Prognostic Role Of Aa Do2 In Acute Pulmonary Embolism

Prognostic Role of Alveolar-arterial Oxygen Pressure Difference (AaDO2) in Acute Pulmonary Embolism Hsu Jen Te

Introduction ,[object Object],[object Object]

ICOPER: Mortality 11.4% at 2week & 17.4 at 3 months

Acute Pulmonary Embolism ,[object Object],[object Object],[object Object]

Four processes cause arterial hypoxaemia due to inefficient pulmonary gas exchange : ,[object Object],[object Object],[object Object],[object Object]

ABG analysis have proved disappointing as diagnostic modalities ,[object Object],[object Object],[object Object]

Paper reviews ,[object Object],[object Object]

Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) study ,[object Object],[object Object],[object Object]

Our interests ,[object Object]

Methods and Materials CMRGP 650031

Including criteria ,[object Object],[object Object],[object Object]

Excluding criteria ,[object Object],[object Object],[object Object],[object Object]

Treatment ,[object Object],[object Object],[object Object]

Clinical features and biochemical data ,[object Object],[object Object],[object Object]

Artery blood gas analysis ,[object Object],[object Object],[object Object],[object Object]

The arterial/Alveolar oxygen tension ratio(a/APO2 : an index of gas exchange applicable to varying inspired oxygen concentrations) Gilbert and Karetzky et al. American review of respiratory disease 1974

Stability of the arterial/alveolar oxygen partial pressure ratio: effects of low ventilation/perfusion regions. Gilbert el al. Critical care medicine 1979

Clinical Endpoints ,[object Object],[object Object],[object Object]

Statistical analysis ,[object Object],[object Object],[object Object],[object Object]

Results ,[object Object],[object Object],[object Object]

Table 1. Clinical characteristics, echocardiographic parameters, and cardiac troponin I in PE survivors and patients who died at 30 days.

Table 2. Clinical characteristics, echocardiographic parameters, and cardiac troponin I in the 30-day composite-event free group vs. the 30-day composite event group

30-day mortality & composite event rate ,[object Object],[object Object]

Parameters influences primary end point ,[object Object],[object Object],[object Object],[object Object],[object Object]

Additive parameters influences secondary end point ,[object Object],[object Object],[object Object],[object Object],[object Object]

The analytical findings have not been published ,[object Object]

Incidence of thrombocytopenia ,[object Object],[object Object]

Figure 1. ROC curves for variable artery blood gas analysis.

Figure 2. ROC curves for AaDO2 and a/APO2-R ,[object Object],[object Object],[object Object]

The optimal cut-off value for AaDO2 was 53mmHg. ,[object Object],[object Object],[object Object]

A prognostic cut-off value of a/APO2 ratio was 0.49 ,[object Object]

Figure 3. Survival curves at 1 year, based on a cut-off values of AaDO2≥53mmHg vs. AaDO2<53mmHg ,[object Object],[object Object]

Figure 4. Composite event-free survival curves at 1 year, based on cut-off values of AaDO2≥53mmHg vs. AaDO2<53mmHg ,[object Object],[object Object]

What is the role of AaDO2 analysis in patients with documented pulmonary embolism? ,[object Object],[object Object],[object Object]

AaDO2≧53mmHg ,[object Object],[object Object],[object Object]

Future investigation plan ,[object Object]

The role of a/APO2 analysis in patients with documented pulmonary embolism. ,[object Object],[object Object],[object Object]

In the real word, blood gas analysis could be checked under variable FIO2 ,[object Object],[object Object]

a prognostic cut-off value of a/APO2 ratio was 0.49 ,[object Object],[object Object],[object Object]

There was conflicting result about hypoxemia. ,[object Object],[object Object],[object Object],[object Object]

The mechanism for widening AaDO2 and hypoxemia . ,[object Object],[object Object],[object Object],[object Object]

Thrombocytopenia has a significant role in acute pulmonary embolism . ,[object Object],[object Object],[object Object]

Study limitation ,[object Object],[object Object],[object Object]

Conclusion ,[object Object],[object Object],[object Object]

Conclusion 2 ,[object Object],[object Object]

一個不經意的小發現，卻帶給我們喜悅的心情

Prognostic Role Of Aa Do2 In Acute Pulmonary Embolism

Recomendados

Recomendados

Más contenido relacionado

La actualidad más candente

La actualidad más candente (20)

Destacado

Destacado (20)

Similar a Prognostic Role Of Aa Do2 In Acute Pulmonary Embolism

Similar a Prognostic Role Of Aa Do2 In Acute Pulmonary Embolism (20)

Más de Dang Thanh Tuan

Más de Dang Thanh Tuan (20)

Último

Último (20)

Prognostic Role Of Aa Do2 In Acute Pulmonary Embolism