4. INTRODUCTION
cancer
Caused by
Mutations will cause
chromatin
division
organization
Can cause Caused by
mutations on the exposition to risk
genome factors

5. MUTATION RATES IN CANCER CELLS STRONGLY
LINKED TO HOW CHROMATIN IS ORGANIZED
Cause
Cancer is
mutations
a genetic
on the
desease
genome
Chromatin
In cancer
organization
cells
linked
Rare
chromatin,
higher
mutation

6. MUTATION RATES IN CANCER CELLS STRONGLY
LINKED TO HOW CHROMATIN IS ORGANIZED
Many types of
tissues were studies
And many types of
cancer
Prostate and lung
melanoma leukemia
cancer

7. MUTATION RATES IN CANCER CELLS STRONGLY
LINKED TO HOW CHROMATIN IS ORGANIZED
THIS KIND OF STUIDES ARE
ECONOMIC, BECAUSE THE INFORMATION IS
THE INFORMATION WAS AVILABLE AND FREE FOR
ALREADY TAKEN EVERYBODY
THE INFORMATION
ALLOWS TO KNOWM
MORE ABOUT
GENETICS DISEASES
AS CANCER

8. MUTATION RATES IN CANCER CELLS STRONGLY
LINKED TO HOW CHROMATIN IS ORGANIZED
Establish a
objective
relationship beetwen
how chromatin is
organized and Cancer
rates

9. MUTATION RATES IN CANCER CELLS STRONGLY
LINKED TO HOW CHROMATIN IS ORGANIZED
ANY STUDY ABOUT CANCER AND
ITS CAUSES CAN BE RELEVAN IN
THE PROCES TO FIND A CURE,
KNOWING ITS CAUSES, ORIGINS
AND SOME MARKERS IS ESSENTIAL
TO IMPROVE TREATMENTS AND
MEDICINES
PERSONAL COMMENT

10. DNA DAMAGE IN ROOFERS DUE TO PAH
EXPOSURE, POSSIBLE CANCER LINK
PH Polycyclic aromatic
hydrocarbons are potent
A atmospheric pollutant As a
pollutant, they are of concern
because some compounds
have been identified
as carcinogenic, mutagenic,
and teratogenic

11. DNA DAMAGE IN ROOFERS DUE TO PAH
EXPOSURE, POSSIBLE CANCER LINK
ROOFERS AND ROADWORKERS ARE
CONSTANTLY EXPOSED TO PHA, BUT
ALSO ARE EXPOSED TO SMOKE, UV
LIGHT, AND MORE CARCINOGENIC
AGENTS THAT CAN INCREASE
CANCER RATES IN THIS POPULATION
ALL OF THEM, CAUSE
DAMAGE IN THE DNA

12. DNA DAMAGE IN ROOFERS DUE TO PAH
EXPOSURE, POSSIBLE CANCER LINK
THE SAMPLES WERE TAKEN acute exposure to
UNDER SOME STANDARDS hot asphalt
AS:
workers who reported workers who didn't use
work related skin protective gloves
burns

13. DNA DAMAGE IN ROOFERS DUE TO PAH
EXPOSURE, POSSIBLE CANCER LINK
PHAS ARE PRODUCED
by incomplete
combustion of
organic materials
TOBACCO ENGINE FOREST ASPHALT
SMOKE EXHAUST FIRES OVENS

14. DNA DAMAGE IN ROOFERS DUE TO PAH
EXPOSURE, POSSIBLE CANCER LINK
THIS STUDY COULD OPEN THE
PERSONAL DOOR FOR FORMULATE NEW
COMMENT POLITICS AND FOR TAKE NEW
BIOSECURITY RULES FOR THIS
WORKERS, ALWAYS LOOKING
FOR THE HEALTH AND FOR THE
WELFARE OF THE PEOPLE

15. MEDICAL UTILITY
MUTATION RATES IN CANCER CELLS STRONGLY
LINKED TO HOW CHROMATIN IS ORGANIZED
-KNOWING RELATIONSHIPS BETWEEN CHROMATIN AND
MUTATIONS CAN PREVENT DESEASES, MAKING STUDIES
ON PEOPLE WITH RISK BEFORE THEY DEVELOP THE
DESEASE, GIVING THEM MEDICINE AS A PROFILACTIC
MEASUREMENT

16. MEDICAL UTILITY
MUTATION RATES IN CANCER CELLS STRONGLY
LINKED TO HOW CHROMATIN IS ORGANIZED
-BY KNOWIG THE CAUSES OF THE CANCER, FINDING A
CURE ITS MORE EASY, AND KNOWING THE CAUSES IS
ALSO VERY USEFUL TU KNEW TREATMENTS LESS
AGRESSIVE THAN QUIMIO, FOR EXAMPLE

17. MEDICAL UTILITY
DNA DAMAGE IN ROOFERS DUE TO PAH
EXPOSURE, POSSIBLE CANCER LINK
IDENTIFY CARCINOGENIC SUSBTANCES IS REALLY IMPORTANT,
FOR REGULATING THEIR PRODUCTION AND THEIR
COMERCIALITATION IN SOME CASES, FOR PREVENTING
DEVELOPING NEW DESEASES AS FATAL AS CANCER

18. MEDICAL UTILITY
DNA DAMAGE IN ROOFERS DUE TO PAH
EXPOSURE, POSSIBLE CANCER LINK
SOME WORKS HAVE MORE RIKS THAN THE OTHERS, AND ITS VERY
IMPORTANT KOWING THE CAUSE OF THE RISK AND WHAT IS
PRODUCING THE RISK, SO THE WORKERS CAN FIND
MEASUREMENTS TO PROTECT THEMSELVES AND TO PROTECT
THE ENVIROMENT, FOR EXAMPLE, FINDING A WAY TO REDUCE TE
EXPOSURE TO PHAS

19. BIBLIOGRAPHY
DNA Damage in Roofers Due to PAH Exposure, Possible Cancer Link
Science Daily (July 26, 2012)
Mutation Rates in Cancer Cells Strongly Linked to How Chromatin Is
Organized
Science Daily (July 26, 2012)
MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín:
UPB. Fac. de Medicina, 2006. 208 p.