathological condition characterized by central (abdominal) obesity, impaired glucose homeostasis and metabolism, dyslipidemia, and arterial hypertension.
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
This article is all about what AI trends will emerge in the field of creative operations in 2024. All the marketers and brand builders should be aware of these trends for their further use and save themselves some time!
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...Applitools
During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59
Key takeaways:
• Learn how to use ChatGPT to add AI power to your testing and test automation
• Understand the limitations of the technology and where human expertise is crucial
• Gain insight into different AI-based tools
• Adopt AI-based tools to stay relevant and optimize work for developers and testers
* ChatGPT and OpenAI belong to OpenAI, L.L.C.
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
This article is all about what AI trends will emerge in the field of creative operations in 2024. All the marketers and brand builders should be aware of these trends for their further use and save themselves some time!
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...Applitools
During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59
Key takeaways:
• Learn how to use ChatGPT to add AI power to your testing and test automation
• Understand the limitations of the technology and where human expertise is crucial
• Gain insight into different AI-based tools
• Adopt AI-based tools to stay relevant and optimize work for developers and testers
* ChatGPT and OpenAI belong to OpenAI, L.L.C.
4. Sağlam toxuma Diabetlə əlaqədar
metabolik və ya
vaskulyar şərtlər
kapilyarların
zədələnməsinə
yol açır
Zədə - mütləq
hissiyatın
itməsi deməkdir
Kapilyarların
zədələnməsi –
sinir zədələnməsi
aparır, bu xüsusilə
aşağı ətraflarda
hissiyatın itməsilə
müşahidə edilir
Hissiyatın
itməsi və sirkulyasiya
problemləri nəticədə
infeksiya, xora və
qanqrena riskini
artırır
MÜALİCƏ
1. Patogenetik faktor: Mütəmadı olaraq qanda qlükoza miqdarı təyin edilməli və normada saxlanılmalıdır
2. Simptomatik terapiya: Zədələnmiş sinir toxumalarına təsir təsir edərək neyropatiyanın qarşısının alınması
5.
6.
7. - İnsulinə rezistentliyi
aradan qaldırır
- Qanda şəkərin
səviyyəsini azaldır
- Qara ciyərdə qlikogen
səviyyəsini artırır
Alfa lipoy turşusunun effektivliyi çox saylı təhqiqatlar
(ALADİN, ALADİN2, ALADİN3, ORPİL, DEKAN, SYDNEY, SYDNEY2, NATHAN, NATHAN2)
və çoxillik təcrübə ilə sübüt edilmişdir.
Tioqamma
TƏ
Təsir mexanizmi
8. Ən güclü antioksidantdır: qlütation ehtiyatını bərpa edir, hüceyrələrin mitoxondrial
zədələnməsi və nekrozunun qarşısını alır 1, 2
Thiogamma® TURBO-nun tərkibinə daxil olan tiokt turşusunun meqlümin duzu
infuziya zamanı daha üstün keçiriciliyi təmin edir, eyni zamanda allergiya və nekrozun
yaranma riskini istisna edir 2, 3, 4
Karbohidrat mübadiləsində birbaşa iştirak edərək (Krebs dövründə) mitoxondrial
fermentləri aktivləşdirir, qlükoza nəqlini təmin edir, insulinə həssaslığı artırır 1, 6
Diabetik kardiomoipatiyanın qarşısını alır, mikrosirkulyasiya sistemi və damar divarının
endotelial toxumadan asılı reaksiyalarını yaxşılaşdırır, lipidlərin peroksidləşməsinin qarşısın alır,
NF-κB transkripsiya faktorunun aktivasiyasını təmin edir 5, 6, 7
həm patogenezə
həm də simptomatikaya təsir edir
9. həm patogenezə
həm də simptomatikaya təsir edir
• Qanda xolesterin və doymuş yağ turşularının səviyyəsini
azaldaraq aterosklerozun qarşısın alır 8
• Diabetik nefropatiya zamanı böyrək böyüməsini önləyir, zülalın
sidiyə keçməsinin qarşısın alır9, 10
• Güclü hepatoprotektor təsirə malikdir: qara ciyərin infeksion və
toksiki zədələnməsi zamanı hepatosidlər tərəfindən azot oksidi
sintezinin qarşısın alaraq periferik qan dövranını yaxşılaşdırır11
• HEB-i asan keçir və işemiya zamanı neyronların məhv olması eləcə də
beyində lipidlərin peroksid oksidləşməsinin qarşısın alır12
Ədəbiyyat:
1.Gregus, Z. Effects of lipoic acid on biliary excretion of glutatione and metals / Z. Gregus, A. Stein [etal.] // Toxicol Appl Pharmacol. - 1992. - № 114. - P. 88-96.
