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- 1. M.V. LOMONOSOV MOSCOW STATE UNIVERSITY FACULTY OF BASIC MEDICINE COMPARISON OF POLY- CHEMOTHERAPY (CVD regimen) & THE SAME CHEMOTHERAPY (CT) PLUS INTERFERON-α2a IN METASTATIC MELANOMA Student: Dr. Kyaw Thura Zaw Scientific Supervisor : Prof. Dr. Lev Demidov N.N. BLOKHIN CANCER RESEARCH CENTRE Moscow ,2010
- 5. Race Melanoma is more common in whites than in blacks and Asians. The rate of melanoma in blacks is estimated to be 1/120 that of whites. Sex Melanoma is slightly more common in men than women (1.2:1). Melanoma is the 5th most common malignancy in men and the 6th most common malignancy in women, accounting for 5% and 4% of all new cancer case. respectively.
- 7. A=Asymmetry B=Border (irregular) C= Color D= Diameter ABCD Properties of Radial Melanomas
- 8. A 1.5-cm melanoma with characteristic asymmetry, irregular borders, and color variation.
- 10. AIM OF STUDY To Study and Compare the Poly-chemotherapy (CVD regimen) & the Same Chemotherapy(CT)plus Interferon α - 2 a in Metastatic Melanoma.
- 13. Patient’s Characteristics CVD P CVD+IFN P Age , median (min-max) 55 (35-65) P<0.01 52(30-65) P<0.10 ECOG PS 0 2 P=1.00 2 P=1.00 1 3 P>0.10 6 P>0.25 2 10 P>0.10 7 P>0.30 Metastatic sites Skin 4 P>0.25 6 P>0.10 Lymph node 10 P>0.70 9 P>0.25 Lungs 9 P=1.00 9 P=1.00 Liver 9 P>0.10 6 P>0.10 Other 3 P>0.10 0 P>0.20 Number of Metastases 1 1 P>0.10 4 P>0.10 2 8 P>0.70 7 P>0.70 3 6 P>0.25 4 P>0.25
- 17. Overall survival. Heavy line represents CVD + IFN group; Fine line represents CVD group ; No. of death /Total No. Average survival Survival Median CVD+IFN 8/15 13.51(9.7;17.3) 12.0(9.9;14.1) CVD 7/15 10.75(9.1;12.4) 12.0(7.8;16.2)