Bio-based chemicals are derived from renewable feedstock, i.e. all biomass derived from plants, animals or microorganisms (including biological waste from households, agricultural residues, and waste from animals and food/feed production), which can be used in part or as a whole as raw materials for industrial production and energy generation.
in this slides I try to speech about biobased chemicals and its products,methods and other opportunities...
2. introduction
Bio-based chemicals are derived from renewable feedstock, i.e. all biomass
derived from plants, animals or microorganisms (including biological
waste from households, agricultural residues, and waste from animals and
food/feed production), which can be used in part or as a whole as raw
materials for industrial production and energy generation.
is important to differentiate between 1st and 2nd
generation technology for the production of biofuels and
bio-based chemicals.
First generations
Second generations
3. Analysis of markets for bio-based
products
There is a wide range of bio-based products which could eventually
acquire a substantial market acceptance:
Fibre based materials (i.e. for construction sector or car industry);
Bio-plastics and other bio-polymers;
Surfactants;
Bio-solvents;
Bio-lubricants;
Ethanol and other chemicals and chemical building blocks;
Pharmaceutical products incl. vaccines;
Enzymes;
Cosmetics.
4. bio-solvents, produced from vegetable oils and from starch
progressively replace petrochemical solvents. Solvents mainly part of
paintings, inks, varnishes, adhesives etc. Majority of solvents currently
petrochemical solvents.
Biopolymers, such as polysaccharides (carbohydrates – starch from
maize, wheat, and potatoes). Polylactic Acid (PLA), a plastic material
derived by fermentation (producing lactic acid) from starches or
glucose. Used for food packaging, bags, hygiene products, packaging
for biological waste, plant pots, etc. Also composite materials with
new qualities; textiles, etc.
5. Surfactants lower surface tension of liquids and are used in
soaps, detergents, pharmaceuticals, food additives, etc. and for
the production of emulsions and foams. They are produced
largely from oils. Next generation "biosurfactants" can be
produced from algae or bacteria.
Biodegradable lubricants made from vegetable oils (and their
chemical derivatives) that are non toxic for soil or water. Used as
hydraulic oils in areas where high risk of pollution.
6. The chemicals of interest are the ones that could potentially serve as
building blocks, platforms, for other chemicals and polymers.
Glycerol, a by-product of biodiesel production, was used as raw material for
the production of propionic acid, 3-hydroxypropionaldehyde (3HPA) and 3hydroxypropionic acid (3HP), while methacrylic acid (MA) was produced
from 2-methyl-1,3-propanediol, a by-product of butanediol production.
Lactobacillus reuteri was employed as a whole cell biocatalyst for the
conversion of glycerol to 3HPA and 3HP in aqueous solution.
7. Potato juice, a by-product of potato starch processing, was
shown to be a promising, inexpensive nitrogen/vitamin
source for the growth of the organism and propionic acid
production
8. Propionic Acid Production by
Microbial Fermentation of Glycerol
The main production route of propionic acid is the oxo-synthesis through
hydroformylation of ethylene with carbon monoxide yielding the
intermediate propionaldehyde, which gives propionic acid on oxidation.
It is also obtained as a by-product of the chemical production of acetic acid
by liquid phase oxidation of n-butanePresents the current status for
propionic acid production from glycerol using propionibacteria in
batch/fed-batch operations.
9. oxo-synthesis
The process typically entails treatment of an alkene with high pressures
(between 10 to 100 atmospheres) of carbon monoxide and hydrogen at
temperatures between 40 and 200 C. Transition metal catalysts are
required)
10. microorganisms can produce
propionic acid
-Veillonella (parvula and
alcalescens)
-Clostridium propionicum,
-Selenomonas (ruminantium
and sputigena)
-Megashaera
-Fusobacterium necrophorum
Among them, propionibacteria
have been mostly used as hosts
for propionic acid production
Fig. 3.1 Probionibacteria
SEM of P. acidipropionici
DSM 4900 grown on glycerolbased
medium.
11. Fig. 3.2 Propionic acid fermentation pathway
The metabolic pathway for propionic acid production from different carbon sources,
showing the Wood-Werkman cycle, different intermediates and the metabolic end
products.
