sulfanilamide

2. ANTI-BACTERIAL
SULFANILAMIDE

3. SULFANILAMIDE:
They act as antimicrobial agents by
inhibiting bacterial growth and activity
commonly called as sulpha drugs.
It is a molecule containing the
sulfonamide group attached with
aniline.
Its molecular structure is similar to p-
Amino benzoic acid (PABA)

4. IDENTICAL STRUCTURE:

5. HISTORY:

6. SYNTHESIS :

7. BIOCHEMICAL ACTION:
Dihydripteroate synthetase catalyses
the condensation of dihydropteroate
diphosphate + (PABA) to form
dihydropteroic acid & convert into
dihydrofolic acid.
DHPS is the target of sulfonamides
which are substrate analogues that
compete with precursor p-
aminobenzoic acid.
Dihydrofolic acid converts into
tetrehydrofolic acid & inhibited by
trimethoprim

8. SULFANILAMIDE
ANTIMETABOLITES:

9. COMPETITIVE INHIBITION:

10. DERIVATIVES OF
SULFANILAMIDES:

11. DERIVATIVES :
Sulfathiazole
Furosemide

12. SULFATHIAZOLE:
Short acting sulfonamide
antibiotics used in the
treatment of infections and for
disinfecting home aquariums.
Common side effects are
itching,burning,an increased
need to urinate and allergy.

13. FUROSEMIDE:
Used to treat fluid build up by
heart failure,liver scarring or kidney
diseases,high blood pressure,cause
diuresis
Loss of blood pressure,hearing
loss,excessive use cause metabolic
alkalosis due to hypokalemia and
hypochloremia.

14. SIDE EFFECTS:
Itching,rash
Swelling of
mouth,face and
lips
Fever,chills, sore
throat etc.

15. REFERENCES:
Actor, P.; Chow, A. W.; Dutko, F. J.; McKinlay, M. A. (2005), "Chemotherapeutics", Ullmann's
Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH
Biography of Paul Gelmo: Encyclopedia.com.
Paul Gelmo (May 14, 1908) "Über Sulfamide der p-Amidobenzolsulfonsäure," Journal für
Praktische Chemie, 77 : 369-382.
 G. Domagk, "Ein Beitrag zur Chemotherapie der bakteriellen Infektionen", Deutsche
Medizinische Wochenschrift, 61, feb. 15, 1935, p. 250.
On May 18, 1909, Deutsches Reich Patentschrift number 226,239 for sulfanilamide
was awarded to Heinrich Hörlein of the Bayer corporation.