1. Prospect of
CSC-targeting Therapy
Kyoto Univ.
Faculty of Medicine (1)
Seigi Oshima

2. Outline
1. Cancer stem cells (CSCs)
2. Previous studies on CSC-targeting
therapy
3. My suggestion on the novel therapy
4. Conclusion

3. What’s a Cancer Stem Cell (CSC)?
CSC….
This figure is cited from http://www.childrenshospital.org/gallery/index.cfm?G=67

4. Normal anticancer drugs target
only nCSCs….
nCSC
CSC
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5. CSC-targeting Therapy
1. Differentiation therapy
2.CSC niche targeting therapy
3. Direct reprogramming

6. What’s direct
reprogramming?

7. What’s Direct Reprogramming?
differentiation
iPS cells Cells you like
Somatic cells
Cells you like

8. Previous Studies
Yamanaka factors
Cancer cells iPS cells

10. Suggestion
• If direct reprogramming can be
applied to CSCs, then this method is
novel cancer treatment.
certain transcription factors
Cancer Stem Cells Normal cells

11. Hurdles toward my suggestion
1. Possibility of developing cancer
2. Extraction of pure CSCs from
tumors
3. Drug delivery system

12. The Future Prospect
• CSC Drug Discovery of Victory over
CSC-targeting
markers Screening drug cancer