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CLINICAL
CASE
Lana Mota Chagas
CLINIC
   Female premature newborn (27 weeks) presents:
     Difficulty   in breathing;
     Cyanosis;
     Cough;
     Tachypnea
     Expiratory  grunting
     Nasal flaring


   Diabetic mother.
STUDIES, EXAMINATION AND
EVALUATION:
   O/E:
     Temp.  37.5°C
     BP: 86/58 mmHg
     RF: 60/min (Normal: 30-50/min)
     P: 148/min
     Oxygen levels: around 70%




 Chest X-ray
 CT scan
X-RAY EXAMS




   PATIENT’S X-RAY   NORMAL X-RAY
CT SCANS




   PATIENT’S CT   NORMAL CT
FINDINGS:
 Diffuse granular opacities
 Low lung volumes
DIAGNOSIS:
   SURFACTANT DEFICIENCY DISORDER

     It’sa respiratory disease, common in premature
      newborns
     The primary cause is the inadequacy of the
      surfactant fluid, which coats the internal walls of
      the lungs.
     Ideally, the fetus’s lungs start making the surfactant
      between the 26th and the 34th week; a reason why the
      disorder is more common in premature infants.
     The syndrome is more frequent in infants of diabetic
      mothers.
A BIT OF EMBRYOLOGY…
 While the embryo is inside the uterus, the lungs
  are filled with amniotic fluid. When the newborn
  cries for the first time and the breathing begins,
  most of the fluid is reabsorbed. Once it happens,
  the surfactant liquid remains deposited as a thin
  layer on the alveolar cell membranes.
 When the air gets in, with the first breath, the
  layer of surfactant protects the alveoli of a
  possible collapse.
 When the baby cries, if there is no surfactant
  liquid, or if it’s insufficient, the alveoli may
  collapse.
TREATMENT:
 Surfactant Replacement Therapy: To provide
  surfactant to the infants till they are capable of
  producing their own surfactant. In such
  situations surfactant is directly pushed into the
  baby’s lungs using a breathing tube.
 Breathing Support and Oxygen Therapy: Often
  in infants with surfactant deficiency, oxygen
  therapy is recommended with the intention of
  ensuring adequate oxygenation of the various
  parts of the body and to assure that the
  essentials organs of the body function
  appropriately.
PROGNOSIS:
 The prognosis of this lung disease is variable,
  depending on the severity of the disease.
 But in the case of this patient, the prognosis is
  good and the child can have a normal life.
ANY QUESTIONS?
THANK YOU!!!

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Clinical Case - Suractant Deficiency Disorder

  • 2. CLINIC  Female premature newborn (27 weeks) presents:  Difficulty in breathing;  Cyanosis;  Cough;  Tachypnea  Expiratory grunting  Nasal flaring  Diabetic mother.
  • 3. STUDIES, EXAMINATION AND EVALUATION:  O/E:  Temp. 37.5°C  BP: 86/58 mmHg  RF: 60/min (Normal: 30-50/min)  P: 148/min  Oxygen levels: around 70%  Chest X-ray  CT scan
  • 4. X-RAY EXAMS PATIENT’S X-RAY NORMAL X-RAY
  • 5. CT SCANS PATIENT’S CT NORMAL CT
  • 6. FINDINGS:  Diffuse granular opacities  Low lung volumes
  • 7. DIAGNOSIS:  SURFACTANT DEFICIENCY DISORDER  It’sa respiratory disease, common in premature newborns  The primary cause is the inadequacy of the surfactant fluid, which coats the internal walls of the lungs.  Ideally, the fetus’s lungs start making the surfactant between the 26th and the 34th week; a reason why the disorder is more common in premature infants.  The syndrome is more frequent in infants of diabetic mothers.
  • 8. A BIT OF EMBRYOLOGY…  While the embryo is inside the uterus, the lungs are filled with amniotic fluid. When the newborn cries for the first time and the breathing begins, most of the fluid is reabsorbed. Once it happens, the surfactant liquid remains deposited as a thin layer on the alveolar cell membranes.  When the air gets in, with the first breath, the layer of surfactant protects the alveoli of a possible collapse.  When the baby cries, if there is no surfactant liquid, or if it’s insufficient, the alveoli may collapse.
  • 9. TREATMENT:  Surfactant Replacement Therapy: To provide surfactant to the infants till they are capable of producing their own surfactant. In such situations surfactant is directly pushed into the baby’s lungs using a breathing tube.  Breathing Support and Oxygen Therapy: Often in infants with surfactant deficiency, oxygen therapy is recommended with the intention of ensuring adequate oxygenation of the various parts of the body and to assure that the essentials organs of the body function appropriately.
  • 10. PROGNOSIS:  The prognosis of this lung disease is variable, depending on the severity of the disease.  But in the case of this patient, the prognosis is good and the child can have a normal life.