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Dermatology 5th year, 2nd lecture (Dr. Kazhan)
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2. These are group of different skin diseases, which are due to abnormality in keratinization. Disorder of keratinization is due to a defect in keratin metabolism. In the normal epidermis, as the keratinocytes move from the basal-cell layer to the surface, the process of terminal differentiation and cornification involves complex metabolic changes . Different syndromes, which are related to abnormal keratinization, include :
12. Histopathology Hyperkeratosis Hyper grannulosis Prominent rete ridges Mild perivascular infiltrate in the upper dermis and mitosis. Treatment Emolients Improvement may be achieved by 0.1 percent Vitamin A.
13. ICTHYOSIFORM ERYTHRODERMA (Collodion baby) This is a rare severe type of icthyosis present at birth of unknown etiology and has a high mortality rate. It is believed that lamellar exfoliation of the newborn (collodion baby) is a form of lamellar icthyosis Clinical Features Skin manifestations Infants may be born with a distinctive, tough, inelastic collodion-like membrane covering their bodies. The constricting membrane produces a peculiar position of immobility of the limbs and causes ectropion of the eyelids.