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Managing Cancer Related Fatigue




 Megan Webster, PT, Certified Personal Trainer, Certified
 Lymphedema Therapist
 Karl Anderson, OTR/L, MOT
                         April 6th, 2013
What is cancer-related fatigue

The National Comprehensive Cancer Network definition(NCCN):


• “A distressing, persistent, subjective sense of tiredness or
  exhaustion related to cancer or cancer treatment that is not
  proportional to recent activity and interferes with usual
  functioning.”




    National Cancer Institute: PDQ Fatigue. Bethesda, MD: National Cancer Institue. Available
    at:http://cancer.gov/cancertopics/pdq/supportivecare/fatigue/HealthProfessional. Accessed March
2   24, 2013
Acute Fatigue vs. Cancer-Related Fatigue

‘Healthy’ Fatigue              Cancer-related Fatigue
• Acute                        •Chronic
• Relieved by sleep and rest   •Not completely relieved by sleep and rest
• Has an identifiable cause    •Severe
                               •Mechanism poorly understood




  3
Prevalence
• 70-100% of cancer patients are affected by CRF during
  treatment
• For 30% or more, it can linger long after treatment is
  completed
• Many people are fully functioning prior to cancer
  diagnosis
• Treatment leads to:
    − Reduced strength and endurance, fatigue, cognitive impairments
      and pain
    − Difficulty returning to previous activities and responsibilities

      Cramp F, Danial J. Exercise for the management of cancer-related fatigue in
4     adults. Cochrane Database System Review. 2008:CD006145
Fatigue Affects Quality of Life
 Daily activities affected included:

  •   Walking distances                                                •     Social activities with friends/family

  •   Cleaning the house                                               •     Climbing stairs

  •   General household chores                                         •     Running errands

  •   Getting exercise                                                 •     Taking care/meeting needs of family

  •   Straightening up the house                                       •     Concentrating on things

  •   Lifting things                                                   •     Preparing food


       Curt, GA, Breitbart, W. Impact of cancer-related fatigue on the lives of patients: new findings from
 5     the Fatigue Coalition. Oncologist. 2000;5(5):353-60.
Fatigue affecting one’s occupation and the impact
of cancer treatment on primary caregivers
 •   Accepted fewer responsibilities

 •   Reduced work hours

 •   Took days off work

 •   Stopped working altogether

 •   Went on disability

 •   Used unpaid family and medical leave time

      Curt, GA, Breitbart, W. Impact of cancer-related fatigue on the lives of patients: new findings from
      the Fatigue Coalition. Oncologist. 2000;5(5):353-60.

 6
Cancer Related Fatigue
 • Fatigue is a highly distressing symptom of cancer
      − It negatively impacts:
       • Physical performance
       • Mood
       • Social interaction
       • Cognitive performance
       • Sense of self



  7
Types of Cancer-Related Fatigue
Primary Fatigue
• Fatigue that results from the result of a disease or medical condition.
• Fatigue that is related to your diagnosis


Cancer treatments contribute to primary fatigue
    • Chemotherapy
    • Radiation
    • Surgery
    • Blood & Marrow Transplants(BMT)

        National Cancer Institute: PDQ Fatigue. Bethesda, MD: National Cancer Institue. Available
        at:http://cancer.gov/cancertopics/pdq/supportivecare/fatigue/HealthProfessional. Accessed March
        24, 2013
8
Types of Cancer-Related Fatigue
Secondary Fatigue
    -Fatigue that is a result of factors beyond your diagnosis

Contributors to secondary fatigue
    •Poor sleep                                                     •Depression/anxiety

    •Physical de-conditioning                                       •Emotional distress/stress

    •Infection                                                      •Nutrition

    •Medication side-effects

      Department of Occupational Therapy, University of Illinois-Chicago 2012

9     [Materials developed by Kara Stout]
Types of Cancer-Related Fatigue
Cognitive/mental fatigue
     -Fatigue that makes it difficult to concentrate or do activities that
     involve thinking
     -Not always obvious, but it is real
Common descriptors
•Sleepy brain                                                 •Haziness, dullness
•In a fog: cloudy thinking                                    •Total confusion
•Mind goes blank                                              •Can not think straight


        Department of Occupational Therapy, University of Illinois-Chicago 2012
        [Materials developed by Kara Stout]
10
NCCN Interventions for Fatigue
Occupational Therapy                                                   Physical Therapy
Energy Conservation                                                   Activity enhancement
  − Set priorities                                                         − Initiate endurance and
  − Pace/Delegate                                                            resistance exercise
                                                                           − Referral to PT/OT/physical
  − Scheduling
                                                                             medicine
  − Structured daily routine
                                                                      Nutrition consultation
  Psychosocial interventions
                                                                      Psychological consult
  − Educational and supportive
    therapies


