CLINICAL AND EXPERIMENTAL RESEARCH IN CARDIOLOGY

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Journal of Clinical and Experimental Research in Cardiology (JCERC) is an international open access, scholarly peer-reviewed journal publishing high quality articles in all areas of cardiology related fields, especially current research, new concepts, novel methods, new therapeutic agents, and approaches for early detection and prevention of cardiac disorders and reporting new methods on basic and advanced clinical aspects of cardiology research.

Ciencias

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ABOUT THE JOURNAL
Journal of Clinical and Experimental Genetics (JCEG) is an
peer-reviewed, open access journal that publishes original
research articles, review articles, and case reports in all
areas of genetics. Clinical and Experimental Genetics is the
medical specialty which provides a diagnostic
service and "genetic counseling" worldwide. It covers all
the aspects of Chromosomal abnormalities, Single gene
disorders such as cystic fibrosis, muscular dystrophy,
Huntington's disease and sickle cell disease. It publishes
the best quality scientific articles amalgamating broad
varieties of fields together with the fields associated with
Clinical and Experimental Genetics.

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AIMAND SCOPE
Journal of Clinical and Experimental Genetics (JCEG) aims to publish
latest research articles and serve the scientific community by exploring
the ideas of the scientific researchers at the same time strive to publish
quality articles, it is a global peer-reviewed journal targeted on
publishing original contributions and review articles from all the fields of
genetics. It provides information to those who are affected by, or at a risk
of, a genetic disorders and the methods to rectify through the
experimental genetics.
The following are the major fields, but are not restricted:
 DNA
 RNA
 Chromosomes
 Heredity
 Genealogy
 Interaction of multiple genes
 Genetic code
 Pseudo gene
 Gene expression
CLICK HERE TO VIEW MORE

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EDITORIAL BOARD
NIKOLAI N. MODYANOV NICHOLAS TSINOREMAS
AZAD KUMAR KAUSHIK HASSEN CHAABANI
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 Each Editor of the Editorial Board plays a crucial role in
maintaining the standards of the journal and peer
review. Editor of a journal should take the sole
responsibility for its reputation and entire content.
 Based on the field of research (or) subject, editor will
assign submitted manuscript to a reviewer for the peer
review process
 If that particular reviewer accepts to review the article
then the author shall notify Annex Publishers the same,
if not it shall be forwarded to another editor in the same
field

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The Editors are requested to send the
acknowledgement to respective author after
he/she receives the article
This should be provided within a short period
where it would be helpful to the author for an
update on the paper's status
If the articles do not meet the policies of
submission it would likely to be rejected
Articles meeting the minimum criteria will be sent
to the reviewers for review after which the Editors
will approach the reviewers with the title and
abstract.
Reviewers will be asked to review the manuscript
within the deadline i.e., 14 days

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Author(s) are requested to submit the manuscripts, in accordance with
the following format which would help in easy review by the Editorial
Board (EB) members.
 Title
 Author(s) with affiliations
 Abstract
 Introduction
 Mainbody / Methods
 Results & Discussions
 Conclusions
 List of abbreviations used or keywords
 Acknowledgments
 References
 Tables and figures
 Supplementary information

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MANUSCRIPT SUBMISSION FORM
SUBMIT MANUSCRIPT
Please do go through our manuscript Instructions and
Guide lines before submitting a manuscript, kindly read
them carefully. Manuscripts/ Articles must be submitted
in accordance with guidelines. Articles that are not in the
required format would likely to be rejected.
CLICK HERE TO SUBMIT THE MANUSCRIPT
For queries contact us jceg@annexpublishers.com

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Abstract The application of legal knowledge to psychiatry and of psychiatric knowledge to the legal issues is the subspecialty of psychiatry known as forensic psychiatry. In India, forensic psychiatry is still in its infancy. The legal issues pertaining to the mental health care in India appeared only after British Rule, with very minimal changes occurring post independence. Currently, the training of psychiatry postgraduates to the idea of an interface between law and psychiatry is poor. It is neglected, ignored, misinterpreted and misunderstood. To meet the standards of the developed world and international covenants, there is a pressing need by psychiatric community in the region to understand the existing legislation and to initiate changes through various agencies and regulatory bodies. This paper attempts to elucidate the interface of law and psychiatry in India in a nutshell.

