1. Melanoma Therapy is like a combination Lock.
Melanoma Therapy is like a combination Lock. You need three drugs, they must be in the
right sequence to open the door to your immune system
1). Chemo/Radiation to shed dead tumor cells to be taken up by Dentritic Cells (DCs) as
antigen presenting Cells (APCs)
2).Anti-CTLA-4/AntiPD-1 Blockade to keep the activation on and suppress the Tregs
cells function.
3). Interluekin-2 for the activation, maintain their cytotoxic function, and their survival
The end result, the unleashing of the host’s Immune system on the cancer at large.