it is talking about filariasis ,causes,symptoms,signs,diagnosis , treatment and prevention.

1. Filariasis
.

2. Disease
Bancroftian filariasis .
worm
Wuchereria bancrofti.
Brugia malayi.
Loiasis.
Loa loa
Onchocercosis.
Onchocercus volvulus.
Mansonellasis.
Mansonella perstans.
Mansonella ozzardi.

4. tropical regions.
far east
Egypt :
Rasheed, Kerdasa,
Sharkia, Menoufiya
Ashmoon ,menoof

5. Habitat:
lymph nodes and lymph Vessels of
Lower limb , external genitalia , trunk . •
DH:
Man •
IM:
Culex pipiens ,Ades ,anopheles

6. Aedes
Culex pipiens
Anopheles

7. Brugia malayi
Far east ; Malaysia,
India , china.

8. Habitat;
Lymphatic tissue of upper limb
and mamary glands.
IH:
Mansonia , Aedes.
RH;
Monkeys ,cats.

10. Def: 
Pathological lesions occur
in the lymphatic system , due
to the presence of adult
worms(living or dead) but not
due to microfilariae.
symptoms start
3_12months after
infection .
•

11. phases
Asymptomatic
Acute
inflammatory
Tropical
pulmonary
eosinophilia
Obestructive

13. Symptoms;
Systemic ;
Fever
Headache
Local lymphangitis. (affected lymph vessels
of leg are( raised ,red , swollen tender streaks.)
Lymphadenitis.
(legs , epi didymis, tests , scrotaum,
Spermatic cord , vulva )

16. Chylo thorax
Chylous ascitis
Chyluria

17. > Results of complex immune
responses(5_10 years)

1. Thickening of affected part.
2. Hard ,dense , non piting and
non elastic skin.
3. Folded,fissured skin
bacterial infection.
4.No microfilaria in blood.
2ry

18. Diagnosis;
*Clinical.
*Laboratory.
1- Blood examination;
- Wet mount preparation.
-stained thick and thin
blood film
microfilaria


19. _Concentration techniques:

-Modifiedknott”s method.
-Pandit s test
-Diethylcarbamazine provocative test.

20. 2-Urine examination; 
urine sample of chyluria+ 2ml ether
>>>centrifugation and examination
under microscope.

3-X rays for calcified adult.
4-Aspiration of lymphnodes.
5-Immunodiagnosis;(ELISA,IFAT,CFT,IHAT)
detecting antibodies using Dirofilaria immitis
antigen.
6-PCR.
7-Eosinophilia(6-26%).
Filaria of dog

21. Loa loa
Cameroon

22. Habitat:
cojunctiva , eyelid ,loose
subcutaneous tissue.
IH:
Chrysops fly ( golden eye fly)
RH;
Monkeys , rodents.

23. Life cycle

24. Loiasis;
- Irritation and itching in cornea.
- localized calabar swelling;
1- allergic reaction.
2-appears rapidly for 2-3 days then disappear.
3-Hen. egg(Hard, painful, non piting)
-Encephalitis.
- Arthritis.

25. Diagnosis;
clinical;
1-Observation of adult worm under
conjunctiva or over the nose bridge .
2-History of calaber swelling.
Laboratory ;
1-Demonstration of microfilaria in blood at
day time.
2-Serological tests.
3-Esinophilia.

26. Onchocerus volvulus 
Tropical Africa ,Sudan , Yemen,
Saudi arabia , central America

27. Habitat
-Subcutaneous tissue over bony brominances.
-the dermis, subcutaneous nodules ,all chamber of
the eye and they are non periodic
DH;
Man.
IH;
Black flies ,simulium
.

28. Cutaneous lesions

-Onchocerca nodules.
- severe dermatitis and
intense itching over
nodules.
- enlarged lymph node in
femoral triangle .
Eye lesions;
-River blindness •
-Keratitis •
-Iridocyclitis •
-Blindness •
-Degeerative changes
-optic neuritis
•

29. Diagnosis;
Clinical.
Laboratory;
1- Direct;
-Microfilaria in ;1-nodules. 2-eye chambers.
3- cornea.
-Histopathological examination.
-Mazzotti test.
2- Indirect;
-Esinophelia20%.
-PCR, serological test.
-Intra dermal test ( DIROFILARIA antigen).

30. Mansonella Perstans
Mansonella ozzardi
Def;
human filarial nematode,
transmitted by tiny blood
sucking flies called midges.
Disease; Mansonelliasis.
serous cavity filariasis.
-asymptomatic.
- angioedema.
- pruritus, Eosinophilia
- fever.
-headaches.
-arthralgias.
-neurologic manifestation.
- -- Central America, caribbean -

31. Diagnosis;
-Examination of blood samples for identification of
microfilariae of M. perstans, and M. ozzardi based
This diagnosis can be made on the basis of the
morphology of the nuclei distribution in the tails of the
microfilariae
Mansonella perstans

33. 1. Di-ethyl-carbamazine citrate; drug of choice.
2mg/kg daily for 2-3 weeks.
2. Iver mectin; 200-300 ug/kg as single dose
repeated after 2 months for4years.


34. 3.Neostibosan; 0.14gm/kg for 5-7 weeks.
4.General treatment;
Pressure bandage
Anti biotics
5. Surgical treatment.

37. Thank you
Have a nice
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