this presentation include info for stater students and have basic knowledge of pro pro interaction

2.  Ayesha Aftab Malik
 Amber Malik

3.  Proteins are the workhorses that facilitate
most biological processes in a cell.

12.  The majority of proteins interact with
other proteins for proper function
 Publication of the human genome
 Development of the field of proteomics,

13. Two types
 Stable
 Transient
 Both types can be weak or strong

14.  Alter the kinetic properties of enzymes
 Allow for substrate channeling
 Create a new binding site
 Inactivate or destroy a protein
 Change the specificity of a protein for
interaction with different proteins
 Serve a regulatory role

17. Slow
Time consuming
Not accurate
Difficult to handle
Costly
Lack of equipments

18. Primary databases
Int act
Mint
Bind
string
Meta databases
PINA
APIP

19.  STRING:
 known and predicted protein interactions.
Interactions physical and functional
associations
 The database currently covers 5'214'234
proteins from 1133 organisms.

20.  K VOTE
 to create seven different integrated
networks by using values of k ranging
from 1-7.
 modularity, similarity-based modularity,
clustering score, enrichment.

22.  Proteins rarely act alone