www.medicotesting.com , AIDS ppt
•
1 recomendación•511 vistas
power point to come on www.medicotesting.com
![What is HIV DR ,[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
Recomendados
Recomendados
Más contenido relacionado
La actualidad más candente
La actualidad más candente (20)
Destacado
Destacado (19)
Similar a www.medicotesting.com , AIDS ppt
Similar a www.medicotesting.com , AIDS ppt (20)
Más de Smruti Patanaik
Más de Smruti Patanaik (20)
Último
Último (20)
www.medicotesting.com , AIDS ppt
- 1. Anti Retroviral Drug Resistance Dr Dimple Kasana Asstt. Director (R&D) National AIDS Control Organization Ministry Of Health and family welfare
- 9. Prevention of emergence of HIV Drug Resistance (HIV DR) is accorded a high priority and is a crucial component of the National ART Programme
- 17. Steering Committee Technical Committee WG WG WG WG WG HIVResNet WHO Secretariat Epidemiology Data use Technology transfer Data Management Lab T he World Health Organization has brought together a global group of experts and organizations to develop and implement surveillance and monitoring methods to support the containment of HIV drug resistance (HIVDR) as antiretroviral treatment (ART) is rolled out worldwide. A formal laboratory network with QA/QC and certification will begin this year. Each working group (WG) is co-chaired by 1 developing country expert + 1 industrialized country expert
- 25. Photo Album by abc Thank you …………………..
Notas del editor
- In an untreated person several months after infection, a relatively steady state of between 1000 and 100,000 circulating virus particles (“copies of HIV RNA) per milliliter of plasma is reached. (determined partly b y host genetics, partly by the nastiness of the infecting virus) [Genetic polymorphisms in chemokine receptors and haplotypes of the human leukocyte antigen are the best-defined host determinants] [HIV virions = mature infectious virus particles] At lest 10 million to 100 million CD4 lymphocytes are productively infected by one billion contain HIV genetic material (HIV nucleic acid). Rates of virus clearance seem similar in all pts and all disease stages, so steady state levels of circ HIV are determined by the rate of virus production. The higher the RNA levels the faster the loss of CD4 cells and the shorter the duration of HIV infection before death. CD4 count determines the risk of disease and death and the level of HIV FRNA determines the rate of CD4 cell decline. Activated CD4 lymphocytes and macs are the predominant host cells for HIV replication. Latently infected CD4 lymphocytes represent a small fraction of infected cells during active infection and have a half-life of at least 6 months. So many such cells survive for years, archiving virus that can re-emerge and propagate after the withdrawal of chemotherapy. So Infec can’t be eradicated. Rx death of infected activated cd4 lymphs and prevention of new infections. Second phase clearance may be due to infected macs or virions bound to dendritic cells in lymph nodes, and also to chronically Infec cd4 lymphs w a longer half-life and lower rates of virus replication.
- Remember that in the Netherlands transmission of resistant strains declined from > 10% to < 5% after treatment programmes improved. HIV drug resistance does not spread like wildfire.