  11 National Cancer Institute: PDQ Fatigue. Bethesda, MD: National Cancer Institue.
  Available at:http://cancer.gov/cancertopics/pdq/supportivecare/fatigue/HealthProfessional.
  Accessed March 24, 2013
Fairview Cancer Rehab Program

• Occupational and Physical Therapy Evaluations


  − Therapists have extensive training and experience with cancer
    survivors


  − In depth knowledge of medical records and able to adjust your
    treatments to your specific and current needs (i.e. lab values,
    precautions/contraindications)




                                                      12
PT sessions
• Individualized exercise prescription

  − Aerobic and endurance training, strength training, ROM


  − Manual therapy for myofascial restrictions, joint mobilization, and
    to decrease pain




                                                       13
American College of Sports Medicine Roundtable
  on Exercise Guidelines for Cancer Survivors
Exercise during and after cancer treatment is safe and
positively impacts:
    • Aerobic capacity
    • Quality of Life
    • Body composition
    • Fatigue
    • Strength
    • Function
•Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, et al. American College of Sports Medicine
Roundtable on Exercise Guidelines for Cancer Survivors. Medicine & Science in Sports & Exercise. 2010;42(7): 1409-
1426
OT sessions
• Occupational Therapy:


     − Energy management training
      • Planning for physical and “brain” rest break
      • Pacing, delegating


     − Cognitive compensatory strategies
      • Mapping strategies for organization of thoughts
      • Problem-solving to beak down tasks into manageable parts



15
The Fatigue Cycle




     Department of Occupational Therapy, University of Illinois-Chicago 2012
     [Materials developed by Kara Stout]
16
How to Manage Fatigue (The Basics)
          Banking and Budgeting your Energy
• Banking your energy =               • Budgeting your energy =
  saving energy when you                deciding how to spend
  can                                   your energy
•The goal is to put energy in the     •The goal is to spend energy on
bank by resting                       what is important to you

•Deposit energy by resting to         •It can be hard to decide how to
strengthen your account               use your energy

•Save energy so you can do the        •Think about your activities and
things you want and need to do        how much energy they require

•Always keep a little energy in the
bank for emergencies or special
17
occasions
Who is Fairview Cancer Rehab for?
 • Significant fatigue, diminished energy, increased need
   to rest
 • Diminished concentration or memory
 • Difficulty completing daily tasks
 • Anyone who previously exercised and has difficulty
   returning to work/leisure activities
 • Anyone who has never exercised and doesn’t know
   where to begin


                                            18
Case Study


• 46 y.o. female
• Stage IIIc R breast cancer, 16 nodes positive
• R mastectomy and Ax LND, chemo/radiation
• All treatment finished 2008
• Osteopenia, hyperlidipemia, asthma, migraines




                                             19
Case Study Continued
Impairments
• Cognitive and physical fatigue
• Cognitive changes with decreased short term
  memory
• Weakness:
 -Decreased shoulder strength
 -Decreased leg strength
 -Decreased endurance on 6 min walk test



                                           20
Case Study Continued
  Treatment: Occupational Therapy


  − Energy management training


  − Cognitive compensatory strategies




                                        21
Case Study Continued
 Treatment: Physical Therapy


 -Education on how to increase aerobic capacity without undue fatigue
   using bike and eliptical machines


 -Training in slow progression in weight lifting to avoid lymphedema and
    undue muscle soreness.


 -Myofascial release to R shoulder, upper ¼.


                                                    22
Discharge Status Fatigue Scores




                                  23
Case Study Continued
Discharge Status Physical Functioning

• 6 minute walk test at 97% of norm


• Leg press increased from 80# to 120# (90%of norm)


• Able to vacuum, carry groceries


• Returned to health club for weight lifting and aerobic workouts 3x
  week.

