Jacob Eva - 3D Printing in the Medical Industry

1. Jacob Eva
Operations Manager

2. 3D PRINTING IN THE MEDICAL FIELD
A COMPREHENSIVE LOOK AT ADDITIVE MANUFACTURING’S CONTRIBUTION TO
• Personal Introduction and Background
• Overview of Custom Orthopaedic Solutions and its mission
• Additive manufacturing applications in medicine
• What to look for in 3D printing technologies
• Future of additive manufacturing in medicine
• Q&A

3. BACKGROUND
• Graduated Ohio Northern University 2002
• Advanced Manufacturing and Virtual Simulation
• 14 years in 3D printing
• 12 years in service bureau industry
• Worked at companies in Ohio, California and Oklahoma.
• First exposed to medical printing in 2004
• Joined Custom Orthopaedic Solutions February 2014

4. FIRST EXPOSURE TO MEDICAL PRINTING
• 2004, created cranial facial implants.
• CAD models from CT Scan
• Generated on SGI O2 computer.
• 3D printed skull model as template
• Implant mocked up and cast in PMMA
• $300 on Ebay

5. CUSTOM ORTHOPAEDIC SOLUTIONS
• Specialize in preoperative planning solutions for orthopedic surgeons.
• Company formed in 2011, result of Ohio Third Frontier
• First product launch in 2015 for shoulder arthroplasty
• Use a combination of software and 3D printing to plan implant placement and achieve
planned trajectory
• Proper implant placement can lend itself to optimal range of motion, improved implant
life, and secure anchoring of implant
• Shoulder software and web portal being used by physicians in ongoing
shoulder studies
• Currently being distributed by Arthrex

6. 3D SMARTBONE
• Generated from patient CT
scan
• Landmark coordinate system
established
• Implant trajectory established
by technician and approved
by physician
• 3D Smartbone assembled
from approved trajectory

7. SCAPULA COORDINATE SYSTEM
(FRIEDMAN’S LINE)

8. COS WEB PORTAL
• Preoperative plan uploaded to
web portal for physician
approval
• Physician can make
adjustments and change
implant size/type.
• Approved plan received into
COS software for SmartBone
assembly.

9. 3D PRINTED
SMARTBONE
INTELLIGENT REUSABLE
INSTRUMENT (IRI)
CAPTURING FORM OF
SMARTBONE
IRI TRANSFERRED TO
PATIENT, SMARTBONE PIN
TRAJECTORY DUPLICATED
INTELLIGENT REUSABLE INSTRUMENT (IRI) USED IN SURGERY

10. 5D SMARTBASE DEVELOPED AS AN
ALTERNATIVE TO 3D PRINTED
SMARTBONE.
DEVELOPMENT OF 5D SMARTBASE

11. A.M. APPLICATIONS IN MEDICINE
PUBLIC PERCEPTION
• “Like in Grey’s Anatomy?”
• Many examples featured on the show
were based on real life cases

12. A.M. APPLICATIONS IN MEDICINE
• 54 year old man with tumors invading the
sternum and ribs
• Removal of the tumors would leave
unprotected heart and lungs
• Solution: custom 3D printed stainless steel
replacement sternum and ribs
• Designed and printed in Melbourne, Australia
• Surgery performed in Spain
• Patient discharged 12 days after surgery

13. A.M. APPLICATIONS IN MEDICINE
3 AREAS WHERE A.M. HAS CONTRIBUTED
• Medical Models
• 3D representations of patient specific anatomy
• Used in surgical planning and research
• Prosthetics
• Low cost custom sized components
• Flexibility in design and creativity
• Implants
• Patient specific for custom fit
• Ability to treat conditions not supported by available implants

14. A.M. APPLICATIONS IN MEDICINE
Custom Prosthetic Limb Medical Model of Human Heart

15. WHAT TO LOOK FOR IN 3D PRINTING TECHNOLOGIES
• Materials – How does it need to perform?
• Heat Deflection
• Rigidity
• Surface finish
• Aesthetics
• Chemical resistance
• Biocompatibility
APPLICATION IS EVERYTHING

16. WHAT TO LOOK FOR IN 3D PRINTING TECHNOLOGIES
• Build Process – What techniques will achieve desired result?
• Build resolution
• Surface finish
• Multiple materials
• Post processing procedures
• Support removal
• Part smoothing
APPLICATION IS EVERYTHING

17. WHAT TO LOOK FOR IN 3D PRINTING TECHNOLOGIES
• Cost of Ownership – How much?
• Capitol Expense
• Material Costs
• Ongoing Maintenance
• On-sight expertise and labor
APPLICATION IS EVERYTHING
MakerBot Replicator
$1800 on Amazon

18. FUTURE OF A.M. IN MEDICINE
• 3D printed biologics
• Implantable tissues and organs with decreased risk of rejection.
• 60% of solid organ transplants in 2012 were kidneys
• Currently over 100,000 people awaiting kidney transplants www.kidney.org
• Absorbable 3D printed scaffolding for use in tissue repair and bone
growth
• 3D printed pharmaceuticals
• Low volume production runs and personalized medicine
• Produce a wide range of APIs (Active Pharmaceutical Ingredients) on
demand for use in medicine R&D.

19. Q&A?
• Will hospitals and physicians 3D print their own solutions for
patient care?
• Unlikely given current regulatory guidelines
FDA Guidance on 3D printed medical Devices
http://www.fda.gov/downloads/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/UCM499809.pdf

20. Q&A?
Jacob Eva
Custom Orthopaedic Solutions
7100 Euclid Ave. Unit 180
Cleveland, OH 44103
jeva@customorthopaedics.com