SlideShare una empresa de Scribd logo
1 de 26
“NANOMEDICINA. La Última Frontera”




                           Chemistry: Contributions to
                                Clinical Therapeutics
                                      Jaume Veciana
                                      vecianaj@icmab.es




                 www.expoquimia.com
Nanomedicine
             20th Century
 Research based on the discovery of new
         molecular entities (APIs)




 Analgesics         Antibiotics      Cancer treatment


Keys: chemical synthesis, molecular and bioactivity
                 characterization
Nanomedicine
     Drug therapies based in targeted/controlled
               drug delivery systems
              Drug
         (therapeutic action)
                                      Polymeric capsule
                                  (pharmacological features)

Nanocarrier




                  Drug Delivery System



   Increasing the therapeutic efficiency of drugs….
Nanomedicine

  Ideal Nanocarriers as Drug Delivery Systems (DDS)
                 Multifunctional nanobjects
                                 Components                   Functions



                                                              Container

                                                              Protector

                                                              Targeting

                                 Magnetic particle             Diagnosis

                                  Drug                        Therapy

Preparation of drug delivery systems at the nanoscale with scale-up
                              methods
                               P. Couvreur et al., Pharm. Res., 2006, 23, 1417-1450.
Nanomedicine

            Novel Drug Delivery Systems

  Nanoparticles     Polymeric-drug         Vescicles
Nanosuspensions       conjugates          Liposomes
New Methods to Prepare Particulate Drug Delivery Systems

      Using compressed CO2 as a green solvent


                                    Non-toxic

                                    Non-flammable

                                    Cheap

                                    Easy separated from products

                                    Enabling to control particles

                                    Scale-up methods


        J.J. Watkins et al., Science 2004, J.D. Holmes et al. Chem. Eur. J. 2003
New Methods to Prepare Particulate Drug Delivery Systems

      Using compressed CO2 as a green solvent


                                            Vescicles
                                           Liposomes



                                         Polymeric-drug
                                           conjugates


                                          Nanoparticles
                                        Nanosuspensions


               DELOS-family processes
Processing of a drug for bronquial asthma

 Salmenterol xinafoate (SX)                          Drug for inhalatory asthma treatment
             OH

                  NH2+
HO


     HO                  O

                                  OH

                                               CO2
                                               -




          Bioavailable
                                         12                                      Non-bioavailable
                              % Volume




                                         8

                                         4

                                         0
                                              0.1       1           10     100
                                                      Particle Size (µm)
Processing of an antibiotic for resistent infections
Gentamicine loaded in bioadhesive nanostructured polymer as
                       microparticles




                                                       2,5 µm




                                                    Oral Delivery

E. Elizondo et al, Pharm. Res., 2011, 28, 309-321
Integration of Bioactive Principles into Nanovesicles

                                   Integration on surface &
                                  inside of the nanovesicles




                     Compressed
                        CO2




       Integration                  Encapsulation
Integration of Bioactive Principles into Nanovesicles




                                   Cholesterol          CTAB

                     CO2




                                               small molecules
                                     Bioactive macromolecules
Spin-off at PRUAB:
Scaling-up the DELOS methodology

6 mL system          300 mL system             2000 mL system




 25mL                   1250mL                     8300mL
              X 50                   X6
                                          E. Elizondo, Doctoral Thesis, 2010
Scaling-up the DELOS methodology




                         E. Elizondo, Doctoral Thesis, 2010
Nanomedicine                                    Acknowledgments
Co-workers:
Dr. Nora Ventosa, Dr. Santi Sala, Dr. Maria Muntó, Dr. Mary Cano, Dr. Elisa
Elizondo, Alba Cordoba, Ingrid Cabrera, Dr. Miquel Gimeno, Daniel Villanueva,
Dr. Evelyn Moreno, Dr. Imma Ratera, Dr. César Diez-Gil, Witold Tatkiewicz

                                                         Financial support:
Collaborations:
• Prof. Marcel Besnard (LPCM-CNRS, France)
• Dr. Cristina Patiño (CNB-CSIC, Madrid)
• Dr. Jordi Esquena (CID-CSIC, Barcelona)
• Dr. Sylvane Lesieur (CNRS, France)
• Prof. Antoni Villaverde (UAB)
• Dr. Simó Schwartz (Hospital Vall D´Hebrón)
• Dr. Maria Blanco (U. Navarra)
• Dr. Maria Parajo (IBEC, Barcelona)
• Prof. Joel Bernstein (Israel)
• Dr. Dimitrios Stamou (Denmark)
• Dr. Eduardo Martínez Díaz, (CIGB, Cuba)
Acknowledgements
Molecular Nanoscience             Acknowledgments




Thank you for your attention.......