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Background: Studies have shown that a significant proportion of university students globally suffer from stress. Although many studies have reported an association between psychological stress and dietary behaviour, findings remain inconclusive. To date, no research in Kuwait has assessed the prevalence of stress and its relationship with dietary pattern among university students. Objectives: This study was designed to determine the extent of stress among undergraduate students in Kuwait University and to examine the relationship between dietary behaviours and stress. Methods: A total of 407 (164 males and 243 females) undergraduate students, aged ≥ 18 years, from 4 colleges of Kuwait University participated in this cross sectional study. Data were collected using a self-administered questionnaire consisting of three sections: socio demographic information, stress measures and a 7-day food frequency questionnaire. Results: Of the total participants, 43% were found to suffer from some level of stress, with slightly more females (44%) than males (40.9%). When examined the severity of stress level, 28.4% of the females and 22% of the males had moderate to severe form of stress. Stressed female students were more likely to eat fast foods (OR 1.75; 95% CI: 1.02-3:00), snacks (OR 2.0; 95% CI: 1.16-3:43) and beverages (OR 2.28; 95% CI: 1.30-3.98) than unstressed female students. For male students, none of the food consumption groups were associated with stress. Conclusions: These results show a clear difference in food selection patterns between stressed male and female students with stress being strongly associated with unhealthy food selection among female students than male students. These findings emphasize the importance for the development of specific intervention programs to decrease stress and improve healthy behaviour especially among female university students and thus reduce the potential negative implications of stress on health.

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Abstract In response to the rapidly rising intravenous opioid abuse epidemic, the United States Food and Drug Administration is currently promoting the development of prescription opioid tablets that are specifically formulated to deter abuse. Opana ER®; (Endo Pharmaceuticals) recently underwent reformulation to include a crush-resistant coating. Only recently described, illicit intravenous injection of reformulated Opana ER®; is associated with a distinctive clinical syndrome of thrombotic microangiopathy. Ten patients with the appropriate history and presenting symptoms were identified within an 8 month interval (July 2012 through February 2013) at the University of Tennessee Medical Center (UTMC) Knoxville with ICD-9 code of 446.6 (thrombotic microangiopathy) by electronic search. Review of laboratory data, electronic medical records, blood product usage, and total hospital admission charges were compiled for these individual patients. We report the clinicopathologic findings and correlating laboratory data for a group of patients presenting with thrombotic microangiopathy and documented recent history of intravenous Opana ER®; injection. We also report the economic impact and effect on blood product utilization by this study group.

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Abstract The objectives of this retrospective study were 1. To determine the effect of three surgical techniques (right flank omentopexy, right flank omentoabomasopexy, and left flank abomasopexy), and 2. To determine the effect of concurrent disease on return to normal milk production. Return to normal milk production occurred in 86.3% of cows diagnosed with LDA. Results suggested that cattle diagnosed with LDA corrected via right flank omentopexy or left flank abomasopexy were significantly more likely to return to normal milk production as compared to those corrected via right flank omentoabomasopexy (p< 0.02). No significant difference in return to normal milk production was noted between surgical techniques for correction of RDA (p=1.000) and right abomasal volvulus (p=0.596). Concurrent disease diagnoses did not affect return to milk production. Reported complications were infrequent (n=11). List of abbreviations: LDA- Left displaced abomasum; RDA- Right displaced abomasum; RAV- Right abomasal volvulus; RAOV- Right abomasal-omasal volvulus; RFO- Right flank omentopexy; RFOA- Right flank omentoabomasopexy; LFA- Left flank abomasopexy; DA – Displaced Abomasum

Outcome following-surgical-correction-of-abomasal-displacement-in-lactating-d...