                                                       24
Borg’s Scale of Perceived Exertion




     Borg RPE scale
     © Gunnar Borg, 1970, 1985, 1994, 1998

25
What can you do today?
                   Begin a walking program

•Start walking once each day for 3-5 minutes, at a perceived exertion
of 11-13 (light to somewhat hard)


•Add 1-2 minutes every 3 days with a goal of 30 minutes most days of
the week. As you increase the amount of time, gradually increase your
pace so you are working at a “somewhat hard” pace with perceived
exertion of 12-14


•When you feel like you need a nap, try a short walk


26
What can you do today?

• Decrease unnecessary muscle tension


• Strengthen your legs
     -Find a chair with arms and push it up against the wall. Using your
     arms as little as possible, see how many times you can go from
     sitting to standing in 30 seconds
     -Repeat it every other day and keep track of improvement




27
28
How to access services

             Fairview Cancer Rehab
                 612-273-6228
                      &
     Managing Cancer-Related Fatigue Group
                 612-672-7272




29
Questions




30
References
 •   National Comprehensive Cancer Network: NCCN Clinical Practice Guidelines in
     Oncology: Cancer-Related Fatigue. Version 1.2010. Rockledge, Pa: National
     Comprehensive Cancer Network, 2010.Available online. Last accessed March 26,
     2013
 •   Cramp F, Danial J. Exercise for the management of cancer-related fatigue in adults.
     Cochrane Database System Review. 2008:CD006145
 •   Curt, GA, Breitbart, W. Impact of cancer-related fatigue on the lives of patients: new
     findings from the Fatigue Coalition. Oncologist. 2000;5(5):353-60.
 •   National Cancer Institute: PDQ Fatigue. Bethesda, MD: National Cancer Institue.
     Available
     at:http://cancer.gov/cancertopics/pdq/supportivecare/fatigue/HealthProfessional.
     Accessed March 24, 2013
 •   Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, et al. American
     College of Sports Medicine Roundtable on Exercise Guidelines for Cancer Survivors.
     Medicine & Science in Sports & Exercise. 2010;42(7): 1409-1426




31

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Kari Anderson, OTR/L and Megan Webster, PT

