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Maven and google pharma r&d (1)
1. Cloud-Enabled Pharmaceutical
R&D
October 31, 2014
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information contained in the document if it is obtained from another source without restriction.
2. Shifting Pharmaceutical R&D Operating Models
“Externalization and Virtualization Trends in Pharma and Biotech are Growing at 10-20% per year.
Moreover, R&D Spending is shifting (average 44% spent externally) to external small and mid-size
companies that provide specialized capabilities”
-Michael Elliott, Atrium Research
Externalization =
Virtualization =
Outsourcing Specific R&D Capabilities to
Specialized Contract Research and
Manufacturing Partners; Several Different
Companies in Partner Ecosystem
Outsourcing All R&D Capabilities to Specialized
Contract Research and Manufacturing Partners;
Many Different Companies in Partner Ecosystem
As R&D operating models transition to externalization and virtualization; the
supporting IT infrastructure must move to the cloud to adequately meet the rapidly
evolving needs of the business.
3. R&D IT Challenges
Opportunities and Challenges for the Cloud
Opportunities Presented By The
Cloud
● Biopharma R&D and IT Budget Remains
Flat (2005+)
● Opportunistic and Frequent M&A Create
Data Integration Challenges
● Applications and Data Integrations vary,
further complicated by M&A
● Increase speed of Innovation through
better enabled collaboration
● Data Integration across Ecosystems
through ease of sharing and management
● Lower entry and support costs free up
capital for reinvestment
“Strategies to better inform decision making could generate up to $100 billion in value
annually across the US health-care system, by optimizing innovation, improving the
efficiency of research and clinical trials” – McKinsey
4. External Data
Evolving Operating Models Create Data Challenges
DMPK &
Toxicology
Process
Development
Clinical Trials
Manufacturing
& Distribution
Sales &
Marketing
Post-Market
Reporting
DiscoveryOperating
Model
Internal Data Internal Data Internal Data Internal Data Internal Data
Internal Data
External Data
Internal Data
External Data
Traditional -
“All capabilities
In-house”
Externalization
Virtualization
Internal Data
External Data
Internal Data
External Data
External Data Internal Data
External Data
External Data
Internal Data Internal Data
External Data
Internal Data
External DataExternal Data
External Data
External Data
External Data
External Data
Internal Data
External Data
Internal Data
External DataExternal Data
External Data External Data
External Data
External Data
External Data
External Data External Data
External Data
External Data
External Data
External Data
External Data
External Data
Evolving R&D operating models have a more complicated
partner ecosystem with more external data-sources to be
integrated
Value-Chain
5. Currently, Pharmaceutical R&D Occurs in Data Silos
External Data Sources* Internal Data Sources*
Clinical
Supply-Chain
Partner
Clinical Study
Recruitment
Partner
As a result, it can be extremely challenging to identify patterns across the
drug development value-chain and gain actionable, holistic insights.
Clinical Trial
Management
Partner 1
Clinical Trial
Management
Partner 2
Clinical
Manufacturing
and
Distribution
Process
Development
Discovery
Internal
Clinical Trial
Management
Group
*Example Data Sources
6. Opportunity: Cloud Enables Collaboration in Clinical Trials
External Data Sources Internal Data Sources
Clinical
Supply-Chain
Partner
Clinical Study
Recruitment
Partner
Cloud collaboration capabilities enable more efficient clinical trials:
Ex. Collaboration across partner ecosystem enables more accurate prediction of clinical
drug supply demand to minimize waste and optimize manufacturing
Clinical Trial
Management
Partner 1
Clinical Trial
Management
Partner 2
Clinical
Manufacturing
and
Distribution
Process
Development
Discovery
Internal
Clinical Trial
Management
Group
7. Opportunity: Search Enables FDA Audit Preparation
External Data Sources Internal Data Sources
Analytical
Method
Development
Partner
Drug Product
Development
Partner
API
Development
Partner
CMC
Submission
Partner
QC/QA Analytical Pharmaceutics Process
Development
Cloud Data-Integrity and Search capabilities enable faster audits:
Ex. Elastic search capabilities enable regulatory teams to quickly find, integrate and
search documents and data to more efficiently prepare for audits
8. Opportunity: Data Integration Enables Innovation in Discovery
External Data Sources Internal Data Sources
Library
Development
Partner
HTS Partner
Bioprofiling
Partner
Clinical Trial
Partner Discovery DMPK
Clinical Trial
Management Toxicology
Cloud Data-Integration capabilities enable Innovation:
Ex. Data Integration capabilities enable drug discovery teams to compare large,
disparate data-sets to understand how laboratory discoveries translate to the clinic
(translational informatics)
9. Opportunity: Cloud Enables Large-File Sharing of Microscopy Images
External Data Sources Internal Data Sources
3-D Imaging
Partner
Histology
Partner
Published
Microscopy
Results
Cell-based
Assay Partner Discovery DMPK Toxicology
Cloud Enables Large File-Sharing
Ex. Scientists are able to share and analyze many large-size (GB+) files across partner
ecosystems that were previously unshareable due to file-size limitations.
