Status of Korea Bio industry and KoreaBIO.

1. Status of Korea BIO Industry
15Th April 2016
Jaehyuck Jerry Yang
Head of Business Development
Korea Biotechnology Industry Organization

2. Korea Bio Industry 2
Status of Korea BIO Industry

3. Korea Bio Industry 3
Status of Korean Biotech Value Chain
Source
technology
Science
Technology
Product
Univ, Institute
BIO-venture
Pharmaceutical company
Patents Regulation
- Korea, Science sector 12th, Patent sector 4th
-1st generation of Korean Biotech company have more than 15 years
- Entrance of conglomerate company and pharmaceutical company
- Supported by IT Infra and clinical capacity
Benefit
“Clinician”
ICT
Development
conglomerate
Source: KB Investment

4. Korea Bio Industry 4
Technology gap

5. Korea Bio Industry 5
Bio-Clusters supporting R&D Growth
Source: Invest Korea – Medical/Bio Promising Investment Opportunities (2012), Quintiles Internal Analysis.
Synergistic relationship between Bio-Clusters, Regional Clinic
al Trial Centers (Hospitals) & Pre-Clinical Facilities

6. Korea Bio Industry 6
Clinical Trials Country Ranking
Source: Invest Korea – Medical/Bio Promising Investment Opportunities (2012), Quintiles Internal Analysis.

7. Korea Bio Industry 7
Clinical Trials City Ranking
Source: Invest Korea – Medical/Bio Promising Investment Opportunities (2012), Quintiles Internal Analysis.

8. Korea Bio Industry 8
Clinical Trials in Korea
Source: Invest Korea – Medical/Bio Promising Investment Opportunities (2012), Quintiles Internal Analysis.

9. Korea Bio Industry 9
Venture Capital Investment
ETC
Distribution/Service
Game
Movie/Music/Event
BIO/Medical
Chemical/Metrials
Elect/Machine/Device
ICT Service
ICT Manufacturing
• 2015 Bio/Medical Investment : 284 M US$
• 2015 Bio/Medical Investment Ratio : 15.2%
• Early 2000 Bio/Medical Investment Ratio : 2%

10. Korea Bio Industry 10
Korea Drug Development Fund (KDDF)

11. Korea Bio Industry 11
Recent Highlights in Korea
Giant Going into Medical device
Samsung investment 2 billion in medical device (acquired Medison)
SK investment in Nanoentech
Biological drugs
2 billion investment in biosimilar (Samsung Biologics with Qunitiles)
Celltrion getting 200 million investment from Temasek
LG investing in biosimilars
Regenerative medicine
Smart Healthcare
Stem-cell research, later state clinical development
Feasibility study undergoing with 10,000 diabetic patients

12. Korea Bio Industry 12
Bio-tech Company Activities
Global
pharmaceuticals
Bio-tech company
Laboratory
Unmet needs
License out
or
M&A
Source: KDB Daewoo Security
Value Chain Type Korean Golobal
M&A SD Inverness
Medical
Innovations(USA)
Cooperat
ion
Binex Nichi-Iko
Pharmaceutical
(Japan)
Joint
Venture
Donga Pharm. Meiji Seika
Pharma
(Japan)
Genexine Ajinomoto
(Japan)
Yuhan Corp. Sorrento
Therapeutics
(USA)
Tech.
Transfer
Meditox Allergan(USA)

13. Korea Bio Industry 13
Joint Venture
Yuhan(51%) +
Sorrento(49%)
Immune checkpoint
Monoclonal Antibodies
Northlad(51%)+Huons(45%)
+Interlim(4%)
eye bath drops

14. Korea Bio Industry 14
Joint Venture
Ajinomoto Genexine Co., Ltd.
Ajimoto(75%) + Genexine(25%)
Medium Business
인천 송도 공장 준공(2014)
Biosimilar(Korea, Japan Market)

15. Korea Bio Industry 15
Technology Transfer
• Hanmi Pharm-Sanofi(Diabetes)
• Hanmi Pharm-BI (EGFR)
• Hanmi Pharm-Zai Lab (EGFR)
• CJ-Luoxine Biotech (PCAB in GERD)
• Kainosmedicine-YANGZHOU AIDEA BIOTECH(2Anti-cancer
drug)
• Legochembio-Fosun Pharma (ADC antibody)
• Sorrento-Lee's Pharma (PD-L1 antibody)
• Genexine-Talsy (3 protein therapies)

16. Korea Bio Industry 16
About KoreaBIO

17. Korea Bio Industry 17
KoreaBIO - History
1982. Korea Biotechnology Research Association(KBRA) founded
1991.11 Bio-industry Association of Korea(BAK) founded
2000. 7 Korea Bio-venture Association(KOBIOVEN) founded
2008.11 BAK, KOBIOVEN and KBRA merged into Korea BIO

18. Korea Bio Industry 18
• Pangyo Techno Valley – Korean Silicon Valley
• Korea Bio Park consist of 3 buildings with 22 Companies.
• Communication and Sustainability
+30 companies
+1,000 People
+ 2 Association
KoreaBIO - Korea Bio Park(since 2005)

19. Korea Bio Industry 19
KoreaBIO - Member Company
Most of the top pharmaceutical
companies
Most of 35 bio-technology
companies listed on the Kosdaq
They have worked in
Bio-technology,
Pharmaceutical,
Medical device etc
Total + 300 member companies
<Top 10 Pharm Companies in Korea>
Rank Company Name Sales(M$)
1 Hanmi Pharm 11.46
2 Yuhan Corporation 9.81
3 Green Cross 9.11
4 Kwangdong 8.31
5 Daewoong Pharma 7.30
6 Celltrion 5.25
7 Jeil Pharm 5.17
8 Chong Kun Dang 5.15
9 Donga ST 5.05
10 Ildong Pharma 4.14

20. Korea Bio Industry 20
Korea Bio Activity
R&D
Education
Business
/Investment
Policy
/Regulation
Member
Service
+300 Members
+28 Staffs

21. Korea Bio Industry 21
Cooperation with China
• 2013.6 MOU with BPBC(Beijing Pharma and Biotech Center)
• 2015.4 MOU with Zhongguancun Changping Science Park
• 2015.9 Korea-China Bio Forum & Partnering
• 2013.10-2015.10 Health Industry Forum in Beijing(3times)
• 2016.5 Korea-China Bio Forum & Partnering

22. Korea Bio Industry 22
Innovation Initiatives
Cure Diagnosis Care & Prevention
Molecular Diagnosis
Medical Devices
Pharmaceuticals Company
DNA sequencing
Medical service effectiveness improvement
opportunity cost reduction
Healthcae Service Trends
KoreaBIO’s Innovative cooperation with new Committees
Korea IVD Committee
•Since 2011
•75 companies
Korean Genome Company
Committee
•Since 2015
•16 companies
Smart Healthcare
Committee
•Since 2015
•Kick off meeting on Oct 13th

23. Korea Bio Industry 23
Jaehyuck Jerry Yang
KoreaBIO
Cool@koreabio.org
+82-31-628-0021