  • 1. Managing Cancer Related Fatigue Megan Webster, PT, Certified Personal Trainer, Certified Lymphedema Therapist Karl Anderson, OTR/L, MOT April 6th, 2013
  • 2. What is cancer-related fatigue The National Comprehensive Cancer Network definition(NCCN): • “A distressing, persistent, subjective sense of tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning.” National Cancer Institute: PDQ Fatigue. Bethesda, MD: National Cancer Institue. Available at:http://cancer.gov/cancertopics/pdq/supportivecare/fatigue/HealthProfessional. Accessed March 2 24, 2013
  • 3. Acute Fatigue vs. Cancer-Related Fatigue ‘Healthy’ Fatigue Cancer-related Fatigue • Acute •Chronic • Relieved by sleep and rest •Not completely relieved by sleep and rest • Has an identifiable cause •Severe •Mechanism poorly understood 3
  • 4. Prevalence • 70-100% of cancer patients are affected by CRF during treatment • For 30% or more, it can linger long after treatment is completed • Many people are fully functioning prior to cancer diagnosis • Treatment leads to: − Reduced strength and endurance, fatigue, cognitive impairments and pain − Difficulty returning to previous activities and responsibilities Cramp F, Danial J. Exercise for the management of cancer-related fatigue in 4 adults. Cochrane Database System Review. 2008:CD006145
  • 5. Fatigue Affects Quality of Life Daily activities affected included: • Walking distances • Social activities with friends/family • Cleaning the house • Climbing stairs • General household chores • Running errands • Getting exercise • Taking care/meeting needs of family • Straightening up the house • Concentrating on things • Lifting things • Preparing food Curt, GA, Breitbart, W. Impact of cancer-related fatigue on the lives of patients: new findings from 5 the Fatigue Coalition. Oncologist. 2000;5(5):353-60.
  • 6. Fatigue affecting one’s occupation and the impact of cancer treatment on primary caregivers • Accepted fewer responsibilities • Reduced work hours • Took days off work • Stopped working altogether • Went on disability • Used unpaid family and medical leave time Curt, GA, Breitbart, W. Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition. Oncologist. 2000;5(5):353-60. 6
  • 7. Cancer Related Fatigue • Fatigue is a highly distressing symptom of cancer − It negatively impacts: • Physical performance • Mood • Social interaction • Cognitive performance • Sense of self 7
  • 8. Types of Cancer-Related Fatigue Primary Fatigue • Fatigue that results from the result of a disease or medical condition. • Fatigue that is related to your diagnosis Cancer treatments contribute to primary fatigue • Chemotherapy • Radiation • Surgery • Blood & Marrow Transplants(BMT) National Cancer Institute: PDQ Fatigue. Bethesda, MD: National Cancer Institue. Available at:http://cancer.gov/cancertopics/pdq/supportivecare/fatigue/HealthProfessional. Accessed March 24, 2013 8
  • 9. Types of Cancer-Related Fatigue Secondary Fatigue -Fatigue that is a result of factors beyond your diagnosis Contributors to secondary fatigue •Poor sleep •Depression/anxiety •Physical de-conditioning •Emotional distress/stress •Infection •Nutrition •Medication side-effects Department of Occupational Therapy, University of Illinois-Chicago 2012 9 [Materials developed by Kara Stout]
  • 10. Types of Cancer-Related Fatigue Cognitive/mental fatigue -Fatigue that makes it difficult to concentrate or do activities that involve thinking -Not always obvious, but it is real Common descriptors •Sleepy brain •Haziness, dullness •In a fog: cloudy thinking •Total confusion •Mind goes blank •Can not think straight Department of Occupational Therapy, University of Illinois-Chicago 2012 [Materials developed by Kara Stout] 10
  • 11. NCCN Interventions for Fatigue Occupational Therapy Physical Therapy Energy Conservation Activity enhancement − Set priorities − Initiate endurance and − Pace/Delegate resistance exercise − Referral to PT/OT/physical − Scheduling medicine − Structured daily routine Nutrition consultation Psychosocial interventions Psychological consult − Educational and supportive therapies 11 National Cancer Institute: PDQ Fatigue. Bethesda, MD: National Cancer Institue. Available at:http://cancer.gov/cancertopics/pdq/supportivecare/fatigue/HealthProfessional. Accessed March 24, 2013
  • 12. Fairview Cancer Rehab Program • Occupational and Physical Therapy Evaluations − Therapists have extensive training and experience with cancer survivors − In depth knowledge of medical records and able to adjust your treatments to your specific and current needs (i.e. lab values, precautions/contraindications) 12
  • 13. PT sessions • Individualized exercise prescription − Aerobic and endurance training, strength training, ROM − Manual therapy for myofascial restrictions, joint mobilization, and to decrease pain 13
  • 14. American College of Sports Medicine Roundtable on Exercise Guidelines for Cancer Survivors Exercise during and after cancer treatment is safe and positively impacts: • Aerobic capacity • Quality of Life • Body composition • Fatigue • Strength • Function •Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, et al. American College of Sports Medicine Roundtable on Exercise Guidelines for Cancer Survivors. Medicine & Science in Sports & Exercise. 2010;42(7): 1409- 1426
  • 15. OT sessions • Occupational Therapy: − Energy management training • Planning for physical and “brain” rest break • Pacing, delegating − Cognitive compensatory strategies • Mapping strategies for organization of thoughts • Problem-solving to beak down tasks into manageable parts 15
  • 16. The Fatigue Cycle Department of Occupational Therapy, University of Illinois-Chicago 2012 [Materials developed by Kara Stout] 16
  • 17. How to Manage Fatigue (The Basics) Banking and Budgeting your Energy • Banking your energy = • Budgeting your energy = saving energy when you deciding how to spend can your energy •The goal is to put energy in the •The goal is to spend energy on bank by resting what is important to you •Deposit energy by resting to •It can be hard to decide how to strengthen your account use your energy •Save energy so you can do the •Think about your activities and things you want and need to do how much energy they require •Always keep a little energy in the bank for emergencies or special 17 occasions
  • 18. Who is Fairview Cancer Rehab for? • Significant fatigue, diminished energy, increased need to rest • Diminished concentration or memory • Difficulty completing daily tasks • Anyone who previously exercised and has difficulty returning to work/leisure activities • Anyone who has never exercised and doesn’t know where to begin 18
  • 19. Case Study • 46 y.o. female • Stage IIIc R breast cancer, 16 nodes positive • R mastectomy and Ax LND, chemo/radiation • All treatment finished 2008 • Osteopenia, hyperlidipemia, asthma, migraines 19
  • 20. Case Study Continued Impairments • Cognitive and physical fatigue • Cognitive changes with decreased short term memory • Weakness: -Decreased shoulder strength -Decreased leg strength -Decreased endurance on 6 min walk test 20
  • 21. Case Study Continued Treatment: Occupational Therapy − Energy management training − Cognitive compensatory strategies 21
  • 22. Case Study Continued Treatment: Physical Therapy -Education on how to increase aerobic capacity without undue fatigue using bike and eliptical machines -Training in slow progression in weight lifting to avoid lymphedema and undue muscle soreness. -Myofascial release to R shoulder, upper ¼. 22
  • 24. Case Study Continued Discharge Status Physical Functioning • 6 minute walk test at 97% of norm • Leg press increased from 80# to 120# (90%of norm) • Able to vacuum, carry groceries • Returned to health club for weight lifting and aerobic workouts 3x week. 24
  • 25. Borg’s Scale of Perceived Exertion Borg RPE scale © Gunnar Borg, 1970, 1985, 1994, 1998 25
  • 26. What can you do today? Begin a walking program •Start walking once each day for 3-5 minutes, at a perceived exertion of 11-13 (light to somewhat hard) •Add 1-2 minutes every 3 days with a goal of 30 minutes most days of the week. As you increase the amount of time, gradually increase your pace so you are working at a “somewhat hard” pace with perceived exertion of 12-14 •When you feel like you need a nap, try a short walk 26
  • 27. What can you do today? • Decrease unnecessary muscle tension • Strengthen your legs -Find a chair with arms and push it up against the wall. Using your arms as little as possible, see how many times you can go from sitting to standing in 30 seconds -Repeat it every other day and keep track of improvement 27
  • 28. 28
  • 29. How to access services Fairview Cancer Rehab 612-273-6228 & Managing Cancer-Related Fatigue Group 612-672-7272 29
  • 31. References • National Comprehensive Cancer Network: NCCN Clinical Practice Guidelines in Oncology: Cancer-Related Fatigue. Version 1.2010. Rockledge, Pa: National Comprehensive Cancer Network, 2010.Available online. Last accessed March 26, 2013 • Cramp F, Danial J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database System Review. 2008:CD006145 • Curt, GA, Breitbart, W. Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition. Oncologist. 2000;5(5):353-60. • National Cancer Institute: PDQ Fatigue. Bethesda, MD: National Cancer Institue. Available at:http://cancer.gov/cancertopics/pdq/supportivecare/fatigue/HealthProfessional. Accessed March 24, 2013 • Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, et al. American College of Sports Medicine Roundtable on Exercise Guidelines for Cancer Survivors. Medicine & Science in Sports & Exercise. 2010;42(7): 1409-1426 31