Annex Publishers

Abstract Three surgical case reports are presented to demonstrate the clinical efficacy of using an improved aqueous solution of chlorine dioxide complex (160 ppm) as a topical antiseptic in the post operative management of serious wounds in dogs. In vitro studies are included to demonstrate the antiseptic properties of this new chlorine dioxide complex. Keywords: Chlorine dioxide; Antiseptic; Antimicrobial; Wound management Abbreviations: ClO2-Chlorine dioxide; Cl2-Chlorine; PPM-Parts Per Million; SPP-Species; TEM-Transmission Electron Micrograph

Surgical wound-management-in-dogs-using-an-improved-stable-chlorine-dioxide-a...

Annex Publishers

Abstract Salmonella is a causative agent for a wide variety of pathological diseases in humans, cattle, poultry and other farm animals and hence Salmonella infections are a major cause of concern to humans, veterinary animals and to food industry. With characterization of over 2500 Salmonella serovars, the pathogen nearly infects all vertebrates but the severity of infection varies from one serovar to another depending upon their host specificity. Some Salmonella serovars are restricted to one or few hosts while others have a broad host spectrum. Thus the understanding of the mechanisms involving host preference by one serovar over another is very important. As our knowledge about host adaptability will then be instrumental in designing better vaccines. Furthermore, methods involving identification of genetic markers for host specificity will prove to be instrumental in determining virulence factors for other pathogenic bacteria that cause systemic infections. Keywords: Host adaption; Evolution; Salmonella serovar; Horizontal gene transfer

Salmonella serovars-and-their-host-specificity

Annex Publishers

Abstract The objective of this investigation was to evaluate the efficacy and safety of purified Shilajit in moderately arthritic dogs. Ten client-owned dogs in a randomized double-blinded study received either a placebo or Shilajit (500 mg) twice daily for a period of five months. Dogs were evaluated each month for physical condition (body weight, body temperature, heart rate, and respiration rate) and pain associated with arthritis (overall pain, pain from limb manipulation, and pain after physical exertion). Serum samples collected from these dogs were examined each month for biomarkers of liver (bilirubin, ALT, and AST), kidney (BUN and creatinine) heart and muscle (creatine kinase) functions. The findings of this study revealed that dogs receiving Shilajit (Group-II) showed a significant (P< 0.05) reduction in pain from limb manipulation by day 60, and overall pain and pain after physical exertion by day 120. Maximum pain reduction, using all three criteria, was observed on day 150. Pain level remained significantly unchanged in dogs receiving the placebo. Dogs in either group showed no significant change (P>0.05) in physical parameters or serum markers, suggesting that Shilajit was well tolerated by moderately arthritic dogs. It was concluded that Shilajit significantly (P< 0.05) reduced pain in osteoarthritic dogs and markedly improved their daily life without any side effects. Keywords: Purified Shilajit; Osteoarthritis in canine; Shilajit safety; Anti-arthritic nutraceutical

Anti inflammatory-and-anti-arthritic-efficacy-and-safety-of-purified-shilajit...

Annex Publishers

The discovery of the presence of stem cells and precursors with high regenerative potential in the mammary gland, hypothetically maintained throughout the course of the productive life of the dairy cow sheds an interesting perspective in the research which is interested to clarify all physiological clues and possible solutions to increase or maintain longer the potential production of dairy cows during life span of lactation. In 2006, Connie Eaves' lab in Vancouver (Stingl et ., 2006) [1]

Adults mammary-stem-cell-in-cows-milk-new-perspectives-and-future-challenge

Annex Publishers

Abstract Mitogen-Activated Protein Kinase (MAPK) pathway is a signal transduction pathway that functions in a wide range of physiological and pathophysiological cellular events including cell proliferation, differentiation, apoptosis, migration, inflammation, metabolic disorders and diseases. In skeletal muscle, it plays an essential role in muscle fiber specialization, muscle mass maintenance, damage induced muscle regeneration and muscle diseases. This review provides an overview of MAPK pathway and its pathophysiological role in skeletal muscle diseases with a primary focus on muscular dystrophy and atrophy.