[1] Methylmalonyl-CoA transcarboxylase (pyruvate carboxytransphosphorylase)
[2] Malate dehydrogenase [3] Fumarase
[4] Succinate dehydrogenase [5]Propionyl-CoA:Succinate CoA transferase
[6] Methylmalonyl-CoA mutase (isomerase) [7] Methylmalonyl-CoA racemase
[8] Propionaldehyde dehydrogense (Predicted) [9] Alcohol dehydrogenase (Predicted)
12. Bio-plastics
Existing and emerging bio-based bulk plastics are starch plastics, cellulosic
polymers,
polylactid acid (PLA),
polytrimethylene terephthalate (PTT) from bio-based 1,3-propanediol (PDO),
bio-based polyamides (nylon),
polyhydroxyalkanoates (PHAs),
bio-based polyethylene (PE),
polyvinyl chloride (PVC) from bio-based PE, other bio-based thermoplastics
(polybutylene terephthalate (PBT), polyphenylene sulphide (PBS), polyethylene
terephthalate (PET), polyethylene-co-isosorbide terephthalate polymer (PEIT),
further polyesters based on PDO),
polyurethane (PUR) from bio-based polyols and bio-based thermosets.
13. Bio-solvents
Solvents are liquids that possess the ability to dissolve, dilute or extract
other substances without modifying the chemical composition of the
extracted substances or of the solvent itself.
There are eight main solvent groups:
aromatic hydrocarbons,
petroleum-based solvents,
alcohols, ketones,
esters,
ethers,
glycol ethers,
halogenated hydrocarbons
and so-called special solvents.
14.
Base on their properties, solvents are used as
degreasing agents (cleaning of metals, textiles),
additives and diluting compounds (paints, varnishes, inks, glues,
pesticides),
stripping agents (paint, varnish, glue removers)
and extraction solvents (perfumes, pharmaceuticals). Biosolvents have applications:
plant-protection oils and wetting agents and biofluxing agents.
The vast majority of bio-based solvents do not emit volatile
organic compounds (VOC) which are harmful to human health.
15. Bio-surfactants
Surfactants lower the surface tension of liquids, allowing chemicals to mix
more easily. Surfactants are usually organic compounds that are amphiphilic,
meaning they contain both hydrophobic groups (their tails) and hydrophilic
groups (their heads). Bio-surfactants are surfactants in which at least one of
the two groups (hydrophilic or hydrophobic) is obtained from plants: they
are therefore not necessarily 100% plant-derived.
16. Application of bio-surfactants
Surfactants are used in many industries such as household detergents,
personal care, industrial cleaners, food processing, oleofield chemicals,
agricultural chemicals, textiles, emulsion polymerization, paints and
coatings, lubricant and fuel additives, metal working, mining
chemicals, pulp and paper production, leather processing, etc. The
largest end use market for surfactants is household cleaning detergents.
17. Raw materials
Surfactants are made from oleochemical (bio-based) and/or petrochemical
(synthetic) raw materials. Oleochemical surfactants are commonly derived
from plant oils such as coconut and palm oils, from plant carbohydrates such
as sorbitol, sucrose and glucose or from animal fats such as tallow.
In a typical palm plantation, besides the oil and lignocellulosic biomass
sources, there is some activity to convert palm oil mill effluent (POME) to
high value chemicals and biogas.
In the case of corn wet mill and sugar cane plantations, biomass is converted
to fuel (mostly bio ethanol) and chemicals such as polyols, acids, and others.
18.
19.
20. Platform chemicals
Sugars,
Oils
and other compounds in biomass can be converted into platform chemicals
or building blocks directly or as by-products from fuel production
processes analogous to the petrochemical industry today.
23. Which Way to Go?
Various building block molecules such as 5-hydroxymethylfurfural (HMF),
derived from cellulosic biomass,
Startup companies such as Segetis: are developing novel chemicals based
on levulinic acid for use as replacement solvents and plasticizers.
Roquette :has been actively pursuing commercial scale production of
isosorbide from sugar feedstock useful in the development of
bioplasticizers and bisphenol free polycarobonate resins.
