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DNA Methylation Patterns & Epigenetic Regulation in the Pacific Oyster Mackenzie Gavery & Steven Roberts University of Washington School of Aquatic and Fishery Sciences
Outline ,[object Object],[object Object],[object Object],[object Object]
Background: GENES (DNA) TRAITS color growth disease resistance toxins ENVIRONMENT nutrition pathogens
GENES (DNA) EPIGENOME (DNA methylation) TRAITS color growth disease resistance toxins Background: ENVIRONMENT nutrition pathogens
GENES (DNA) EPIGENOME (DNA methylation) TRAITS color growth disease resistance toxins Background: ENVIRONMENT nutrition pathogens
Epigenetics ,[object Object],[object Object],[object Object],[object Object],[object Object],Me C G C G
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DNA methylation
Characterization of DNA methylation in Pacific oysters : ,[object Object],[object Object]
Results ,[object Object],[object Object],[object Object]
Results ,[object Object],[object Object],[object Object]
Results: gene-targeted approach ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Results ,[object Object],[object Object],[object Object]
Results ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Regulation of Gene Expression high mid low Predicted DNA Methylation
Regulation of Gene Expression high mid low Predicted DNA Methylation
Implications: ,[object Object],[object Object]
Implications: Environment Low High
[object Object],[object Object],Implications: Selective Breeding
Implications: Hybrid Vigor ,[object Object],[object Object],[object Object],[object Object],X =
Implications: Nutrition ,[object Object],Waterland & Jirtle, Molecular and Cellular Biology , 2003
Future Directions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Summary ,[object Object],[object Object],[object Object]
Acknowledgements ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Gavery PCSGA 2010

  • 1. DNA Methylation Patterns & Epigenetic Regulation in the Pacific Oyster Mackenzie Gavery & Steven Roberts University of Washington School of Aquatic and Fishery Sciences
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  • 3. Background: GENES (DNA) TRAITS color growth disease resistance toxins ENVIRONMENT nutrition pathogens
  • 4. GENES (DNA) EPIGENOME (DNA methylation) TRAITS color growth disease resistance toxins Background: ENVIRONMENT nutrition pathogens
  • 5. GENES (DNA) EPIGENOME (DNA methylation) TRAITS color growth disease resistance toxins Background: ENVIRONMENT nutrition pathogens
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  • 14. Regulation of Gene Expression high mid low Predicted DNA Methylation
  • 15. Regulation of Gene Expression high mid low Predicted DNA Methylation
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