MAPK Pathway in Skeletal Muscle Diseases

Annex Publishers

Abstract An examination experiment has been carried out to investigate whether fingerprint powder and lifting technique can recover and transfer latent fingerprints from human skin surfaces of dead bodies. For recovery Swedish Black powder and for transfer White Fingerprint Gelatine were used. Donors placed fingerprints on the human skin surfaces. Finger marks were then in all cases recovered with Swedish Black powder. The procedure was repeated after 2, 3, 4 and 5 hours. Treated finger marks were secured and preserved as latent fingerprint evidence by lifting process. We recovered 8% finger marks suitable for further examination of all deposited samples on the human skin surfaces.

Fingerprint recovery-from-human-skin-by-finger-powder

Annex Publishers

Abstract Human origin determination is an important aspect of blood grouping analysis in forensic science laboratories. In the present study, protein extractants like gel buffer, ammonia and saline employed for origin determination were evaluated and compared qualitatively and quantitatively for their role in the extraction of proteins from dried blood stained materials of human origin at regular time intervals. Qualitative and quantitative methods employing counter immunoelectrophoresis (CIE) and rocket immunoelectrophoresis (RIE) respectively were used to study the protein extraction efficiency of extractants. Ammonia, compared to gel buffer and saline extracted the proteins effectively. Maximum extraction of proteins was observed in 2-3 hours of sample. CIE demonstrated sharp precipitin bands with all samples of ammonia extractant compared to the samples of counterparts. RIE also revealed greater concentration of proteins in the ammonia extract compared to extracts of gel buffer and saline. These results provide evidence that ammonia serves as a better protein extractant for rapid determination of human blood origin. Keywords: Forensic science; Forensic serology; Blood origin; Electrophoresis; Protein extractants; Immunoprecipitation

Study on-efficiency-of-protein-extractants-employed-for-human-origin-determin...

Annex Publishers

Abstract A person's stature is an identifying characteristic that is often used in forensic investigation. Footprint is the one of the valuable physical evidence encountered in the crime scenes and examination of barefoot impressions is important especially in developing countries like India, Malaysia where majority of the rural population like to walk barefooted because of socio-economic and climatic reasons. Foot impressions are still found at crime scenes, since offenders often tend to remove their footwear either to avoid noise or to gain better grip in climbing walls, etc., while entering or exiting. Most of the foot/foot print studies were conducted on mixed population. The researchers have cautioned that the people from different races and regions of a country bear different morphological features depending upon their geographical distribution and primary racial characteristics and hence a single formula cannot represent all parts of that country or world. The present study aims to estimate stature from bilateral footprints collected from 320 (160 males, 160 females) consenting adult Ibans, an indigenous group residing in Sarawak state, east Malaysia. Informed consent and Human Ethical Approval were obtained. The height of the individuals and footprints were collected following the standard procedure. The data obtained were analyzed with PASW 20 computer software and derived regression formulae to estimate stature from footprint lengths of Iban ethnics. The result of the investigation revealed that all footprint lengths exhibit statistically positive significant correlation with stature (p< 0.001). Correlation coefficient (R) values are found to be higher in the pooled sample (0.861–0.887) when compared with males (0.753–0.789) and females (0.728–0.790). The regression formulae derived for the pooled sample can be used to estimate stature when the sex of the footprint remains unknown, as in real crime scenarios.

Stature estimation-from-the-anthropometric-measurements-of-footprint-in-iban-...