24. In the case of bio plasticizers
reFlexTM 100
thermal stability,
and improved plasticization efficiency
butyl benzyl phthalate [BBP]
diisononylcyclohexane-1, 2 dicarboxylate (DINCH)
25.
26. This is very true for bio products such as bio ethylene derived from sugar
cane or bio 1, 3 propane diol that are targeted to replace corresponding
petroleum derived products.
29. industrial
Corrosion
inhibitors,
dust control,
boiler water
treatment,
gas
purification,
emission
abatement,
specialty
lubricants,
hoses,
seals
transportation
Fuels,
Oxygenates,
Anti-freeze,
Wiper fluids
molded
plastics,
Car seats,
Belts hoses,
Bumpers,
corrosion
inhibitors
textiles
Carpets,
Fibers,fabric,
Coatings,
Foam
cushions,uphols
tery,drapes,
Lycra,
spandex
Safe food
supply
Food packing,
Presevatives,
Fertilizers,
Pesticides,
beverage
bottles,
Appliances,
Beverage can
coating,
vitamins
environment
communication
Water chemicals,
Flocculants,
Chelators,
cleaners and
detergents
Molded plastics,
Computer
casings,
Optical fiber
coating,liquid
crystal displays,
pens,
pencils,
inks,
Dyes,
Paper products
housing
Paints,
Resins,
Siding,
Insulation,
Cements,
Coatings,
Varnishes,
Flame
retardents,
Adhesives,
carpeting
recreation
Health and
hygience
Footgear,
Protectives
equipment,
Camera and
film,
Bicycle parts
& tires,
Wet suits,
Tapes-CD’sDVD’s,
Golf
equipment,
Camping
gear,boats
Plastic
eyeglasses,
Cosmetics,
Detergents,
Pharmaceuticals
,
Suntan lotion,
Medical-dental
product,
aspirin
Figure 3 – Analogous Model of aBiobasedProduct Flow-chart for BiomassFeedstocks
30. Sugar-based platform.
Platforms based on sugars (Werpy, et al., 2004) have been deployed to
create acids such as succinic acid and convert the acid to high value
chemicals such as:
2- pyrrolidone,
1, 4 butane diol,
tetra hydrofuran and others.
36. Solar cells for sustainable production of methanol from
CO2
In the BIOCOMET project,
The researchers simulate the photosynthesis process in plant cells by
manufacturing biomethanol on a large-scale, using solar cells for the
purpose.
(Bio)methanol is used as a raw material for making plastics (including
bioplastics) and also in fuels (for biodiesel and for the fuel additive MTBE).
This project is part of the BioSolar Cells programme and enables
Wageningen UR Food & Biobased Research to contribute to the Biobased
Economy.
37. Tulip compounds for production of biobased
polymers
Tulips produce tulipaline and tuliposides. These compounds play a role in
the protective mechanisms of the plant and also fight bacteria, fungi and
insects. Also, the compounds are suitable as building blocks for the
production of plastics
38. Producing hydrogen from biomass
Hydrogen is a promising fuel for the future
biomass may be used as a raw material, the conversion to electricity is
extremely efficient, and hydrogen does not contribute to the production of
CO2.
Up to the present, residual materials from the food industry, potato
steam peels, molasses, wheat bran, and barley straw have all been
studied for their potential as biomass. Eventually, cultivated biomass
such as sugar beets and sweet sorghum will also be added to this list.
39. Fermentations
About Wageningen UR
The core of biochemical hydrogen production consists of two consecutive
fermentations : During the first fermentation, when they reach 70ºC,
thermophilic (heat-loving) bacteria convert the substrate to hydrogen, CO2
and organic acids.
During the following fermentation, with the aid of light energy,
bacteria convert the organic acids to hydrogen and CO2.
This makes it possible to raise the efficiency level of the hydrogen
production as high as 75%.
Distinction is based on therenewable feedstock: 1st generation technology uses food components, such asvegetable oils, sugar and grain or animal fats, whereas 2nd generation refers tonon-food biomass, i.e. energy crops, waste biomass or agricultural residues.
Lactobacillus reuteri was employed as a whole cell biocatalyst for the conversion of glycerol to3HPA and 3HP in aqueous solution.
