ayurvedic drugs useful in musculoskeletal pain which is very effective .

1. GUIDE:-
Dr. Ashwini Kumar Sharma Dr.Rajesh Chand Mishra
M.D.(Ayu),PhD. M.D.(Ayu.)
A CRITICAL ANALYSIS OF AYURVEDIC
HERBAL DRUGS AND MINERALS IN
THE MANAGEMENT OF
MUSCULOSKELETAL PAIN
SCHOLAR:-
DR. DEEPAK VERMA
M.D. (Ayu.) 2nd year

2. Introduction :
The humаn muѕсulоѕkеlеtаl system is wіdеlу
known as thе lосоmоtоr system. This іѕ an
оrgаn ѕуѕtеm thаt еnаblеѕ humаnѕ thе ability tо
move bу thе use оf thе ѕkеlеtаl and muscular
system.
Musculoskeletal pain is pain that affects the
muscles, ligaments and tendons, and bones.

3. What Causes Musculoskeletal
Pain?
The causes of musculoskeletal pain are varied. Muscle
tissue can be damaged with the wear and tear of daily
activities. Trauma to an area (jerking movements, auto
accidents, falls, fractures, sprains, dislocations, and
direct blows to the muscle) also can cause
musculoskeletal pain. Other causes of pain include
postural strain, repetitive movements, overuse, and
prolonged immobilization. Changes in posture or poor
body mechanics may bring about spinal alignment
problems and muscle shortening, therefore causing
other muscles to be misused and become painful.

4. What Are the Symptoms of
Musculoskeletal Pain?
People with musculoskeletal pain sometimes
complain that their entire bodies ache. Their
muscles may feel like they have been pulled or
overworked. Sometimes, the muscles twitch or
burn. Symptoms vary from person to person,
but the common symptoms are:
Pain
Fatigue
Sleep disturbances

5. Tуреѕ Оf Muѕсulоѕkеlеtаl
Pаіn
Arthrіtіѕ іѕ broadly саtеgоrіzеd аѕ аn
іnflаmmаtіоn of the jоіntѕ thаt саuѕеѕ pain,
еѕресіаllу іn thе extremities (ѕuсh аѕ thе fingers
аnd hаndѕ). Muѕсlе раіn rаngеѕ frоm аn
аnnоуіng асhе tо severe (almost раrаlуzіng)
stiffness. The injury іѕ a соmmоn саuѕе оf
muscle раіn, but аn infection, lасk оf blооd flоw,
оr a tumor саn аlѕо bе thе cause оf thіѕ type оf
раіn.

6. Con :
Pаіn аѕѕосіаtеd wіth Fіbrоmуаlgіа іѕ оftеn tіmеѕ
lоng-lаѕtіng аnd dіffісult fоr раtіеntѕ to dеѕсrіbе, as
the раіn can bе іn ѕеvеrаl areas оf thе bоdу. Othеr
symptoms аѕѕосіаtеd wіth thіѕ condition may
іnсludе fatigue and depression.
Back pain is a соmmоn аіlmеnt оf аdultѕ and is
usually аѕѕосіаtеd wіth аn оссuраtіоn оr a lifestyle.
Thе аrеаѕ affected аrе thе neck to thе lоwеr bасk.
Back раіn саn bе caused by ѕоrе muѕсlеѕ, herniated
dіѕсѕ, or nerve dаmаgе.
Rереtіtіvе strain іnjurу оссurѕ іn іndіvіduаlѕ who
реrfоrm a рhуѕісаl tаѕk repeatedly. Wrіtеr’ѕ cramp
and carpal tunnеl ѕуndrоmе аrе excellent еxаmрlеѕ
оf thіѕ painful соndіtіоn.

7. Pain Management :
Musculoskeletal Pain
1.Anti-inflammatory
Herbs
2.Pain Relieving Or
Analgesics Herbs
3.Anti-oedematous
Herbs
4.Immunomodulator
drugs

8. Desmodium gangeticum शालपर्णी
shalaparni
Gangetin, one of the
Pterocarpans, isolated from the
hexane extract of the root of the
plant Desmodium gangeticum..
The compound showed
significant anti-inflammatory
activity in the exudative and the
proliferative phases of
inflammation in the doses of 50
and 100 mg/kg orally. The
compound showed significant
analgesic activity. It did not show
any anti-fertility and antipyretic
activity in albino rats. It did not
show acute toxicity in mice upto
an oral dose of 7 g/kg.

9. Withania Somnifera
The main chemical constituents
are alkaloids and steroidal lactones.
These include tropine and cuscohygrine.
The leaves contain the steroidal
lactones, withanolides, notably withaferin
A, which was the first to be isolated from
the plant.
Withaferin A is a steroidal lactone. his natural
product has wide range of pharmacological activities
including cardioprotective, anti-inflammatory,
immuno-modulatory, anti-angiogenesis, anti-
metastasis and anti-carcinogenic properties.
Withania roots have demonstrated
chondroprotective effects in
vitro arthritis model.