2.Ou, P. Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? / P. Ou, H. Tristschler [etal.] // Biochem Pharm. - 1995. - № 50. - P. 123-126.
3.Kempler, P. Neuropathies. Pathomechanism, clinical presentation, diagnosis, therapy / Ed. By P. Kemple. — Budapest : Springer, 2002. 208p.
4.Andreassen CS, Jakobsen J, Andersen H. Muscle Weakness – A Progressive Late Complication in Diabetic Distal Symmetric Polyneuropathy. Diabetes 2006, 55:806–812.
5.Hegazy SK, Tolba OA, Mostafa TM, Eid MA, El-Afify DR. Alpha-lipoic acid improves subclinical left ventricular dysfunction in asymptomatic patients with type 1 diabetes. Rev Diabet Stud. 2013 Spring;10(1)
6.Мохорт Т.В. Альфа-липоевая кислота: полефакторное влияние и обоснование возможностей использования при сахарном диабете //Медуцинские новости.- 2011.- №3.- С. 67-71.
7.Nebbioso M, Pranno F, Pescosolido N. Lipoic acid in animal models and clinical use in diabetic retinopathy //Expert Opin Pharmacother.- 2013.- Sep;14(13).-P.1829-1838.
8.Шульпекова, Ю.О. Применение тиоктовой кислоты в гастроэнтерологии / Ю.О. Шульпекова,В.Т. Ивашкин // РМЖ. - 2000. - Т. 8, № 15, 16.
9.Feng B, Yan XF, Xue JL, Xu L, Wang H. The protective effects of α-lipoic acid on kidneys in type 2 diabetic Goto-Kakisaki rats via reducing oxidative stress İnternational journal of molecular sciences 2013 Mar 26;14(4)
10.Brian Siu, Jharna Saha, William E Smoyer, Kelli A Sullivan, and Frank C Brosius Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: Prevention by lipoic acid treatment BMC Nephrology 2006; 7:6.
11.Козачок, Н.Н. Применение липоевой кислоты в клинической практике / Н.Н. Козачок, М.Н. Селюк / / Мистецтво лжування. - 2003. - № 5. - С. 75-77.
12.Kempler, P. Neuropathies. Pathomechanism, clinical presentation, diagnosis, therapy / Ed. By P. Kemple. — Budapest : Springer, 2002. 208p.
10. Farmakokinetikası
Sorulması
Daxilə qəbulu zamanı MBT –dən tez və tam sorulur, qida ilə birqə qəbulu
sorulmanı azaldır.
Metabolizm və xaric edilməsi.
Biomənimsənilməsi – qara ciyərdən ilkin keçid effekti nəticəsində 30-60%
təşkil edir. Cmax (6 mkq/ml) –təmini 30 dəqiqə.Т1/2 - 25 dəq.
Лекарственное взаимодействие
Тиоктовая кислота усиливает противовоспалительное действие ГКС.
При одновременном назначении тиоктовой кислоты
и цисплатина отмечается снижение эффективности цисплатина.
Тиоктовая кислота связывает металлы, поэтому ее не следует
назначать одновременно с препаратами, содержащими металлы
(например, препаратами железа, магния, кальция) - интервал между
приемами должен составлять не менее 2 ч.
При одновременном применении тиоктовой кислоты и инсулина или
пероральных гипогликемических препаратов их действие может
усиливаться.
Этанол и его метаболиты ослабляют действие тиоктовой кислоты.