10. In the Future, Cloud-Enabled Pharmaceutical R&D
Cloud-enabled pharmaceutical R&D will provide accessible data across partner
ecosystems and evolving operational models.
Seamless Drug Development Data Across Partner Ecosystems
DMPK &
Toxicology
Process
Development
Clinical Trials
Manufacturing
& Distribution
Sales &
Marketing
Post-Market
Reporting
DiscoveryValue-Chain
Cloud-based
ELN / LIMS
Cloud-based
ELN/LIMS
Cloud-based
ELN/LIMS/LES
Cloud-based
eTMF
Cloud-based
ERP/MES/SCM
Cloud-Based
CRM/B.I
Cloud-based
Med Comm
Data
Ecosystem
11. Why the Cloud for Pharmaceutical R&D?
+ Frequent; Opportunistic Mergers and Acquisitions
+ Complicated; Quickly Evolving R&D Ecosystems
+ Disparate Data Sources
+ Large Data Volumes
+ Challenges with IT Budget and Resource Allocation
= Major Opportunity for the Cloud
12. ● Data volumes require new technologies
and skillsets
● Need to revisit core IT infrastructure -
cloud-based laboratory informatics tools
should be deployed across partner
ecosystems
● More life science and data science
domain knowledge is required than
traditional pharma IT projects
● Disparate data sources can be difficult to
combine
So Why Isn’t Everyone Already Doing This?
13. For the past 15 years, Google has
been building out the world’s
fastest, most powerful, highest
quality cloud infrastructure on the
planet.Solutions for Life Sciences on the
Google Cloud Platform
14. ● Leverage the same Big Data platform that
Google operates its business on
● Greatly reduce both initial capital &
operating costs
● Reduce technology complexity and risk
● Focus on the analysis rather than on the
infrastructure
● Benefit from continuous innovation
● Reduce dependency on limited IT resources
● Speed-to-value is 1-3 months vs 6+ months
Benefits of the Google Cloud
18. How It Works: Data Integration Enables Innovation in Discovery
19. How It Works: Cloud Enables Sharing of Large Microscopy Images
20. Getting Started
Get started with a 3-4 week pilot,
demonstrating value on 1-2 data
sources.
Automate loads of pilot data
sources and create templates for
future data loads within 6 weeks.
Initiate projects to expand data
sources and scale platform for
increasing volumes.
24. • Flexible and Familiar Infrastructure
• High Data Security
• Connect with the Google Network
• Fast and Easy Provisioning
• Flexible Billing
• Large and Powerful Disks
• Green Computing
• Partner Powered
Value
Compute Engine
25. Features
• Sub-hour Billing
• Up to 10TB Persistent Disk
• Over 44 Instance Types
• Advanced Networking
• Instance Metadata and Startup Scripts
• Load Balancing
• Monitoring
• Snapshotting
Compute Engine
26. • Fully Managed Platform
• Easy Development & Deployment
• Focus On Your Code Not Your Server
• Automatic Scaling
App Engine
Value
30. • Accessible Anywhere
• Secure Sharing
• Same High Replication Datastore Used
By App Engine Apps Today
• Equally Fast Queries For Any Sized Dataset
• Data is Replicated Across Several Data Centers
• Use From Any Application or Language
• Serving 4.5 Trillion Requests Per Month
Cloud Datastore
Value
31. • Auto-scale
• Schemaless Access
• SQL-like Capabilities
• Authentication That Just Works
• Fast and Easy Provisioning
• RESTful Endpoints
• ACID Transactions
• Local Development Tools
• Built-in Redundancy
Cloud Datastore
Features
32. • Fully managed
• Ease of Use
• Highly Reliable
• Flexible Charging
• Security, Availability, Durability
• EU and US Data Centers
• Easy Migration & Data Portability
• Control
Cloud SQL
34. Maven Wave assists clients in creating and capitalizing on change
opportunities through a unique blend of strategic insight, business
knowledge, and technology expertise.