Notas del editor

  1. Introductions; Megan-posture
  2. -MEGAN
  3. KARL
  4. KARL -Often patients aren’t given education on how to return to a healthy lifestyle after treatment. -Many patients may accept decreased function as the price they have to pay for getting rid of the cancer
  5. MEGAN Telephone survey of 6, 125 households in the United States identified as having a member with cancer.  Patients reporting fatigue at least a few times a month were asked a series of questions to better describe their fatigue and its impact on quality of life. Of those reporting fatigue Ninety-one percent of those who experienced fatigue reported that it prevented a "normal" life, and 88% indicated that fatigue caused an alteration in their daily routine
  6. MEGAN Barriers: feel that it is inevitable, feel that som one would ask about it if it was important,
  7. MEGAN often under treated even tho it has a significant impact on QOL
  8. KARL
  9. KARL
  10. KARL
  11. KARL---National Comprehensive cancer network recommends these strategies.
  12. MEGAN
  13. MEGAN Aerobic assess: 6 min walk/TUG, eval soft tissue restrictions, check for lymphedema Individualized tx based on former activity level and current status. Use of Nu-step, treadmill, weight machines. 2-3 x week for some 1 x eval for others.
  14. Megan Pts told to rest…get weaker. Prescribing ex counterintuitive.. But research shows that it can reduce fatigue and improve function. You can’t sit still waiting to feel better. Am College of Sports Med released guidelines for exercise for cancer survivors for the 1 st time in July 2010. They concluded that exercise is safe during and after tx for cancer and that it positively impacts: aerobic…qol…
  15. KARL
  16. MEGAN
  17. MEGAN
  18. KARL/MEGAN(weakness) Multi dimensional Fatigue Inventory score looks at 3 types of fatigue
  19. KARL
  20. MEGAN
  21. KARL
  22. MEGAN
  23. MEGAN 9 corresponds to "very light" exercise. For a healthy person, it is like walking slowly at his or her own pace for some minutes 13 on the scale is "somewhat hard" exercise, but it still feels OK to continue. 17 "very hard" is very strenuous. A healthy person can still go on, but he or she really has to push him- or herself. It feels very heavy, and the person is very tired. 19 on the scale is an extremely strenuous exercise level. For most people this is the most strenuous exercise they have ever experienced. Borg RPE scale © Gunnar Borg, 1970, 1985, 1994, 1998
  24. MEGAN too fast – executive; too slow – won’ t make a difference
  25. Megan: stay independent: have strong legs
  26. MEGAN Complete BFI
  27. KARL