Ultra-Sensitive Microsensors for Chemical Analysis, pumpsandpipesmdhc

Alan Schilowitz , Andy Riley, Dalia Yablon, Mark Disko ExxonMobil Research and Engineering Co. Corporate Strategic Research Laboratory Annandale, New Jersey Ultra-Sensitive Microsensors for Chemical Analysis

Why Microsensors ? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

How Many Cantilevers Can Fit on the Head of a Pin ? 2 mm ,[object Object],[object Object],[object Object]

Micro-Cantilevers Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Laser PSD Focusing Lens

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Analysis in Dynamic Mode 0 2000 4000 6000 8000 10000 12000 Frequency (Hz) Amplitude Air Increasing Viscosity

Cantilevers Respond to Viscous Damping High Q Low Q Increasing Viscosity ,[object Object],[object Object],[object Object]

Chemical Analysis in Static Mode ,[object Object],Selective adsorbant on one side only Untreated Cantilever Gold Coated Cantilever Detects Mercaptans Mercaptan Injection ,[object Object],[object Object]

Functionalized Cantilever Arrays for Aromatics Detection Self-Assembled Monolayers Impart Chemical Selectivity to Highly Sensitive Cantilever Transducers Self-Assembled Monolayer Candidates: SH Benzyl Mercaptan SH Naphthalenethiol SH OH Mercaptohexanol SH ( ) 6 Octadecanethiol

Cantilever Response To Aromatic Vapor ,[object Object],[object Object],S OH S S ( ) 6 S toluene xylene toluene xylene d. ODT - octadecanethiol c. MH - mercaptohexanol b. NT - naphthalenethiol a. BM – benzyl mercaptan toluene xylene toluene xylene

Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Medical Applications Light traces are before exposure to e-coli Dark traces are after exposure B. Illic et.al., Appl. Phys. Lett. 77 (3), 450 (2000) E-Coli Sensor ,[object Object],[object Object],W. Guanghua et.al., Nature Biotechnology 19 , 856 (2001) Prostate Specific Antigen (PSA) Sensor

References - Medical Applications Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA Zhang, J.; Lang, HP.; Huber, F.; Bietsch, A.; Grange, W.; Certa, U.; McKendry, R . ; Guntherodt, HJ.; Hegner, M. & Gerber, Ch. Nature Nanotechnology , 1 , 214-220 (2006). Novel electrical detection of label-free disease marker proteins using piezoresistive self-sensing micro-cantilevers Wee KW, Kang GY, Park J, Kang JY, Yoon DS, Park JH, Kim TS Biosens Bioelectron 2005 Apr 15;20(10):1932-8 Array of NanoCantilevers as a BioAssay for Cancer Diagnosis Klein, K.M.; Jiantao Zheng; Gewirtz, A.; Sarma, D.S.; Rajalakshmi, S.; Sitaraman, K. Electronic Components and Technology Conference, 2005. Proceedings. 55th Volume , Issue , 31 May-3 June 2005 Page(s): 583 - 587 A Review of Microcantilevers for Sensing Applications Vashist, S.K., June 2007 www.azonano.com/details.asp?ArticleID=1927

Ultra-Sensitive Microsensors for Chemical Analysis, pumpsandpipesmdhc

Recomendados

Recomendados

Más contenido relacionado

La actualidad más candente

La actualidad más candente (20)

Destacado

Destacado (7)

Similar a Ultra-Sensitive Microsensors for Chemical Analysis, pumpsandpipesmdhc

Similar a Ultra-Sensitive Microsensors for Chemical Analysis, pumpsandpipesmdhc (20)

Más de tmhsweb

Más de tmhsweb (20)

Último

Último (20)

Ultra-Sensitive Microsensors for Chemical Analysis, pumpsandpipesmdhc