These disciplines are inextricably linked together in successful change
efforts; change drives value, and value is driven by innovation.
Clients increasingly want solutions that are more social, mobile, and
rooted in analytics. To deliver on the promise of the cloud, Maven
Wave fuses traditional consulting discipline with cutting-edge
technology development.
Our solutions capitalize on the evolution of technology trends to foster
innovation to help grow your business into the future.
About Us
Cloud
Mobile
Apps
Data
Design
35. Strategy-Led, Results-Focused Consulting
Cloud • Mobile • Apps • Data • Design
________________________________________________________________________________
#2 on Crain’s Chicago Business Fast Fifty - 2014
101 Best and Brightest Companies to Work For - 2014
Google Enterprise North America Innovation Partner of the Year - 2013
About Us
36. Company History
2008 2009 2010 2011 2012
Triton-Tek Acquired
App Dev, Hosting and Offshore
2013
Biersma Creative
Acquired
Creative design agency
Fin Tech Unit Launched
Major client signed
Maven Wave
Launched
Client #1 signed
Google Unit Launched
Partnership agreement signed
ILM Unit Launched
Strategic partnership
Maven Wave
2014
101 Best Places to Work
Award received
Google North Central Partner of the
Year
Award received
101 Best Places to Work
Award received
Inc 500/5000
#641 on the list
Google Innovation Partner of the Year
Strategic partnership
Crain’s Fast 50
#2 on the list
37. Services
Data management
solutions to take control
over growing data and
storage costs.
Big Data
Globally deliver unique,
innovative cross-device
& platform business
solutions with leading
technologies.
UX design integrating
fluid aesthetics with
functional solutions to
create powerful
engagement.
Identify critical drivers &
align solutions providing
most impactful
performance returns.
Migration, integration
and change
management to
leverage best of SaaS,
PaaS & IaaS.
Technology SolutionsConsulting Cloud
User Experience
& Design
38. Geographic Footprint
West - Business Dev
Los Angeles, CA
Corporate Headquarters
Chicago, IL
Development and QA Center
Chandigarh, India
United States & Canada India
Business Dev, Delivery
Toronto, ON
Midwest - Delivery
St. Louis, MO
39. Management Consulting
Clients
Maven Wave assists clients in creating and capitalizing on
change opportunities through a unique blend of strategic
insight, business knowledge, and technology expertise.
Our approach focuses on identifying the right problems,
sequencing them in a way that yields the highest impact
first, and objectively measuring and managing to
successful outcomes.
● Business Case Development
● Roadmap Development
● Transformation Planning
● Program Management Office
● Business Requirements
● Change Management
● Operational Performance and Process
Engineering
What We Do
Services
40. Technology Solutions
Clients
Maven Wave specializes in solution-based software
development, integration and delivery that can solve your
most complex enterprise problems. Our consultants offer
industry best practices including Agile project execution
that provides working software every two weeks while
leveraging proven development patterns and practices.
● Enterprise Agile Advocacy & Delivery
● Native & Hybrid Mobile Solutions
● Multi-Platform Custom Development
● Data Analytics & Business Intelligence
● Premise & Cloud Centric Solutions
● Application Maintenance / Outsourcing
What We Do
Services Technology
41. User Experience & Design
Maven Wave’s user experience and design expertise
enables us to better deliver social, collaborative and
mobile solutions that translate into intelligent, functional
and brand-conscious experiences on any device.
● User Experience
● Website/Mobile/Application Design
● Responsive Design
● Visual Design
● Brand Design
● Marketing Strategy
What We Do
Services
Clients
42. Google Cloud
Maven Wave is a Google Enterprise Premier Partner,
offering cloud services that span the Google enterprise
portfolio. We combine Google technology, experienced
consultants and a wide range of capabilities to deliver
innovative solutions in the cloud.
● Google Apps Planning, Deployment & Advocacy
● Collaboration Solution Development
● Google Big Data Analytics & Integration
● Enterprise Search Solutions
● Google Maps for Location Based Services*
What We Do
Services
Technology
Clients
43. Google Partnership Highlights
Maven Strategic Drivers
▪ Embrace "Cloud" solutions to drive sustained business value
▪ Synergistic with core consulting business & resources
▪ Transformational not transactional solution focus
▪ Fosters long-term client relationships
▪ Provides exposure to broader services capabilities
Partnership Highlights
▪ Google Premier Partnership across Apps, Platform, Search,
Geo* and Chrome
▪ Exclusive strategic focus on large enterprise customers
▪ Embraced by Google for transformational situations & solutions
▪ Provide NA coverage along with Global solution support
"We are proud to recognize Maven Wave as our 2013 Innovation
Partner of the Year. Maven Wave has consistently demonstrated
sales, deployment and support excellence to our customers
throughout 2013.”
