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1410 prof james raftery nhc2015
1. ‘Is cancer different? Costs, benefits
and who pays?
James Raftery,
Professor Health Technology
Assessment, University of Southampton
2.
3.
4.
5. Themes
• “onco-exceptionalism” - only if more cost
effective?
• Cancer screening
• Cancer drugs
• NICE and cancer drugs
• The oppportunity costs of exceptionalism
• Ways forward
6. Ireland’s 3 cancer screening
programmes
• Breast Screening Programme free (mammograms) women aged
50 to 64 every 2 years. Aim to include up 69.
• Cervical Screening Programme aged 25 to 60 on 1 September 2008.
free smear tests every three years to women aged 25 to 44.
Following two consecutive ‘no abnormality detected’ results,
women aged 45 to 60 are screened every five years.
• The National Bowel Screening Programme. offers free bowel
screening to men and women aged 60-69.Aim 55-74. 2 yearly
• + “opportunistic” prostate cancer screening
7. Broadly as England…..
• But Breast: more restricted age range, Cervical post 44,
Colorectal phasing different
• Prostate cancer screening: US, UK decided against
formal screening programme
• But PSA testing common, especially Ireland
• “Screening is highest in those with highest
socioeconomic status and educational attainment, and
who also hold private insurance cover.”
8. Harms from cancer screening
• All screening imposes harms and benefits
• Inconvenience, False +, overtreatment, worry
• Overtreatment –treat “indolent” cancers
• Most serious with breast screening due to
surgery/mastectomy……less so with lesions in colorectal & cervical?
• UK 2012 review pro on balance
• But Norway study (in press) shows longer terms harms re worry and
employement
• Irish study shows financial harms
12. Conclusions to study comparing Ireland
and N. Ireland
“Prostate cancer Incidence was consistently higher in the RoI than NI
The difference in incidence mainly due to the relative intensity of cancer
investigation via prostatic biopsy, rather than PSA testing
1994-2000, PSA rates similar, but incidence higher in the RoI
PSA testing was increasingly used in NI before 1999, but no rise in incidence until
1999
very low biopsy rate in NI in 1999; incidence rose as biopsy rate rose
higher biopsy rate in the RoI – and higher incidence
in RoI, age-specific trends in incidence mirror those for biopsies
evidence that threshold for biopsy lower in RoI
o lower median PSA level in those with cancer
o studies among primary care physicians (Connolly, 2007 MD thesis;
Drummond et al. BMC Fam Pract 2009) and urologists are consistent with this
o consistent with differences in healthcare system”
13. Cancer drugs- modest gains, high
prices
• All new solid tumor drugs 2002-
14 approved in the USA: median gain in the
progression free period 2.5 months, median
gain of 2.1 months extra life (Fojo et al 2014)
• $500,000 for a year of life in good health gai
ned
• 12/13 new cancer drugs approved in US in 2012
>$100k
14.
15. “But it costs $2.6b to bring pill to
market….”
• Standard pharma case for high prices
• Tufts study puts cost at $2.6b ….not believable (Light)
• But half due to cost of capital at 10% (!!)
• Truth is firms charge what the US market will bear
• Some signs of rebellion due in part to co-payments and
contracting out
• But
16.
17. NICE and cancer drugs
• NICE refuses few drugs wholly (16%) or in part
• But problems with cancer drugs led to 2 changes:
End of Life criteria and Cancer Drugs Fund
• End of Life criteria: doubled the cost/QALy
threshold
• CDF: funds cancer drugs refused by NICE.
Reduced the NICE refusal rate to 7%
18. 2014 Cancer Drugs Fund
• Funding increased to £280 per year to 2016
• “CDF’s panel of experts re-evaluate a number of drugs
currently on the list”,
• incentivise responsible pricing by drug companies.
• We want to create a sustainable Cancer Drugs Fund”
• to develop options for ensuring greater alignment between
CDF and NICE assessment processes.
• The CDF panel will also develop options for a new
“Evaluation through Commissioning” scheme.
19. Drugs at “End of Life”
• NICE 2009 provisional No to four drugs—bevacizumab, sorafenib, sunitinib, and
temsirolimus—for advanced/metastatic renal cell cancer
• NICE was required by government to issue new criteria for drugs at the “end of
life”, defined as
• Life expectancy less than 24 months,
• Gain from treatment of at least 3 months,
• Small patient population, and
• No alternative treatment with comparable benefit available through the NHS.
• NICE said yes to Sunitinib at cost/QALY $100k or double nornal
• By 2012, 14 drugs met the criteria, 9 were approved, costing the NHS £650m pa.
(Latimer BMJ)
20. Opportunity cost of exceptionalism
• If health budget is fixed, then spend more on X (cancer)
means spend less on Y (the rest)
• Difficulty is those denied other treatments are anonymous
• Identify/defend those denied cost effective treatments
• IN NHS, elective surgery for hips, knees, varicose veins,
hernia surgery: £/QALY<£10k
• Best estimates put NHS £/QALY <£15k.
• If so NICE doing harm with threshold £30k/QALY
21. Ireland’s health system
• Mix of public (78%) and high (22%) private
• Strong role of private providers, voluntary
hospitals.
• No/weak NHS ethos
• Move to social insurance: cost $3k/person 2012
• Debate on future of Irish healthcare should face
how much to spend including on cancer.
22. What to do?
• Ongoing challenge, with prices depending mainly on US market
• which is 50% of global market, least regulated
• “if you want to learn about improving healthcare, don’t start here”
(U Reinhardt)
• Irish health system: more Boston than Birmingham (or Berlin)
• All systems struggle to feature opportunity costs
• One option: set cancer budget? Trade off chemo, radiation therapy,
palliative care, screening
23.
24.
25. References
• 1.Burns R Walsh B, Sharp L O’Neil C Prostate cancer
screening practices in the Republic of Ireland: the
determinants of uptake Health Serv Res Policy October
2012 vol. 17 no. 4 206-21 doi:
10.1258/jhsrp.2012.011105 J 1
• Light D, Warburton R Demythologising the high costs of
pharma research BioSocieties (2011) 6, 34–50.
doi:10.1057/biosoc.2010.40; published online 7
February 2011