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February 2012




Pharmaceutical Sales and
Marketing Trends 2011
Key Insights
The Pharmaceutical Marketing and Sales Survey 2011 reflects the
views of more than 150 industry executives
                                                     Overview

 The Pharmaceutical Marketing and Sales Survey 2011 was designed to take the “industry temperature” with
  respect to current challenges, and to understand how industry leaders plan to overcome those challenges in the
  next several years

 Booz & Company and National Analysts Worldwide collaborated to gather and analyze online survey results
  from more than 150 pharmaceutical executives.
   – Respondents currently influence, or have responsibility for, commercial sales and/or marketing resources
     within their organization.
   – They are experienced, having held their positions for an average of five years: They are VPs (15%),
     directors (52%), and managers (20%).
   – Most are responsible for a product portfolio (46%) or a specific brand (33%).
   – Their responsibilities are primarily for in-line products (83%); the rest focus on products in late-stage clinical
     development (Phases II to III).

 All survey participants work in either the United States or one of the big five European Union countries, and they
  represent a diverse range of pharmaceutical companies.




                                                                                                                          1
68% of respondents believe that the current pharmaceutical model
is broken and needs significant repair
Q: Many people have raised the idea that the current commercial pharmaceutical model is broken and needs significant repair.
To what extent do you agree with this assessment?

                                        Is the Pharmaceutical Model Broken?
                                                    - % of Respondents -
                                                           (n=156)
   Fewer than 10% believe the model is not broken                             68% believe the model is broken


                                                                                 44%




                                                                                                       24%
                                                           22%




                                     6%
               3%

         Strongly Disagree         Disagree               Neutral               Agree             Strongly Agree


                                                                                                                           2
Respondents see significant challenges: Growing price pressure,
emphasis on cost-effectiveness, and more restrictive market access
  Q: Looking ahead, please rate how challenging you believe each of the following industry trends will be over the next
  two years.

                                                                           Upcoming Industry Challenges
                                                          [Challenges rated significant by >50% of respondents]
                                                                          - % of Respondents -
                        76%                                                      (n=156)
                                                      70%               69%
                                                                                                                   60%
                                                                                                                                                53%
                                                                                                                                                             50%




             Growing healthcare Growing need to                             More restrictive            Increasing generic                Decreasing       Patient
                system price/   demonstrate cost-                           market access                   competition                    sales-force   ability to pay
              budget pressures    effectiveness/                                                                                         access to MDs
                                    outcomes
Note: Challenges rated significant (4 or 5) by >50% of respondents; 1–2 = Insignificant challenges; 3 = Neutral; 4–5 = Significant challenges


                                                                                                                                                                          3
Many expect sales-force time for their products to decrease
  Q: Will the total amount of sales-force time that is allocated to your product(s) change over the next two years?

                                        Projected Change in Sales-Force Time Allocated to Primary Product
                                                                                       - % of Respondents -
                                                                                              (n=156)


                                                    Decrease                                                    Increase

                                                                                                                           Mean Projected
                                                                                                         26%               Increase = 58%


                     Mean Projected                                           43%
                     Decrease = 31%




                                                                                                      32%


                                                                                                               No Change



Note: Predictably, products slated for increase in SF time have longer mean patent life remaining


                                                                                                                                            4
Many also expect to shift spend from their current focus―
community MDs―toward key accounts, payors, and hospitals/GPOs
Q: How, if at all, do you believe the percent of sales and marketing expenditures allocated to these targets will change over the
next two years?

                      Projected Change in S&M Expenditure Allocation by Marketing Target
                                                      - % of Respondents -
                               Current                       (n=156)
                                Mean
                                                                          Projected Expenditure Trends
                             Expenditure

        Community MDs             29%                     32%                               49%                          19%


           Key Accounts           13%          3%                   50%                                     47%


    Key Opinion Leaders           11%               12%                         58%                                30%


             Other HCPs           10%            10%                            60%                                30%


         Hospitals/GPOs            9%           5%                        59%                                     36%


                  Payors           7%          2%                  51%                                      47%

                                                                      Decrease        No Change     Increase


                                                                                                                                5
Those who believe the model is broken plan to disproportionately reduce
spending on physicians and increase spending on nontraditional stakeholders
  Q: How, if at all, do you believe the percent of sales and marketing expenditures allocated to these targets will change over
  the next two years?
                                            Projected Change in S&M Expenditure Allocation by Marketing Target
                         (Comparison of planned spending between those who are convinced the model is broken and those who are not)
                                                                   - % of Respondents -
                                                         Projected Decrease                                   Projected Increase
                                                                                 -28%                    14%
                               Community MDs
                                                                             -35%                             21%


