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Cisplatin
- 1. CISPLATIN Terry Clayton Biological Inorganic Chemistry April 1, 2007
- 6. Cisplatin Synthesis Dhara, S.C., A Rapid Method for the Synthesis of cis-[Pt(NH3)2Cl2], Indian Journal of Chemistry, vol. 8, No. 2, Feb. 1970, pp. 193-194.
- 7. F. Coste, J. M. Malinge, L. Serre, W. Shepard, M. Roth, M. Leng and C. Zelwer, "Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 A resolution: hydration at the platinated site", Nucleic Acids Res , 1999, 27 , 1837
- 14. Cytotoxicity Cisplatin-Resistant Tumor Lines IC 50 ( µM) Cancer cell line cisplatin 1 Chronic myelogenous leukemia K562 >80 3 Chronic myelogenous leukemia KG-1 48 2 Acute myelogenous leukemia ML-2 >80 1 Mouse melanoma B16 >80 6 Colon cancer HT-29N >80 12 Colon cancer HT29 50 8 Colon cancer HCT116 >80 9 Lung carcinoma A427 63 6 Breast carcinoma HBL100 63 6 Breast carcinoma MCF-7 71 8 Lung carcinoma CORL23/CTR >80 25 Ovarian carcinoma A2780 4 4 Ovarian carcinoma A2780/cis 40 3 Ovarian carcinoma A2780/cis90 >80 7
- 15. Questions
- 16. Thank You
Notas del editor
- While studying electric fields and growth of E. Coli/// Rosenberg 1964 Group VIIIb transition metal compounds inhibit cell division 1-10ppm Growth not affected Components of the experimental medium were electrolyzed and tested for the presence of oxidizing agents by reacting with KI/starch solutions. Positive results were found for NH4Cl. NH4)2PtCl6 was formed to be the active agent.
- the trans effect is the labilization of ligands trans to certain other ligands, which can thus be regarded as trans directing ligands.
- F. Coste, J. M. Malinge, L. Serre, W. Shepard, M. Roth, M. Leng and C. Zelwer, "Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 A resolution: hydration at the platinated site", Nucleic Acids Res , 1999, 27 , 1837
- Preformed Pt- HSA (human serum albumin) administered clinically to patients there was increased survival time. Individuals with low HSA did not respond well to cisplatin Centerwall at Syracuse found using HSQC NMR N15 NMR-h1
- Carboplatin cyclobutane dicarboxylate decreases reactivity. Oxaliplatin for colon cancer…oxalate increases water solubility…othermechanisms unknown
- Many insecticides show cross resistance Increased reactivity with glutathione may reduce cytotoxicity
- Lead compound in future studies of Pt. compounds with hydrophobic ligands. They speculate that the structure of water molecules around adamantineamine affect reaction with glutathione and thiols.