Annex Publishers

Abstract Programming scripts were written for the statistical analysis of genetic data from simple cases and complex cases of undetermined paternity. The methods presented here involve algorithms constructed with R, an open-source and increasingly popular programming language used for calculations and statistics; these methods also involve conditional probability analysis, Bayes’ Theorem, and pedigree analysis. Previous computer programs for assessing probable paternity in complex cases of undetermined paternity have been written; however, only minimal or generalized formulas are described in the papers presenting these programs. Therefore, these previously published programs are difficult to understand for most forensic researchers. Here, we present the details of the calculations used to evaluate probabilities of paternity and the details of the R scripts used execute these calculations. These scripts were constructed not only for standard trio case where DNA typing of the mother, child, and the alleged father are available, but also for more complex cases where DNA typing of the alleged father is absent. In these more complex cases, the putative genotype of the alleged father is determined from the genotypes of his parents, his siblings, his wife, children known to be his biological children, or some combination of these people. This report provides concrete and orderly descriptions of the calculations and the R scripts so that each facet of this method is easily understood. Furthermore, access to these scripts will enable individual researchers to develop calculation systems of their own. Keywords: Forensic mathematics; Paternity testing; R; DNA typing

Programming scripts-for simple-and-complex-paternity-testing-based-on-open-so...

Annex Publishers

Abstract This paper discusses the psychosexual correlations and psychological consequences related to torture and behavioral acts that are fundamentally torturous. The influence of participation by learning and the relationship of acts to thought and thought to acts are further discussed to raise awareness to the effects of torture on the torturer. Theories from multiple disciplines are presented in an integrated context to examine the correlation between fundamental psychological principles associated with acts that are torturous in nature and, therefore, innately evil. Keywords: Aggression; Crime; Criminology; Behavioral acts; Human behavior; Psychological effects; Psychology; Psychopathology; Psychosexual; Sex; Sex crimes; Sexuality; Torture; Violence

Tame to-torture-psychosexual-correlations-of-sex-violence-and-torture

Annex Publishers

48-years old man was found dead at home, lying in his bed. There was a bucket with liquid vomited remnants with no addition of fresh or digested blood found near the bed and an empty bottle of alkaline mineral water often used to attenuate the gastric pain. Up to the information from the man's relative, he was a chronic alcohol consumer, being last seen alive the day before in the pub, drinking small amount of beer. His personal anamnesis was negative for the previous injuries or any pathological entity which could have potential fatal outcome. External observation of the body did not uncover any signs of mechanical violence on the body. The only pathological findings at the autopsy were: very mild generalised atherosclerosis without stenosis of blood vessels, configuration of the heart with the weight of 400 g was physiological, with no signs of chronic venostatic changes on the internal organs.

The fatal-alcoholic ketoacidosis-as-a-dilemma-in-the-differential-diagnosis-i...

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JOURNAL OF FORENSIC SCIENCE & CRIMINOLOGY

Annex Publishers

Abstract The synthetic cannabinoid, N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide, known also as AKB48 and/or APINACA, has been detected for the first time in herbal incense seized in Italy. Its structural characterization has been performed through gas chromatography-mass spectrometry (GC-MS) and high-resolution nuclear magnetic resonance (NMR) analysis. In order to favor an easier and faster identification of AKB48 in future investigations, NMR assignments in deuterated methanol and chloroform is also reported. Keywords: NMR; GC-MS; Designer drug; Synthetic cannabinoid; Herbal incense

Nmr assignment-of-n-(1-adamantyl)-1-pentyl-1 h-indazole-3-carboxamide-seized-...

Annex Publishers

Abstract We present an indoor forensic case that occurred in spring 2013 in Cosenza (southern Italy). The entomological evidence collected at the scene consisted of Calliphoridae (Calliphora vicina, Lucilia sericata), Sarcophagidae (Sarcophaga crassipalpis), Fanniidae (Fannia scalaris) and Muscidae (Hydrotaea ignava). The minimum Post Mortem Interval (mPMI) was calculated by relating the entomological evidence to data available for Diptera species in the area and to our knowledge of the development of flies used as forensic indicators in Calabria. We report S. crassipalpis as a corpse invader for the first time in Italy. Keywords: Forensic case; Flies; S. crassipalpis; mPMI; Southern Italy

The flesh-fly-sarcophaga-(liopygia)-crassipalpis-macquart-1839-as-an-invader-...