                                                                                          -4%                         38%
                                   Key accounts                                             -2%                             52%
                                                                                                                                      Respondents not
                                                                                                                                      convinced model is
                                                                                          -12%                  28%
                          Key opinion leaders                                                                                         broken1) (n=50)
                                                                                          -12%                      31%
                                                                                                                                      Respondents
                                                                                                                                      convinced model is
                                                                                           -10%                 26%                   broken2) (n=106)
                                     Other HCPs
                                                                                           -10%                     32%


                               Hospitals/GPOs                                             -4%             16%
                                                                                         -5%                              45%


                                               Payor                                            0%              28%
                                                                                           -3%                                  56%
1) Population represents those respondents who answered “Strongly Disagree,” “Disagree” or “Neutral” in Q29
2) Population represents those respondents who answered “Strongly Agree” or “Agree” in Q29


                                                                                                                                                           6
More than 50% of respondents expect to rely more on innovative pricing,
payor collaboration, pharmacoeconomic studies, and new service models

Q: How, if at all, do you anticipate that your reliance on the following marketing activities will change over the next two years?


                                                       Projected Change in Marketing Focus
                                                                   - % of Respondents -
                                                                          (n=156)
             Pricing Strategies
                                  6%                35%                                            59%

             Innovative Pricing   5%               36%                                             59%


         Payor Collaborations     6%                 38%                                            56%

  Pharmacoeconomic Studies                             37%
                                  8%                                                                 55%

          New Service Models      6%                     43%                                           51%


 Direct-to-Consumer Initiatives    9%                      43%                                           48%


            Patient Adherence     6%                       47%                                            47%

                                                  Decrease       No Change      Increase

                                                                                                                                     7
However, to date less than half of all respondents have engaged
with payors on their products prior to Phase III
 Q: Still thinking about the product on which you spend most of your time, how far in advance of launch [are/did] you
 initially [meeting/meet] with payors to discuss unmet needs and evidence required to support reimbursement?

                                                                                 Timing of Payor Engagement
                                                                        - % of Respondents by Product Responsibility -
                                                                                          (n=156)




                                  21%                                   24%                                      26%                                           29%



                        Prior to/During                    Between Phase II                        During Phase IIIa/b                                After Phase III
                           Phase II                          and Phase III




Note:
Phase I clinical trials focus on determining the safety of the compound for use in humans
Phase II clinical trials check for efficacy
Phase III clinical trials confirm safety and efficacy in large patient populations. IIIa trials are intended to support registration/regulatory approval. IIIb trials are started prior to approval, but are primarily
intended to support publications rather than registration or label changes.



                                                                                                                                                                                                                         8
More than 50% of respondents surveyed plan to respond with increased
spending on social media, mobile technologies, and e-detailing
  Q: How do you project your budget allocation for the following communications vehicles will change, if at all, over the next
  two years?

                                            Projected Change in Expenditures for Communication Vehicles
                                                                                        - % of Respondents -
                                                                                               (n=156)
                       MD-oriented Social Media                   8%               34%                                      58%
                                Mobile Technologies 6%                              39%                                       55%
                                              e-Detailing         8%                  40%                                       52%
                  MD-oriented Media Channels 7%                                       42%                                       51%
                    Search Engine Optimization 5%                                     46%                                        49%
                                                                                                                                                                                    Increase
                      Product/Disease Websites                     9%                    43%                                      48%
                                                                                                                                                                                    No Change
  Patient-oriented Social Media Platforms                         8%                     45%                                      47%
                                                                                                                                                                                    Decrease
              Video Conference Technologies                        9%                     46%                                       45%
             Patient-oriented Media Channels 4%                                          55%                                         41%
                            Patient Advocacy Sites 6%                                       57%                                         37%
                                                 Telereps          12%                            58%                                      30%
                   MD Print/Journal Advertising                               39%                                  42%                          19%

Note: Social media, mobile platforms, and e-detailing are all expected to see a boost in spending; even patient-focused social media – uncharted territory – is slated for investment


                                                                                                                                                                                                9
Booz & Company: creating and delivering essential advantage

                                                                                                              Europe
                                                                                                    Amsterdam           Istanbul          Paris
                                                                                                    Berlin              London            Rome
                                                                                                    Copenhagen          Madrid            Stockholm
Our Purpose:                                                      North America                     Dublin              Milan             Stuttgart
                                                                                                    Düsseldorf          Moscow            Vienna
                                                          Atlanta           Houston               Frankfurt           Munich            Warsaw
 To serve the senior agenda of the world’s leading       Chicago           Los Angeles           Helsinki            Oslo              Zurich
                                                          Cleveland         McLean                                                                      Asia
  institutions, public and private, by helping them       Dallas            Mexico City                                                               Beijing
                                                          DC                New York City                                                             Hong Kong
  to deal with their toughest challenges                  Detroit           Parsippany                          Middle East                           Seoul
                                                          Florham Park      San Francisco                                                             Shanghai
                                                                                                                     Abu Dhabi
                                                                                                                                                     
