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Myelodysplastic Syndrome
1.
MYELODYSPLASTIC SYNDROME
2.
3.
Affect All Non-Lymphoid
Lineages
4.
Myeloblast comprise <
20% marrow cellularity
5.
6.
1. Idiopathic MDS
– insidious, over 50 y/o
7.
2. Therapy related
MDS ( t-MDS)– complication of previous genotoxic drug/radiotx. Appear 2-8 years later.
8.
ALL transform to
AML
9.
10.
S/Sx related to
pancytopenia
11.
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