Mark Hodgson
Head of Global Partner Programs at Google
44. Global Delivery Services
Project Manager
Technical Architect
Business Analyst
Technical Architect
Developer
Quality Assurance
Maven Wave Pod System
Well suited to Agile development
▪ Lower leverage ratio reduces risk
▪ Google enables high level of daily, live, interaction
▪ Maximize time zone overlap
Flexible structure reduces cost
▪ Blended on/off shore teams yield cost advantages
▪ Blend can be changed to manage cost
▪ Blended rates can yield flexible scale up/down
48. Life Science - Delivering In a New Ecosystem
SOFTWARE
Package
Custom
Cloud
Legacy
QUALITY
Company
Vendor
Consultancy
Offshore
DELIVERY
Ecosystem of
Talent
Network
Architects &
Craftsmen
49. Healthcare & Life Science - Electronic Lab Notebook
Situation
The Global Pharmaceutical R&D group needed to migrate from a
paper-based lab notebook to an electronic lab notebook (ELN)
system to better support process optimization, knowledge
sharing, intellectual property protection, and innovation.
Results
Maven Wave supplied a cross-functional team of business system
analysts, ELN configurators, and a project manager. The team
successfully deployed ELNs across multiple business units. These
Deployments successfully passed both FDA and EU (German
Authority) audits, an industry first for an ELN in a Life Sciences
Discovery R&D department. Each business unit saw a marked
increase in process throughput, error decreases, and tightly
integrated intellectual property controls.
Company
Formerly a unit of Abbott Laboratories, AbbVie was spun off as a
separate public company in January of 2013 and is a global life
sciences and biotech company with revenue in excess of $18B.
50. Healthcare & Life Sciences - “Closed Loop” Analytics
Situation
The biologics pre-formulation group hypothesized better Design of
Experiment (DoE) could be positively impacted if they had a holistic
view of their work after technology transfer to formulation. Such a
view would require a common data ontology, data integration, and
organizational agreement.
Results
The team quickly recognized that the challenges were not solely
technological, but one of bridging gaps between different business
units. By basing the project on shared, linked business objectives,
development of queries and visualizations across common data-sets
was managed via structured stakeholder management, agile
processes, and iterative development. By the end of the project, a
set of repeatable queries and visualizations were developed that
were valuable across drug product development.
Company
Formerly a unit of Abbott Laboratories, AbbVie was spun off as a
separate public company in January of 2013 and is a global life
sciences and biotech company with revenue in excess of $18B.
51. Healthcare & Life Sciences - Portal and Mobile App
Situation
The Catamaran member portal site and mobile app provided a
robust client implementation offering but was lacking in user
experience. An evaluation of today’s digital trends and an
increased interest in online health offerings led to the need for
a new digital member experience, a conceptual solution design,
and a roadmap for realization.
Results
Maven Wave developed and delivered a new member portal
and mobile application with an enhanced user experience and
design. This improved digital experience increases customer
acquisitions, revenue from existing clients, and cost savings to
serve customers.
Company
Catamaran is a pharmacy benefit management company that
sells services related to pharmacy benefit management and
medical record keeping to businesses in the United States.
52. Healthcare & Life Sciences - New Product Development
Situation
The AMA continuously seeks deeper engagement with its members
to assist them in the practice of medicine. After careful market
research, the AMA decided to release a physician physician portal
called AMAGINE.
Results
Maven Wave engaged with AMA in a number of areas in the product
development process including identification of key functions and
needs for the product, logical product groupings; worked with sales,
marketing, IT, and development to lay out a phased release plan for
the product; designed the roll out planning process to be used by
physicians and staff as the product is integrated into everyday
operations. This product was later sold to AT&T and is now a part of
the AT&T Healthcare Community.
Organization
Since 1847 the American Medical Association (AMA) has had one
mission: to promote the art and science of medicine and the
betterment of public health. Today, the core strategy used to carry
out this mission is our concerted effort to help doctors help
patients.