 We are recognized for the relevance of our                                                                         Beirut
                                                                                                                                                     
                                                                                                                                                         Taipei
                                                                                                                                                         Tokyo
                                                                                                                     Cairo
  ideas, the practical impact of our contributions,                                                                  Dubai
                                                                                    South America                    Riyadh
  the collaborative spirit of our people, and the                                                                                             Asia Pacific
                                                                                   Buenos Aires                                        Adelaide       Jakarta
  intrinsically global nature of our firm                                          Rio de Janeiro                                      Auckland       Kuala Lumpur
                                                                                   Santiago                                            Bangkok        Melbourne
                                                                                   São Paulo                                           Brisbane       Sydney
 And we succeed by being integral and essential                                                                                        Canberra
  to our clients’ success
                                                       Founded in 1914                                   Solely owned by its 200+
                                                                                                           officers
  To learn more about Booz & Company, visit:           More than
                                                        3,300 people             Our founder, Edwin Booz,
   booz.com                                                                      had the foresight to
   strategy-business.com                              57 offices in more than   start the management
    for our management magazine                         30 countries worldwide    consulting profession

©2012 Booz & Company Inc.




                                                                                                                                                                        10
ABOUT NATIONAL ANALYSTS WORLDWIDE




                                       National Analysts Worldwide is a unique consultancy that integrates sophisticated market
 Opportunity Assessment
                                       research methods with specialized healthcare industry expertise to guide important business
                                       decisions for manufacturers of healthcare solutions around the globe. Throughout a full
                                       century of business research leadership, including formation of the industry’s oldest specialized
 Innovation & Transformation          healthcare practice, the firm has played a pioneering role in the development of many of the
                                       tools that remain industry standards. We continue to offer clients not just the fruits of ongoing
                                       methodological evolution, but also a shrewd and pragmatic perspective on how and where to
                                       apply emerging techniques, including a full suite of advanced quantitative and qualitative
 Forecasting & Pricing                research services overseen by people who qualify as genuine industry thought leaders.

                                       Project leaders work closely with a team of in-house methodologists who customize our broad
                                       repertoire of choice modeling tools and software -- some of them proprietary -- in ways that
 Positioning & Communications         build opportunity for innovation and fresh thinking into every assignment. Types of
                                       engagements and marketing problems include opportunity assessment and forecasting, clinical
                                       trials design, pricing, portfolio strategy, segmentation, positioning, communications, and
                                       regulatory support. Our NAscence Bio-Innovation Group helps pharmaceutical companies,
 Segmentation & Targeting             large and small, spawn innovative products able to flourish in a challenging, high-stakes
                                       environment. The firm is also widely known for its integrated Farsight® forecasting and ROI
                                       models that reflect the interactions of multiple stakeholders and customers.
 Brand Strategy
                                       The firm’s balanced expertise in methods and marketing, its history of inventive thinking
                                       grounded in real world application, and the advantages of global reach with a cordial, boutique
                                       style of client service continue to distinguish us as leading candidates for assignments of
 Customer Experience                  strategic importance..




                          Healthcare  Financial Services  Communications|Technology|Media
                          Energy  Residential Design|Technology  Consumer Products  B2B

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Booz&co pharmaceutical sales & marketing trends-national-analysts-2011