As well, propionic acid is integrated in cellulose acetate propionate (CAP) plastics, which are used for the manufacture of textiles, fibres, and reverse osmosis membranes.هم چنین ، پروپیونیک اسیدی که اینگره هستش در سلولز استات پروپیونات پلاستیک، که استفاده میشه برای ساخت منسوجات، فیبر ها و غشاهای ریورس اسمزیسit is also used in the production of anti-arthritic and antibiotic drug preparations, herbicides, flavours and perfumesIt can be converted to acrylates which are used in paints, resins and other products (Hasegawa et al. (1982) showed the possibility of conversion of propionic acid to 3HP, another important platform chemical, using a mutant strain of Candida rugosa)همین طور در تولید آنتی بیوتیک، ضد درد مفاصل و آماده سازی برخی دارو ها، علف کش ها، طعم ها ( اسانس ها) و عطر هاهمین طور می تونه کانورت بشه به آکریلات ( پروپنوعات ؛ نمک یا استری از پروپنوییک اسید ) که در نقاشی ، رزین ها و سایر تولیدات ( هسگاوا در سال 1982 نشان داد که احتمال تبدیل پروپیونیک اسید به 3-هیدروکسی...... با استفاده از یک گونهی موتانت شده ی کاندیدا روگوسا)
میکرو اورگانیسم هایی که توانایی تولید پروپیونیک اسید دارند:Propionibacteria are Gram-positive, non-spore پروپیون باکتری ، باکتری گرم مثبت ، بدون اسپورforming, non-motile, facultative anaerobic, حرکت ندارد،بی هوازی های گوناگونpleomorphic, rod-like microorganisms (Fig. 3.1) چند شکلی ،میله ای شکل همون طور که در شکل مشخص شده[71]. Based on their natural habitat, بر اساس زیستگاه طبیعیشون این باکتری تقسیم بندی میشه:propionibacteria are classified into: classical انواعی که از محصولات لبنی مانند شیر و پنیر جدا میشن(dairy) propionibacteria isolated from cheese andmilk and include P. freudenreichii, P. jensenii, P. مثل:پ.فرئودنریچی،پ.جنسی،پ.توئنی،پ.اسیدیپروپیونیک،پ.کوکوئیدسthoenii, P. acidipropionici, P. coccoides, P.cyclohexanicum, and cutaneous propionibacteriaisolated from human skin and include P. acnes,P. avidum and P. granulosum [71]. Besidepropionic acid, propionibacteria also produce a علاوه بر پروپیونیک اسید که پروپیونیک باکتری تولید می کند یکسری مواد صنعتی دیگه هم تولید می کنه مثل number of other industrially important productsincluding vitamin B12, trehalose, bacteriocins and exopolysaccharides [72-75] ویتامین ب12،ترهالوز،باکتریوسین و اگزو پلی ساکاریدها( پلی مری با وزن مولکولیه The whole cells of propionibacteria are even used/or can be potentially used as زیاد که از باقی مانده قند ها تشکیل میشه و توسط باکتری به محیط پیرامون ترشح starter cultures in cheese manufacture, unicellular protein for animal feed, تمامی می تونند یا پتانسیل اینکه به عنوان استاتر در پنیر استفاده کنند، مواد افزودنی leavening additive for baking, and in preparation of ensilage [71]. برای نان و و و و .....
