When an injury occurs to blood vessels, platelets clump at the wound to plug it. The platelets also release clotting factors that activate the coagulation cascade. This involves thrombin converting fibrinogen into fibrin strands to form a mesh and clot that stops blood loss from the injured vessel. The clotting mechanism helps seal wounds and prevents further blood loss until healing can occur.
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F5 1.3 mechanism of blood clotting
1.
2.
3. Injury in blood vessels
Platelets
Platelets clump at the wound
Release of thrombokinase
Vitamin K
Prothrombin
Thrombokinase
Thrombin
Calcium ions
Fibrinogen
Clot forms to stop further blood loss
4.
5. Describe the blood clotting mechanism
When you get cut, blood vessels around the wound immediately
constrict to reduce blood loss.
The platelets in the blood exposed to air become sticky and clump
together to plug the wound.
___________________& other clotting factors are released by platelets.
In the presence of __________ ions, thrombokinase converts
prothrombin into thrombin. Prothrombin a plasma protein
synthesized in the liver and requires _______________.
Thrombin converts soluble plasma protein, _____________ into
insoluble _________________ which form a meshwork of threads over
the wound.
As the blood flows out, erythrocytes & platelets are trapped in the
fibrin fibres and a blood clot forms. It dries to form ________
When the wound heals, new skin is formed & the scab peels off.