  • 1. February 2012 Pharmaceutical Sales and Marketing Trends 2011 Key Insights
  • 2. The Pharmaceutical Marketing and Sales Survey 2011 reflects the views of more than 150 industry executives Overview  The Pharmaceutical Marketing and Sales Survey 2011 was designed to take the “industry temperature” with respect to current challenges, and to understand how industry leaders plan to overcome those challenges in the next several years  Booz & Company and National Analysts Worldwide collaborated to gather and analyze online survey results from more than 150 pharmaceutical executives. – Respondents currently influence, or have responsibility for, commercial sales and/or marketing resources within their organization. – They are experienced, having held their positions for an average of five years: They are VPs (15%), directors (52%), and managers (20%). – Most are responsible for a product portfolio (46%) or a specific brand (33%). – Their responsibilities are primarily for in-line products (83%); the rest focus on products in late-stage clinical development (Phases II to III).  All survey participants work in either the United States or one of the big five European Union countries, and they represent a diverse range of pharmaceutical companies. 1
  • 3. 68% of respondents believe that the current pharmaceutical model is broken and needs significant repair Q: Many people have raised the idea that the current commercial pharmaceutical model is broken and needs significant repair. To what extent do you agree with this assessment? Is the Pharmaceutical Model Broken? - % of Respondents - (n=156) Fewer than 10% believe the model is not broken 68% believe the model is broken 44% 24% 22% 6% 3% Strongly Disagree Disagree Neutral Agree Strongly Agree 2
  • 4. Respondents see significant challenges: Growing price pressure, emphasis on cost-effectiveness, and more restrictive market access Q: Looking ahead, please rate how challenging you believe each of the following industry trends will be over the next two years. Upcoming Industry Challenges [Challenges rated significant by >50% of respondents] - % of Respondents - 76% (n=156) 70% 69% 60% 53% 50% Growing healthcare Growing need to More restrictive Increasing generic Decreasing Patient system price/ demonstrate cost- market access competition sales-force ability to pay budget pressures effectiveness/ access to MDs outcomes Note: Challenges rated significant (4 or 5) by >50% of respondents; 1–2 = Insignificant challenges; 3 = Neutral; 4–5 = Significant challenges 3
  • 5. Many expect sales-force time for their products to decrease Q: Will the total amount of sales-force time that is allocated to your product(s) change over the next two years? Projected Change in Sales-Force Time Allocated to Primary Product - % of Respondents - (n=156) Decrease Increase Mean Projected 26% Increase = 58% Mean Projected 43% Decrease = 31% 32% No Change Note: Predictably, products slated for increase in SF time have longer mean patent life remaining 4
  • 6. Many also expect to shift spend from their current focus― community MDs―toward key accounts, payors, and hospitals/GPOs Q: How, if at all, do you believe the percent of sales and marketing expenditures allocated to these targets will change over the next two years? Projected Change in S&M Expenditure Allocation by Marketing Target - % of Respondents - Current (n=156) Mean Projected Expenditure Trends Expenditure Community MDs 29% 32% 49% 19% Key Accounts 13% 3% 50% 47% Key Opinion Leaders 11% 12% 58% 30% Other HCPs 10% 10% 60% 30% Hospitals/GPOs 9% 5% 59% 36% Payors 7% 2% 51% 47% Decrease No Change Increase 5
  • 7. Those who believe the model is broken plan to disproportionately reduce spending on physicians and increase spending on nontraditional stakeholders Q: How, if at all, do you believe the percent of sales and marketing expenditures allocated to these targets will change over the next two years? Projected Change in S&M Expenditure Allocation by Marketing Target (Comparison of planned spending between those who are convinced the model is broken and those who are not) - % of Respondents - Projected Decrease Projected Increase -28% 14% Community MDs -35% 21% -4% 38% Key accounts -2% 52% Respondents not convinced model is -12% 28% Key opinion leaders broken1) (n=50) -12% 31% Respondents convinced model is -10% 26% broken2) (n=106) Other HCPs -10% 32% Hospitals/GPOs -4% 16% -5% 45% Payor 0% 28% -3% 56% 1) Population represents those respondents who answered “Strongly Disagree,” “Disagree” or “Neutral” in Q29 2) Population represents those respondents who answered “Strongly Agree” or “Agree” in Q29 6
  • 8. More than 50% of respondents expect to rely more on innovative pricing, payor collaboration, pharmacoeconomic studies, and new service models Q: How, if at all, do you anticipate that your reliance on the following marketing activities will change over the next two years? Projected Change in Marketing Focus - % of Respondents - (n=156) Pricing Strategies 6% 35% 59% Innovative Pricing 5% 36% 59% Payor Collaborations 6% 38% 56% Pharmacoeconomic Studies 37% 8% 55% New Service Models 6% 43% 51% Direct-to-Consumer Initiatives 9% 43% 48% Patient Adherence 6% 47% 47% Decrease No Change Increase 7