11. Farmakokinetikası
Sorulması və paylanması
Venadaxili tədbiqi zamanı Cmax 10-11 dəqiqə - təxmini 20 mkq/ml. Qara ciyərdə
«ilkin keçid» effektinə məruz qalır.
Metabolizm və xaric edilməsi.
Plazma klirensi 10-15 ml/dəq təşkil edir. Metabolitləri 80-90% böyrək vasitəsi ilə
xaric edilir. .Т1/2 - 25 мин.
Лекарственное взаимодействие
Тиоктовая кислота снижает эффективность цисплатина при одновременном
приеме, а также вступает в реакцию с металлсодержащими препаратами,
такими как препараты железа, магния.
Тиоктовая кислота вступает в реакцию с молекулами сахаров, образуя
труднорастворимые комплексы, например, с раствором левулозы (фруктозы).
Усиливает противовоспалительное действие ГКС.
Инфузионный раствор тиоктовой кислоты несовместим с раствором
декстрозы, раствором Рингера и с растворами, реагирующими с
дисульфидными и SH-группами.
При одновременном применении тиоктовой кислоты и инсулина или
пероральных гипогликемических препаратов их действие может усиливаться.
Этанол и его метаболиты ослабляют действие тиоктовой кислоты.
В случае, если пациент уже принимает другие препараты или собирается их
принимать, перед приемом препарата Тиогамма необходимо
проконсультироваться с врачом.
12. DİABETİK NEYROPATİYANIN MÜALİCƏ SXEMİ
(Маньковський Б. М., 2009)
2-4 ay
1-2 ay
Diabetik neyropatiyanın orta ağırlıqlı forması
TİOQAMMA TURBO
Hazır infuziya
MİLQAMMA
Inyeksiya
600 mq - 50 ml/gündə
1 dəfə/Venadaxili
1 ampul/gündə 1 dəfə
Əzələdaxili
10-15 gün
1-2 tablet/gündə 1
dəfə, Peroral, ac qarına
1 tablet/gündə
1 dəfə Peroral
10 gün
TİOQAMMA
tablet
milgamma® protekt
tablet
TİOQAMMA
tablet
MİLQAMMA PROTEKT
tablet
1 tablet /gündə 1 dəfə
Peroral, ac qarına
1 tablet /gündə 1 dəfə
Peroral
SONRA
SONRA
2 ay
1 ay
Diabetik neyropatiyanın yüngül forması
900-3600 mq/sut/3 dəfə
Müalicə birbaşa 900 mq dozadan (gündə 3 dəfə) başlanıla bilər və ya aşağıdakı sxemə uyğun olaraq 3 ğün ərzində qəbul
ediləcək dozanı 900 mq –a çatdırmaq mümkündür:
1-ci gün: 300 mq/sutkada 1 dəfə 2-ci gün: 300 mq/sutkada 2 dəfə 3-cü gün: 300 mq/sutkada 3 dəfə
Qabaqamma 300
13. 2-4 ay
Diabetik neyropatiyanın ağır forması
TİOQAMMA TURBO HAZIR İNFUZİYA
MİLQAMMA INYEKSIYA
600-1200 mq/gündə
Venadaxili
1 ampul/gündə 1 dəfə Əzələdaxili
10-15 gün
10-15 gün 10-15 gün
1-3 tablet /gündə,
Peroral, ac qarına
TİOQAMMA tablet
SONRA
900-3600 mq/sut/3 dəfə
Müalicə birbaşa 900 mq dozadan (gündə 3 dəfə) başlanıla bilər və ya aşağıdakı sxemə uyğun olaraq 3 ğün ərzində
qəbul ediləcək dozanı 900 mq –a çatdırmaq mümkündür:
1-ci gün: 300 mq/sutkada 1 dəfə 2-ci gün: 300 mq/sutkada 2 dəfə 3-cü gün: 300 mq/sutkada 3 dəfə
Qabaqamma 300
1-2 ay
milgamma® protekt 1-2 tablet/gündə, Peroral
DİABETİK NEYROPATİYANIN MÜALİCƏ SXEMİ
(Маньковський Б. М., 2009)
MİLQAMMA NA
1 ampul/gündə 1 dəfə Venadaxili