10. BOSWELLIA SERRATA/RHOMBIFOLIA EXTRACT
Boswellia Serrata, commonly called
Shallaki is a plant is known for anti-
inflammatory and anti-cancer properties
of Boswellic Acids derived from it.
It is also a fragrant resin with wide use
in incense and perfume manufacture.
This resin has many pharmacological
uses.
The oleo-gum resin of Boswellia Serrata
is a complex mixture of lower and
higher Terpenoids and carbohydrates.
Higher Terpenoids, collectively called
the Boswellic Acids are the major
fraction of the resin (25-35%).
Boswellic Acid 65%-85%
extract

11. Sidacordifolia rootextract
Sida cordifolia extracts of the aerial
and root parts showed good
analgesic, antiinflammatory and
hypoglycaemic activities. The ethyl
acetate (EA) extract of root (SCR-E)
showed comparable
antiinflammatory activity with
indomethacin and possessed
significantly higher activity when
compared with that of the methanol
extract of the root part (SCR-M). The
ethyl acetate extract of both root
and aerial parts of Sida cordifolia
(SCR-E and SCA-E) showed very good
central and peripheral analgesic
activities at a dose of 600 mg/kg.

12. Ginger (Zingiber officinale)
Gingerol, shogaol, and other
structurally-related substances in
ginger inhibit prostaglandin and
leukotriene biosynthesis through
suppression of 5-lipoxygenase or
prostaglandin synthetase.
Additionally, they can also inhibit
synthesis of pro-inflammatory
cytokines .
If consumed in reasonable
quantities, ginger has few
negative side effects. It is on
the FDA's "generally recognized as
safe" list, though it does interact with
some medications, including
the anticoagulant drug warfarin[16] an
d the cardiovascular drug, nifedipine.

13. Strychnos nuxvomica
Alkaloids, Indole Alkaloids, Strychnine &
Brucine, Monoterpenoid Glycoside
(Loganin), α, β -Colubrine, Vomicine.
It is used for nerve
conditions, depression, migraine
headache, symptoms of menopause, and
a blood vessel disorder called Raynaud's
disease.
The detoxified seeds of Kuchla are used in
treatment of neuralgia, facial palsy,
hemiplegia, arthritis, gout, muscle pain,
nerve pain etc. in low recommended
dosage only. The seeds are nervine tonic
and digestive.
Nux-vomica gives relief in excessive vata
and pain. It strengthens and stimulates
nerves. It is a good appetizer, digestive and
cures indigestion.

14. Hyoscymus niger (Khurasani
Ajwain)
Hyoscyamine, hyoscine, isomeric N-oxides of
hyoscyamine (equatorial and axial),
hyoscine-N-oxide (equatorial isomer),
cannabisin G, grossamide,
hyoscyamide;rutin;daucosterol, ßsitosterol,
myristic, palmitic, stearic, oleic and linoleic
acids.
It is also used as substitute of opium
because of its hypnotic, hallucinogenic,
narcotic, and sedative properties. Every part
of Khurasani ajwain plant contains
alkaloids. medicine system the seeds of
Khurasani ajwain are first detoxified and
then used. For this purpose, the seeds are
soaked in vinegar for three consecutive night
and then dried and powdered. This powder
is used for medicinal purpose.

15. Calcium sources
Shankha and praval has abillity to easily absorb
and compensate the calcium required by the
body.theses are natural source of calcium and vit c
which is good for the development and
maintenance of healthy bones,teeth and cell
memberanes.
How Much Do You Need?
Children 1-3 years old: 700 milligrams (mg)
Children 4-8 years old: 1,000 mg
Children 9-18 years old: 1,300 mg
Adults 19-50: 1,000 mg
Women 51 to 70: 1,200 mg
Men 51 to 70: 1,000 mg
Women and men 71 and over: 1,200 mg
Calcium metabolism, which is very essential for
the rigidity of bones is regulated by the intestines
by adjusting the absorption of calcium.

16. shilajeet
According to the legends famous in India shilajit is
considered as nectar or amrit of God given to mankind
to live life youthfully and become immortal forever. . It is
pale brown to blackish brown in colour. This resin is soft
in texture, slimy to touch, pure and heavy. It is soluble in
water. Others names by which shilajit is famous are
asphaltum, mineral pitch, and girij.
Shilajitu is considered has ushanvirya i.e. it possess hot
potency, which makes it, fight against the ailments caused
by vata disorder. It possesses katu, tickt and kashaya rasa
and possesses laghu (light) and ruksh (dry) properties,
which helps it in acting the way it works. Due to presence
of these properties shilajit acts as vata and kapha
suppressant, it also helps in moderating pitta dosha.
Shilajit is said to contain many biochemical's, mainly fulvic
acid but humic acid, uronic acids, hippuric acid,
benzopyrones, phenolic glycosides and amino acid are
also present. Shilajit should never be taken in raw form,
first it is purified and then used.

17. There are lots of costly market drugs or
aushadh yogs which can reduce or manage the
musculoskeletal pain,but we need to be
prescribe or use single drug therapy. They can
be use long time without any harmful or
adverse effects and help to maintain the pain. I
describe here drugs like
shalparni.shallaki,bala,praval and shnkha
churna and shilajatu also,

18. REF. GOOGLE SEARCG, TEXT BOOKS AND INTRNET