Slides from the FMRIPREP & MRIQC Focus group held Jan 13, 2017 at Stanford University.
MRIQC provides a series of image processing workflows to extract and compute a series of NR (no-reference), IQMs (image quality metrics) to be used in QAPs (quality assessment protocols) for MRI (magnetic resonance imaging). http://mriqc.readthedocs.org
Best Call Girls In Sector 29 Gurgaon❤️8860477959 EscorTs Service In 24/7 Delh...
FMRIPREP & MRIQC Focus: MRIQC
1. Stanford University
Focus group: MRIQC
Quality Control of structural and functional MRI
Oscar Esteban <oesteban@stanford.edu>
Poldrack Lab, Stanford University
January 13th
, 2017
3. Stanford University
2/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
But sometimes, we are way too far from perfection
(MRIQC mosaic, courtesy of Joke Durnez)
10. Stanford University
9/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
Manual assessment on the ABIDE dataset (N=1102)
- Time consuming
- Intra-rater bias
- Inter-rater bias
- Rater 1: 15% reject
11. Stanford University
10/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
Objectives of Quality Control
Exclusion criteria – as objective as possible.
Quality Badge – Deciding on using a public dataset (is it appropriate for my
design/study?)
Diagnosing fixable problems with data acquisition process:
Types of sequences
Scanner malfunctions
Head padding
Participant instructions
12. Stanford University
11/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
Image Quality Metrics (IQMs)
Physical phantoms (Price et al., 1990)
No-reference Image Quality Metrics (IQMs) (Woodard and Carley-Spencer,
2006)
Aim at artifacts and analyze noise distribution (Mortamet et al., 2009)
Combined general volumetric and artifact-targeted IQMs (Pizarro et al., 2016)
13. Stanford University
11/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
Image Quality Metrics (IQMs)
Physical phantoms (Price et al., 1990)
No-reference Image Quality Metrics (IQMs) (Woodard and Carley-Spencer,
2006)
Aim at artifacts and analyze noise distribution (Mortamet et al., 2009)
Combined general volumetric and artifact-targeted IQMs (Pizarro et al., 2016)
14. Stanford University
11/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
Image Quality Metrics (IQMs)
Physical phantoms (Price et al., 1990)
No-reference Image Quality Metrics (IQMs) (Woodard and Carley-Spencer,
2006)
Aim at artifacts and analyze noise distribution (Mortamet et al., 2009)
Combined general volumetric and artifact-targeted IQMs (Pizarro et al., 2016)
15. Stanford University
11/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
Image Quality Metrics (IQMs)
Physical phantoms (Price et al., 1990)
No-reference Image Quality Metrics (IQMs) (Woodard and Carley-Spencer,
2006)
Aim at artifacts and analyze noise distribution (Mortamet et al., 2009)
Combined general volumetric and artifact-targeted IQMs (Pizarro et al., 2016)
16. Stanford University
12/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
IQMs: Structural MRI
Noise measurement
Signal-to-noise ratio (SNR) - higher is better
Contrast-to-noise ration (CNR) - higher is better
Sharpness (full-width half maximum estimations) - smaller FWHM is
better
Goodness of fit of a noise model into the noise in the background (QI2) -
lower is better (Mortamet et al., 2009)
Coefficient of Joint Variation (CJV) - lower is better
Information theory
Foreground-Background Energy Ratio (FBER) - higher is better
Entropy Focus Criterion (EFC) - lower is better
Artifacts
Segmentation using mathematical morphology (QI1) - lower is better
Measurements on the estimated INU (intensity non-uniformity) - values
around 1.0
Partial Volume Errors (PVE) - lower is better
Other: summary statistics, intracranial volume fractions (ICV)
17. Stanford University
13/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
IQMs: Functional MRI
Noise measurement: SNR, tSNR, temporal standard deviation
Information theory: EFC, FBER
Confounds and artifacts:
Framewise Displacement (FD) - lower is better
(Standardized) DVARS (D referring to temporal derivative of timecourses,
VARS referring to RMS variance over voxels) - lower is better
Ghost-to-Signal ratio (GSR) - lower is better
Global correlation (GCOR) - lower is better
Spikes (high frequency and global intensity)
AFNI’s outlier detection and quality indexes
18. Stanford University
14/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
Design of MRIQC
Inputs: BIDS (Gorgolewski et al.,
2016b)
Command-line interface: BIDS-Apps
(Gorgolewski et al., 2016a)
The simplest possible pipeline
The fastest possible pipeline
Robust: works on all data
19. Stanford University
15/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
MRIQC Features
What can be expected from MRIQC:
A table of IQMs per subject
The group visual report
An individual visual report per subject
A first-round exercise for the data
What is not expected from MRIQC:
The triage of participants (WIP)
The derivatives of processing
Non-standard morphologies: developing brains, pathology, etc.
