1. Clinical and Translational Science Award University of Colorado Ronald J. Sokol, MD Program Director CU Program for Clinical and Translational Sciences April, 2007

7. Basic Research Clinical Investigation Clinical Trials Practice In the Community T1 Bench Bedside Trench Bidirectional Translational Research Molecules & Cells Patients Community & Population T2

9. NIH CTSA Awards: A Home for Clinical and Translational Science Trial Design Advanced Degree-Granting Programs Participant & Community Involvement Regulatory Support Biostatistics Clinical Resources Biomedical Informatics Clinical Research Ethics CTSA HOME Industry Other Institutions

17. Roadmap Funding (dollars in millions) Roadmap Initiative ~ 1% of NIH budget Totals on table may not add due to rounding 9/27/2005 2,179 507 520 448 333 239 132 Total 835 227 214 174 120 61 39 Clinical Research 396 93 96 92 44 43 28 Research Teams 948 188 209 182 169 135 65 Pathways to Discovery Total FY09 FY08 FY07 FY06 FY05 FY04

18. Roadmap Funding (dollars in millions) Roadmap Initiative ~ 1% of NIH budget Totals on table may not add due to rounding 9/27/2005 2,179 507 520 448 333 239 132 Total 835 227 214 174 120 61 39 Clinical Research 396 93 96 92 44 43 28 Research Teams 948 188 209 182 169 135 65 Pathways to Discovery Total FY09 FY08 FY07 FY06 FY05 FY04

26. Research training and education John Steiner Discovery Translation Robert Eckel Community Translation Andrew Kramer Methods Development And Biotechnology Mark Geraci Child and Maternal Health Research William Hay K30 MPH K12 T32 PhDs Adult and Pediatric GCRCs and satellites CTO CPC Drug Discovery Public Health Care Delivery Research networks Implementation Community engagement Methods development Pilot projects Technology Cores Integrating Research programs Biostatistics Informatics Regulatory Ethics CTSI or C Program Directors Board of Governors Evaluation