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Biometrics and Its Applications (JBIA)

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JOURNAL OF VETERINARY SCIENCE & ANIMAL HUSBANDRY

Anti arthritic-efficacy-and-safety-of-crominex-3+(trivalent-chromium-phyllant...

Outcome following-surgical-correction-of-abomasal-displacement-in-lactating-d...

Surgical wound-management-in-dogs-using-an-improved-stable-chlorine-dioxide-a...

Salmonella serovars-and-their-host-specificity

Anti inflammatory-and-anti-arthritic-efficacy-and-safety-of-purified-shilajit...

Adults mammary-stem-cell-in-cows-milk-new-perspectives-and-future-challenge

MAPK Pathway in Skeletal Muscle Diseases

Fingerprint recovery-from-human-skin-by-finger-powder

Study on-efficiency-of-protein-extractants-employed-for-human-origin-determin...

Stature estimation-from-the-anthropometric-measurements-of-footprint-in-iban-...

Programming scripts-for simple-and-complex-paternity-testing-based-on-open-so...

Tame to-torture-psychosexual-correlations-of-sex-violence-and-torture

The fatal-alcoholic ketoacidosis-as-a-dilemma-in-the-differential-diagnosis-i...

JOURNAL OF FORENSIC SCIENCE & CRIMINOLOGY

Nmr assignment-of-n-(1-adamantyl)-1-pentyl-1 h-indazole-3-carboxamide-seized-...

The flesh-fly-sarcophaga-(liopygia)-crassipalpis-macquart-1839-as-an-invader-...

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Ultrasound color Doppler imaging has been routinely used for the diagnosis of cardiovascular diseases, enabling real-time flow visualization through the Doppler effect. Yet, its inability to provide true flow velocity vectors due to its one-dimensional detection limits its efficacy. To overcome this limitation, various VFI schemes, including multi-angle beams, speckle tracking, and transverse oscillation, have been explored, with some already available commercially. However, many of these methods still rely on autocorrelation, which poses inherent issues such as underestimation, aliasing, and the need for large ensemble sizes. Conversely, speckle-tracking-based VFI enables lateral velocity estimation but suffers from significantly lower accuracy compared to axial velocity measurements. To address these challenges, we have presented a speckle-tracking-based VFI approach utilizing multi-angle ultrafast plane wave imaging. Our approach involves estimating axial velocity components projected onto individual steered plane waves, which are then combined to derive the velocity vector. Additionally, we've introduced a VFI visualization technique with high spatial and temporal resolutions capable of tracking flow particle trajectories. Simulation and flow phantom experiments demonstrate that the proposed VFI method outperforms both speckle-tracking-based VFI and autocorrelation VFI counterparts by at least a factor of three. Furthermore, in vivo measurements on carotid arteries using the Prodigy ultrasound scanner demonstrate the effectiveness of our approach compared to existing methods, providing a more robust imaging tool for hemodynamic studies. Learning objectives: - Understand fundamental limitations of color Doppler imaging. - Understand principles behind advanced vector flow imaging techniques. - Familiarize with the ultrasound speckle tracking technique and its implications in flow imaging. - Explore experiments conducted using multi-angle plane wave ultrafast imaging, specifically utilizing the pulse-sequence mode on a 128-channel ultrasound research platform.

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CLINICAL AND EXPERIMENTAL RESEARCH IN CARDIOLOGY

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2. www.annexpublishers.com ABOUT THE JOURNAL Journal of Clinical and Experimental Genetics (JCEG) is an peer-reviewed, open access journal that publishes original research articles, review articles, and case reports in all areas of genetics. Clinical and Experimental Genetics is the medical specialty which provides a diagnostic service and "genetic counseling" worldwide. It covers all the aspects of Chromosomal abnormalities, Single gene disorders such as cystic fibrosis, muscular dystrophy, Huntington's disease and sickle cell disease. It publishes the best quality scientific articles amalgamating broad varieties of fields together with the fields associated with Clinical and Experimental Genetics.

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