This document advertises an upcoming one-day masterclass on adaptive designs for clinical trials hosted by Cytel. The masterclass will cover key concepts in clinical trial designs, different adaptive design options and their benefits, and how to visualize and evaluate design characteristics using East software. It is intended for medical officers, biostatisticians, and clinical team members who want to learn about design options beyond standard designs and consider more flexible approaches. The agenda includes presentations and workshops on group sequential designs, adaptive designs, and features of the East software. The event will be led by Pantelis Vlachos and takes place on December 2nd in Central London.

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GROUP DISCOUNTS AVAILABLE
SMi MASTERCLASS SERIES 2014
SMi Training Presents....
Adaptive Designs: Concepts
and Practical Considerations
for Implementation
Hosted By: Pantelis Vlachos, Director of Strategic Consulting, Cytel
Overview:
As clinical development teams are working in an increasingly pressured and complex environment,
they are looking toward different types of trial designs to address their development challenges. This
course will present key concepts in clinical trial designs, different types of design options (with a focus
on adaptive designs), and their benefits as well as possible complexities. The trainer will employ East
software as a design interface, demonstrating how the clinical team can visualize and evaluate the
key operating characteristics of a design. Wherever possible, case examples from recent clinical
trials will be used to help illustrate concepts and real-world application of the designs.
Why you should attend this Masterclass:
This workshop is intended for medical officers, biostatisticians, and core members of the clinical team
who would like to better understand the range of trial designs available to them, and which are
accepted by regulators. It will enable them to look beyond off-the-shelf designs and to consider
options which would allow for patient savings, built-in flexibility, improved knowledge-return from a
study, and an earlier time-to-market. The workshop will also inform the participants about methods
they can use to better forecast the outcomes of a trial, and monitoring tools that can help them
plan or adjust to trial changes.
MC 402
2014
2nd
Central London
DEC

2. www.smi-online.co.uk/adaptive-designs.asp
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GROUP DISCOUNTS AVAILABLE
Adaptive Designs: Concepts and Practical
Considerations for Implementation
8.30 Registration and Coffee
9.00 Introduction to East Trial Design
(Including Workshop)
10.30 Morning Coffee
10.45 Group Sequential Designs
(Including Workshop II)
12.30 Networking Lunch
13.00 Group sequential designs
(Workshop Continued)
13.30 Adaptive Designs
14.30 Afternoon Tea
14.45 Adaptive Designs
(Including Workshop III)
15.45 Further Features of East
16.00 End of Masterclass
FULL DAY PROGRAMME
About your masterclass leader:
Pantelis is a Director of Strategic Consulting for Cytel, Inc. based in Geneva. He joined the company in January
2013. Before that, he was a Principal Biostatistician at Merck Serono as well as a Professor of Statistics at Carnegie
Mellon University for 12 years. His research interests lie in the area of adaptive designs, mainly from a Bayesian
perspective, as well as hierarchical model testing and checking although his secret passion is Text Mining. He is
the Managing Editor of the journal “Bayesian Analysis” and has served in the editorial boards of several other
journals and online statistical data and software archives.
About the Organisation:
Cytel offers a broad range of high-quality, flexible and cost-effective solutions to support
all phases of drug, biologic and device development. We provide our customers with
unrivaled knowledge in biostatistics and operations research for software development,
strategic consulting and clinical research services. We combined this knowledge with our trial implementation
capabilities, to help our customers uphold the highest standards of scientific rigor, statistical validity, and data
quality in all of our engagements.

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ADAPTIVE DESIGNS: CONCEPTS AND PRACTICAL
CONSIDERATIONS FOR IMPLEMENTATION
Tuesday 2nd December 2014, Central London
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