38. “ The only gracious way to accept an insult is to ignore it. If you can’t ignore it, top it. If you can’t top it, laugh at it. If you can’t laugh at it, it’s probably deserved ...! ” –Joseph Russell Lynes
50. Prostate Cancer – Gleason grade 3 Gleason grade 3: Pleomorphic glands. There is considerable variation in size, shape, and spacing of the glands. The glands are haphazardly infiltrating the stroma; however, they are still discrete (i.e. there is no fusion of glands - a hallmark of Gleason grade 4). Some of the glands have occluded or abortive lumens.
54. Most prostatic tumours include components of two or more patterns and therefore current practice gives the grade of the two most common components and their sum. This is known as the combined Gleason grade or score. For example, in this image many glands in this example are fused (Gleason grade 4); others maintain individual outlines but are closely packed with their neighbours (Gleason grade 3). Therefore, the score is 7 (4+3). Prostate Cancer High grade
89. Today is the First Day, of Rest of Your Life...!
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91. Referral - if >5 mm or has not passed after two weeks. US X-Ray no contrast Helical CT Management
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94. Prostatic neoplasms: Overview Rare Normal Microscopic focus of adenocarcinoma Any site Commoner than clinical carcinoma; 80% of glands over 75 years Latent (incidental) carcinoma Bone Lymph node Lung Liver Raised in approximately 60% of cases Infiltrating adenocarcinoma Posterior subcapsular zone Common tumour; peak 60-85 years Clinical (symptomatic) carcinoma None Normal Nodular hyperplasia of glands and stroma Peri-urethral zone 75% of men >70 years Benign nodular hyperplasia Metastases Serum acid phosphatase Morphology Location in gland Incidence Condition