  • 9. However, to date less than half of all respondents have engaged with payors on their products prior to Phase III Q: Still thinking about the product on which you spend most of your time, how far in advance of launch [are/did] you initially [meeting/meet] with payors to discuss unmet needs and evidence required to support reimbursement? Timing of Payor Engagement - % of Respondents by Product Responsibility - (n=156) 21% 24% 26% 29% Prior to/During Between Phase II During Phase IIIa/b After Phase III Phase II and Phase III Note: Phase I clinical trials focus on determining the safety of the compound for use in humans Phase II clinical trials check for efficacy Phase III clinical trials confirm safety and efficacy in large patient populations. IIIa trials are intended to support registration/regulatory approval. IIIb trials are started prior to approval, but are primarily intended to support publications rather than registration or label changes. 8
  • 10. More than 50% of respondents surveyed plan to respond with increased spending on social media, mobile technologies, and e-detailing Q: How do you project your budget allocation for the following communications vehicles will change, if at all, over the next two years? Projected Change in Expenditures for Communication Vehicles - % of Respondents - (n=156) MD-oriented Social Media 8% 34% 58% Mobile Technologies 6% 39% 55% e-Detailing 8% 40% 52% MD-oriented Media Channels 7% 42% 51% Search Engine Optimization 5% 46% 49% Increase Product/Disease Websites 9% 43% 48% No Change Patient-oriented Social Media Platforms 8% 45% 47% Decrease Video Conference Technologies 9% 46% 45% Patient-oriented Media Channels 4% 55% 41% Patient Advocacy Sites 6% 57% 37% Telereps 12% 58% 30% MD Print/Journal Advertising 39% 42% 19% Note: Social media, mobile platforms, and e-detailing are all expected to see a boost in spending; even patient-focused social media – uncharted territory – is slated for investment 9
  • 11. Booz & Company: creating and delivering essential advantage Europe  Amsterdam  Istanbul  Paris  Berlin  London  Rome  Copenhagen  Madrid  Stockholm Our Purpose: North America  Dublin  Milan  Stuttgart  Düsseldorf  Moscow  Vienna  Atlanta  Houston  Frankfurt  Munich  Warsaw  To serve the senior agenda of the world’s leading  Chicago  Los Angeles  Helsinki  Oslo  Zurich  Cleveland  McLean Asia institutions, public and private, by helping them  Dallas  Mexico City  Beijing  DC  New York City  Hong Kong to deal with their toughest challenges  Detroit  Parsippany Middle East  Seoul  Florham Park  San Francisco  Shanghai  Abu Dhabi   We are recognized for the relevance of our  Beirut  Taipei Tokyo  Cairo ideas, the practical impact of our contributions,  Dubai South America  Riyadh the collaborative spirit of our people, and the Asia Pacific  Buenos Aires  Adelaide  Jakarta intrinsically global nature of our firm  Rio de Janeiro  Auckland  Kuala Lumpur  Santiago  Bangkok  Melbourne  São Paulo  Brisbane  Sydney  And we succeed by being integral and essential  Canberra to our clients’ success  Founded in 1914  Solely owned by its 200+ officers To learn more about Booz & Company, visit:  More than 3,300 people  Our founder, Edwin Booz,  booz.com had the foresight to  strategy-business.com  57 offices in more than start the management for our management magazine 30 countries worldwide consulting profession ©2012 Booz & Company Inc. 10
  • 12. ABOUT NATIONAL ANALYSTS WORLDWIDE National Analysts Worldwide is a unique consultancy that integrates sophisticated market  Opportunity Assessment research methods with specialized healthcare industry expertise to guide important business decisions for manufacturers of healthcare solutions around the globe. Throughout a full century of business research leadership, including formation of the industry’s oldest specialized  Innovation & Transformation healthcare practice, the firm has played a pioneering role in the development of many of the tools that remain industry standards. We continue to offer clients not just the fruits of ongoing methodological evolution, but also a shrewd and pragmatic perspective on how and where to apply emerging techniques, including a full suite of advanced quantitative and qualitative  Forecasting & Pricing research services overseen by people who qualify as genuine industry thought leaders. Project leaders work closely with a team of in-house methodologists who customize our broad repertoire of choice modeling tools and software -- some of them proprietary -- in ways that  Positioning & Communications build opportunity for innovation and fresh thinking into every assignment. Types of engagements and marketing problems include opportunity assessment and forecasting, clinical trials design, pricing, portfolio strategy, segmentation, positioning, communications, and regulatory support. Our NAscence Bio-Innovation Group helps pharmaceutical companies,  Segmentation & Targeting large and small, spawn innovative products able to flourish in a challenging, high-stakes environment. The firm is also widely known for its integrated Farsight® forecasting and ROI models that reflect the interactions of multiple stakeholders and customers.  Brand Strategy The firm’s balanced expertise in methods and marketing, its history of inventive thinking grounded in real world application, and the advantages of global reach with a cordial, boutique style of client service continue to distinguish us as leading candidates for assignments of  Customer Experience strategic importance.. Healthcare  Financial Services  Communications|Technology|Media Energy  Residential Design|Technology  Consumer Products  B2B