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In this presentation I've tried to summarize classification of hemolytic anemia and in depth review of rbc membrane disorders like hereditary spherocytosis, hereditary elliptocytosis, enzymopathies of hemolytic anemia like g6pd disorder, pyruvate kinase disorders, hemoglobinopathies related to hemolytic anemia like thalassemia, sickle cell anemia and especially pathophysiology and mechanism of hemolysis either extravascular or intravascular. Hope it helps you understand the entity better.
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Challenges in interpreting serum protein electrophoresis. Requires an approach to recognize pattern within the various protein fractions & differentiate systemic inflammatory response from abnormal antibody production due to neoplastic disorders.Presence of M-band does not always correlate with plasma cell disorders but can be seen some lymphomas, chronic leukaemias, systemic amyloidosis hence need further ancillary tests for diagnosis of aetiology for the M-band.
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Germinal period – 1st – 3rd week Cleavage, formation of Morula, Blastocyst & its Implantation. Differentiation of Trophoblast & Chorion, Appearance of Bilaminar & Trilaminar germ disc, 2 cell stage – app 30 hrs after fertilization., 4 cell stage – app 40-50 hrs after fertilization , 12 cell stage – app 72 hrs after fertilization , ,16 cell stage – app 96 hrs after fertilization
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1.
Sickle cell anemia
Hemolytic anemia
2.
3.
4.
5.
Frontal Bossing X-ray:
‘Hair-on-end’ skull Chronic leg ulcer
6.
7.
8.
2. Hb electrophoresis
– Identification & quantification of HbS (80% Hbs, absence of HbA; HbF & HbA 2 variably increased)
9.
10.
11.
12.
An enlarged spleen
due to splenic sequestration crisis in a patient with sickle anemia
13.
Sickle cells are
seen in splenic red pulp in a case of splenic sequestration crisis.
14.
Kidney: Hemosidrin deposit
LIVER: HEMOSIDEROSIS Hemosiderin deposits
15.
Alloimmune/ Isoimmune: 1)
Hemolytic Transfusion Reaction 2) Hemolytic Disease of the Newborn Hemolytic anemia RBCs are lysed as a result of the action of antibodies of another individual
16.
17.
18.
Hemostatic disorders
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
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