The purpose of a temperature controlled package is to maintain an interior thermal environment sufficient to meet the product’s temperature requirements. Refrigerant packs in combination with insulated containers make up the bulk of temperature controlled packages. The most commonly employed refrigerant material is water often with some additives to alter its properties.

1. Use of Engineered Phase Change Materials in Cold Chain Packaging Design Presented By: Anthony Alleva Technical Services Manager, TCP Reliable, Inc . Healthcare Packaging Conference & Workshops May 27, 2010 Leveraging New Refrigerant Technologies

18. Photo of Cube Test Set-Up

19. Result for Freezing

20. Result for Melting

25. Dry Ice Performance Example

28. Insulation Quality vs. Time

31. Results for Combination Experiment

33. Temperature Range: Below –20°C (Dry Ice) EPS Lid EPS Collar with cut out for monitor EPS Product Housing Outer EPS Trough Housing Lower EPS Collar EPS Bottom Outer shipper with EPS

34. Temperature Range: –40°C to –20°C EPS Lid Corrugate Divider -20°C PCM Dry Ice -20°C PCM Outer shipper with EPS

35. Temperature Range: 2°C to 8°C EPS Lid Refrigerated Water Gels Frozen Water Gels Payload Carton Outer shipper with EPS Frozen Water Gels

36. Temperature Range: 2°C to 8°C EPS Lid Water Gels 5°C PCM Outer shipper with dual chamber EPS walls

37. Temperature Range: 15°C to 30°C EPS Lid 22°C PCM Outer shipper with EPS 22°C PCM Payload

38. Temperature Range: Below 37°C EPS Lid Thermos Lid 27°C PCM Vial Holder Thermos Outer shipper with EPS

41. Use of Engineered Phase Change Materials in Cold Chain Packaging Design Presented By: Anthony Alleva Technical Services Manager, TCP Reliable, Inc . Leveraging New Refrigerant Technologies