53. Healthcare & Life Sciences - SW Delivery Optimization
Situation
DestinationRX needed to increase output of new software
functionality to its health insurance clients, but the product
management and product development process was a bottleneck. The
company needed to improve the speed and efficiency of its technology
product development cycle from the identification of customer need
through roll out..
.
Results
Maven Wave completed an end to end analysis of the product
management and software development process and then identified
and implemented opportunities for improved throughput, speed, and
quality.
Company
A leading provider of Internet based tools to the nation’s largest
health insurance providers. DRX’s platform is an online decision tool
used to help consumers make better health care decisions for
themselves and their families.
55. Growing Problem with Big Rewards for Solving
Drivers of Growth
Analytics & intelligence
Big data / real-time processing
Regulatory compliance
Social, email, fileshare, sharepoint growth
Video & large media formats
10 % 13 % 16 % 20 % 25 % 32 %
Storage spend as % of IT budget
Growth rate of data volume: 30 %
Growth rate of TCO data spend: 29 %
TCO Data Spend
Projection
(in $ millions)
3.5 x
x
56. Annual Spend on Storage
● Estimated 69% of data being stored
today is of NO USE to the company
● Every year, the company continues to
spend valuable budget dollars on
storage for this same, growing “debris”
57. Business Units Information
Technology (IT)
Legal Corporate
Records
Enterprise
Benefits
● Manage clear policy for
business utility of all
created data
● Commitment to ILM
program
● Implement integrated
technology solutions in
archival, discovery,
policy syndication, and
disposal
● Enable data source
catalog management
● eDiscovery process
change and integration
● Commitment to ILM
program (e.g. appl
decommission)
● Retention policy
definition and
management
● Process change and
integration
● Commitment to ILM
program
Coordinated
Contribution
● Tremendous cost savings
● Dramatic risk reduction
● Convert maintenance budget into strategic investment
● Performance - rapid innovation and highly responsive operation
Silo efforts by any single
organization provides minimal
benefit Coordinated attack generates amplifier effect
A Coordinated Attack is Required
58. Financial Services ILM
Technology
Landscape
Capabilities
Dedicated resources with many years of
Information Management experience
Management consulting combined with technology
delivery
Established partnerships with leading technology
solutions in this space
Proven implementation methodology with solution
accelerators
Referenced Success
ILM Practice
59. Healthcare & Life Sciences - ILM Strategy, Architecture and Process
Situation
Design and implement ILM policies, processes and solutions that
allows Cambia to defensibly dispose of structured & unstructured
data debris and only retain data that is of business value, on legal
hold or required for compliance with retention policies
Results
Created the integrated ILM solution architecture which included
more than 10 applications and the integrations between them.
Completed data disposal analysis of unstructured data across
Cambia’s email and file share. Configured and deployed the first
application on the roadmap, the Atlas legal hold suite.
Company
Cambia Health Solutions provides a wide range of healthcare
information technology and software development, retail
healthcare, health insurance, life insurance, pharmacy benefit
management, consumer engagement and wellness.
60. Situation
As part of the divestiture from Abbott, AbbVie is creating
enterprise capabilities for structured data disposal and archiving.
The initial phase will target ~50 Finance applications and over 500
Lotus Notes databases.
Results
Gather decommissioning requirements from the business units (e.
g. Finance, Quality, etc.). Develop and execute a process to
decom approximately 50 Phase 1 Finance applications. Develop
and execute a process to archive hundreds of Phase 1 Lotus Notes
databases. Lead cross-functional teams through execution of
archive initiatives.
Company
Formerly a unit of Abbott Laboratories, AbbVie was spun off as a
separate public company in January of 2013 and is a global life
sciences and biotech company with revenue in excess of $18B.
Healthcare & Life Sciences - ILM Strategy, Architecture and Process
61. Situation
Sanofi needed to upgrade its core ILM platform, IBM Atlas
Process Manager, create a QA/Test environment, and then
design, develop and rollout classes to attorneys and paralegals
in both US and in Canada.
Results
Ensured clear business understanding of functional and design
issues. Developed UAT criteria, and templates to capture test
results and then guided customer through acceptance testing
cycles. Authored and delivered full-day and abridged Atlas
courses covering four different roles. Instantiated the Atlas
configuration in production, ensuring as-built environment was
consistent with QA deployment used in user acceptance testing.
Company
Sanofi is an integrated global healthcare leader that discovers,
develops and distributes therapeutic solutions focused on
patients’ needs with over € 32.9 billion in revenue.
Healthcare & Life Sciences - ILM Strategy, Architecture and Process