The type and the degree of reduction (γ) of the carbon source influences the انواع درجه ی عدد کاهش برای منبع کربن تاثیر میذاره الگو های متابولیکی به دست امدpattern of metabolic by-products obtained [76]. With the majority of carbon با اکثریت منبع کربن شامل گلوکز ، لاکتوز ، زایلوز، سوکروزو لاکتات، استیک اسید به sources including glucose, lactose, xylose, sucrose and lactate, acetic acid is عنوان مادهی جانبی اصلی تولید شده به حساب میاد در حالیکه گلیسرول درست مقابل obtained as a major by-product (Eq8, 9)1. Glycerol, in contrast, این هستش که منجر به به یک الگوی همو پروپیونات فرمنتیشن میشه با بازده بالاtriggers ahomopropionate fermentation pattern leading to a high propionate yield (Eq10)[52, 77-79]. Since glycerol is more reduced than other carbon sources, its گلیسرول نسبت به سایر منابع کربن بیشتر کاهش می یابد ،conversion to pyruvate generates higher amount of reducing equivalents, drivingthe metabolic flux towards propionic acid to achieve the required co-factor balance.Glucose, on the other hand, generates lower amount of reducing equivalents, and در حالیکه گلوکز کمترین میزان کاهش رو داره و علاوه بر این تولید استاتhence acetate production is preferred as a source for ATP, yielding higher cell ترجیح داده میشه به عنوان منبع برای انرژِی، ابزدهی و دنسیت تولیدdensity. Consequently, the molar ratio of propionic acid to acetic acid (PA/AA) is در نتیجه ، نسبت پروپیونیک اسید به استیک اسید به طور زیادی تحت اثر منبع کربن greatly affected by the carbon source and could vary between 2:1 when lactate is هستش و می تونه متفاوت باشه بین 2و 1در حالیکه لاکتات استفاده میشه utilized to 30:1 in case of glycerol [77]. 30:1 در مورد گلیسرول. Most propionibacteria can cover their own needs of vitamins, except for biotin اکثر پروپیون باکتری ها می تونند نیاز های خودشون رو بر طرف کنن ( ویتامین جز برای (vitamin B7) and pantothenic acid (vitamin B5) that should be supplementeبیوتین ب7 و پنتوتنیک اسید ب5 که باید
Raw materialsThe starting raw materials are usually sugars or starches, partially also recycled materials from foodor wood processing. Algae based resin production has also been announced to be commercialised bythe end of 2010.
Raw materialsBiosolvents can be entirely or partially plant-based. Examples of bio-solvents are soy methyl ester(soy oil esterified with methanol), lactate esters (fermentation derived lactic acid reacted withmethanol or ethanol) and D-Limonene (extracted from citrus rinds).
Whole crop biorefineryIn a whole crop biorefinery, grain and straw fractions are processed into a portfolio of end products. Abengoa Bioenergy is commissioning the first commercial-scale whole crop biorefiner plant in Spain, daily processing 70 tons of agricultural residues (wheat, barley straw) to produce annually over fivemillion litres of fuel grade ethanol.Marine biorefineryThe global primary biomass production is equally divided between terrestrial and aquatic systems. So far, policies have focused mainly on terrestrial biomass, little attention being devoted to marine sources like microalgae and macroalgae and their derivatives. Algae can, depending on species and growingconditions, accumulate significant amounts of oils, carbohydrates, starch and vitamins. (Source: Langeveld et al.19)
The twelve sugar-based building blocks are: 1,4-succinic, fumaric and malic acids, 2,5- furan dicarboxylic acid, 3-hydroxy propionic acid, aspartic acid, glucaric acid, glutamic acid, itaconic acid, levulinic acid, 3-hydroxybutyrolactone, glycerol, sorbitol and xylitol/arabinitol. The list was derived by examining the potential markets for the building blocks and their derivatives and the technical complexity of the synthesis pathways. Utrecht University et al 13 report and the FROPTOP program identified a larger list of viable bulk organic chemicals from biomass by application of ‘white biotechnology’, i.e. industrial biocatalysis.
From ligninAnother product from biomass based processes is lignin18. At the moment it is mainly used to produce process heat by combustion or in animal feeds although around 1 million tonnes of lignin polymers are traded as chemicals. However, lignin also has the potential to be a chemical feedstock 18. Lignin can be used as a carbon source by gasification producing syngas (carbon monoxide/ hydrogen), which can be transformed into methanol, dimethyl ether, olefins and mixed alcohols (ethanol and higher value alcohol chemicals). In addition lignin can be converted into aromatic hydrocarbon products that can be used commercially (e.g. phenol or vanillin)27. The single most important group of plastic precursors, for which bio-based alternatives are still missing, are aromaticcompounds. Lignin could be an answer to this need even though it is structurally very complex and diverse, making the production of aromatic compounds from biomass a major challenge.
PBT (Polybutylene terephthalate) and PET (Polyethylene terephthalate)
(researchers from Wageningen UR Food & Biobased Research and Plant Research International, part of Wageningen UR, together with biomethanol producer BioMCN from Delfzijl, are all working on the development of a sustainable production of methanol from CO2.)