Just a quick view of combining two techniques to go a little deeper into the research of this disease

1. José Miguel Vicente Gomila, jmvicent@ingenio.upv.es
Co-fundador de TRIZ XXI y Profesor Asociado
de la Universidad Politécnica de Valencia
A Combination tech mining –
semantic TRIZ
About Hodgkin lymphoma
With help of de ISI WOS; Search tech's VantagePoint e IHS GoldFire

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With increasing quasi exponential appearance of research articles, how
do we know what is occuring specially in the surroundings of our
research speciality?
New therapies, new substances still with little presence, new
cobinations, synergies, etc?
This is a first incursion into the world of Hodgkin Lymphoma, open to the
contribution of willing researchers
First come a macro view and afterward we go little in deep

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Soruce ISI WOS all years; term: lymphoma. 20.206 arts. analyzed
Main authors and their weight.

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Main Institutions y their weight
Source ISI WOS all years; term: lymphoma. 20.206 arts. analyzed

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Source ISI WOS all years; term: lymphoma. 20.206 arts. analyzed
Large domains of research

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But to go to the concret, ¿Who is more
active with Rituximab?
20.206 arts. analyzed

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Main substances used to treat HL and their trend by years

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Some of the substances are new but show a good increase in use: are they
disruptive substances?

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Biology del Linfoma Hodgkins a partir de varias fuentes (ver debajo)
inform
reduces
proliferate
express
activate
proliferate
produce
induce
express
inhibit defense functions
produce
release
secrete
stimulate
activate
stimulate
increase presence
stimulate
impair availability
activate
stimulate
increase presence
stimulate
help survive
recruit
help survive
activate
attract help survive
attract
help survive
attract
attract
secrete
secrete
produce
prevent apoptosis
become
secrete
stimulate
passivate
passivate
activate
degradate
phosphorilate
activate
associate
activate
activate
control
carry
carry
stimulate
include
produce
kill
impair
induce
signal
destroy
induce
produce
attack
silence signalling
phosphorylate express
activate
detect
lymphocyte
T-cell
JAK2
Stat3
Reed Stenberg
cells
NF-kB
(NEMO,
IKK beta,
IKK alfa
apoptopic
protein
cell surface receptors including DDR2,
MSPR, TRKA y TRKB
Epstein-
Barr virus
and
TNFAIP3
TRAF
RIP
IKB alfa and beta
TNFAIP3
cytokine
antigen
activated B
cell
dark zone of the
germinal centre
CCL5 and
CCL22
eosinophils
basophils
mast cells
T-Lymphocyte
High Plasma
glucose
concentrations
insulin
ascorbic
acid
IGF1
Inflammatory
cytokine
IL-10, IL7
CD40, CD30 and
CD15
Notch 1
jagged
1
treg cells
HLA
Systemic view of biology of Hodgkin lymphoma based on the following sources:The Biology of Hodgkin's Lymphoma; Ralf Küppers,
www.webmd.com; Hodgkin lymphoma ; Fields P, Wrench D, Medicine 41:5; The microenvironment in classical Hodgkin lymphoma: an
actively dhaped and essential tumor component; Liu Y. et al ; Seminars in cancer biology 2013 (art in press) Springer Articles : From Basics
to Disease Jak-Stat Signaling, ISBN: 978-3-7091-0890-1; US-20120004169 A1 ; The EMBO Journal (2002) 21, 2159 – 2167
doi:10.1093/emboj/21.9.2159; Acute Myelogenous Leukemia Editors: Judith E. Karp MD ISBN: 978-1-58829-621-4 ; 2012 Nutrition, Diet
and Cancer Editors: Sharmila Shankar, Rakesh K. Srivastava ISBN: 978-94-007-2922-3
Done with the help of IHS GoldFire

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Example: in the previous system, cytokine secretion activates JAK2 and this
contributes to cancer: How to prevent cytokine secretion?
Done with the help of IHS
GoldFire
Substances or
méthods to
prevent
citokynes

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As Bendamustine is being used, what is people using bendamustine for?
Done with the help of IHS GoldFire