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M.V. LOMONOSOV  MOSCOW  STATE UNIVERSITY FACULTY  OF  BASIC  MEDICINE Complex  Combination Biochemotherapy  In  Advanced Metastatic Melanoma  Dr. Aung Citt Nyein (M.B.,B.S) Scientific Supervisor: Prof. Dr. Lev Demidov N.N. BLOKHIN CANCER RESEARCH CENTRE MOSCOW, 2010 N.N. BLOKHIN CANCER RESEARCH CENTRE
INTRODUCTION ,[object Object],[object Object],[object Object]
[object Object],[object Object]
AIM  OF  STUDY  ,[object Object],[object Object],[object Object],[object Object]
RESEARCH  OBJECTIVES ,[object Object],[object Object],[object Object]
RISK FACTORS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CHARACTERISTICS OF MELANOMA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Superficial Spreading Melanoma
Large Nodular Melanoma
TREATMENT  REGIMENS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Material and Methods ,[object Object],[object Object],Regimen Treatment Schedule DTIC 850 mg / m² iv , day 1 Vindesine 1.6 mg / m²  iv , days 1-5 Cisplatin 20 mg / m²  iv , days 2-5 Interleukin-2 9 MU / m²  iv , days 1-5 Interferon- α 2b 5 MU  IE sc , days 1-5
Patients Characteristics (No. of organ affected)
Patients Characteristics (Previous Therapy)
Tumour response to therapy CR -complete remission  : PR -partial remission : SD -stable disease :  PD -disease progression
Toxicities of Chemo and Immunotherapeutic Agents Toxic Effects
Dosage reduction for each of the chemo and Immunotherapeutics Agents Reduction Rate
CONCLUSION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
 

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