20. Stanford University
15/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
MRIQC Features
What can be expected from MRIQC:
A table of IQMs per subject
The group visual report
An individual visual report per subject
A first-round exercise for the data
What is not expected from MRIQC:
The triage of participants (WIP)
The derivatives of processing
Non-standard morphologies: developing brains, pathology, etc.
30. Stanford University
25/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
Questions TBD in the focus group
Are there any additional quality metrics that you would like to be added?
Are there any additional plots that you would like to be added?
Would you like to have diffusion MRI IQMs and reports?
Would you like to participate in manual triage/rating sessions of s/f/d MRI?
33. Stanford University
28/28
Introduction MRIQC Visual reports Running MRIQC Questions References References
References I
Gorgolewski, Krzysztof J. et al. (2016a). “BIDS Apps: Improving ease of use, accessibility and reproducibility of neuroimaging data analysis methods”. en. In: bioRxiv, p. 079145. DOI:
10.1101/079145. URL: http://biorxiv.org/content/early/2016/10/05/079145.
Gorgolewski, Krzysztof J. et al. (2016b). “The brain imaging data structure, a format for organizing and describing outputs of neuroimaging experiments”. In: Scientific Data 3, p. 160044.
ISSN: 2052-4463. DOI: 10.1038/sdata.2016.44. URL: http://www.nature.com/articles/sdata201644.
Mortamet, BÃľnÃľdicte et al. (2009). “Automatic quality assessment in structural brain magnetic resonance imaging”. en. In: Magnetic Resonance in Medicine 62.2, pp. 365–372. ISSN:
1522-2594. DOI: 10.1002/mrm.21992. URL: http://onlinelibrary.wiley.com/doi/10.1002/mrm.21992/abstract.
Pizarro, Ricardo A. et al. (2016). “Automated Quality Assessment of Structural Magnetic Resonance Brain Images Based on a Supervised Machine Learning Algorithm”. English. In:
Frontiers in Neuroinformatics 10. ISSN: 1662-5196. DOI: 10.3389/fninf.2016.00052. URL:
http://journal.frontiersin.org/article/10.3389/fninf.2016.00052/abstract.
Price, Ronald R. et al. (1990). “Quality assurance methods and phantoms for magnetic resonance imaging: Report of AAPM nuclear magnetic resonance Task Group No. 1”. In: Medical
Physics 17.2, pp. 287–295. ISSN: 0094-2405. DOI: 10.1118/1.596566. URL:
http://scitation.aip.org/content/aapm/journal/medphys/17/2/10.1118/1.596566.
Woodard, Jeffrey P. and Monica P. Carley-Spencer (2006). “No-Reference image quality metrics for structural MRI”. en. In: Neuroinformatics 4.3, pp. 243–262. ISSN: 1539-2791, 1559-0089.
DOI: 10.1385/NI:4:3:243. URL: http://link.springer.com/article/10.1385/NI:4:3:243.