Más contenido relacionado

Destacado

Destacado (6)

Juan Luis Sanz Yagüe - Biocarburantes de 2ª Generación
Juan Luis Sanz Yagüe - Biocarburantes de 2ª GeneraciónJuan Luis Sanz Yagüe - Biocarburantes de 2ª Generación
Juan Luis Sanz Yagüe - Biocarburantes de 2ª Generación
 
Expoquimia 2011: Forum Biotech - Rosana Garcia
Expoquimia 2011: Forum Biotech - Rosana GarciaExpoquimia 2011: Forum Biotech - Rosana Garcia
Expoquimia 2011: Forum Biotech - Rosana Garcia
 
Justin Barry - Desarrollo pre-clínico y clínic de aplicaciones de nanomedicina
Justin Barry - Desarrollo pre-clínico y clínic de aplicaciones de nanomedicinaJustin Barry - Desarrollo pre-clínico y clínic de aplicaciones de nanomedicina
Justin Barry - Desarrollo pre-clínico y clínic de aplicaciones de nanomedicina
 
José Miguel Mulet - Biotecnología para hacer frente al cambio climático: la b...
José Miguel Mulet - Biotecnología para hacer frente al cambio climático: la b...José Miguel Mulet - Biotecnología para hacer frente al cambio climático: la b...
José Miguel Mulet - Biotecnología para hacer frente al cambio climático: la b...
 
Rosana García - Sistemas de Calidad en entornos regulados aplicados a instala...
Rosana García - Sistemas de Calidad en entornos regulados aplicados a instala...Rosana García - Sistemas de Calidad en entornos regulados aplicados a instala...
Rosana García - Sistemas de Calidad en entornos regulados aplicados a instala...
 
Blanca Suárez - Nanotecnología, un nuevo reto para la toxicología
Blanca Suárez -  Nanotecnología, un nuevo reto para la toxicologíaBlanca Suárez -  Nanotecnología, un nuevo reto para la toxicología
Blanca Suárez - Nanotecnología, un nuevo reto para la toxicología
 

Similar a Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics

Nano Based polymers and applications in Drugs Delivery
Nano Based polymers and applications in Drugs DeliveryNano Based polymers and applications in Drugs Delivery
Nano Based polymers and applications in Drugs Delivery
joyak
 
Nano technology and its releavance to drug designing 08072013
Nano technology and its releavance to drug designing 08072013Nano technology and its releavance to drug designing 08072013
Nano technology and its releavance to drug designing 08072013
Nani Karnam Vinayakam
 

Similar a Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics (20)

Expoquimia 2011: Nanomedicina - Jaume Veciana
Expoquimia 2011: Nanomedicina - Jaume VecianaExpoquimia 2011: Nanomedicina - Jaume Veciana
Expoquimia 2011: Nanomedicina - Jaume Veciana
 
liposomes and nanoparticles drug delivery system
liposomes and nanoparticles drug delivery systemliposomes and nanoparticles drug delivery system
liposomes and nanoparticles drug delivery system
 
Nanotechnology Based Drug Delivery
Nanotechnology Based Drug DeliveryNanotechnology Based Drug Delivery
Nanotechnology Based Drug Delivery
 
Michael Buschmann_Nanomedecine
Michael Buschmann_NanomedecineMichael Buschmann_Nanomedecine
Michael Buschmann_Nanomedecine
 
Role of nanoparticles as antiviral agents ppt
Role of nanoparticles as antiviral agents pptRole of nanoparticles as antiviral agents ppt
Role of nanoparticles as antiviral agents ppt
 
Nanotechnology Based Drug Delivery11
Nanotechnology Based Drug Delivery11Nanotechnology Based Drug Delivery11
Nanotechnology Based Drug Delivery11
 
1nanomedicine
1nanomedicine1nanomedicine
1nanomedicine
 
Nano Based polymers and applications in Drugs Delivery
Nano Based polymers and applications in Drugs DeliveryNano Based polymers and applications in Drugs Delivery
Nano Based polymers and applications in Drugs Delivery
 
application of nanaocarriers in delivery of biotechnologicals
application of nanaocarriers in delivery of biotechnologicalsapplication of nanaocarriers in delivery of biotechnologicals
application of nanaocarriers in delivery of biotechnologicals
 
Nanotechnology and its applications
Nanotechnology and its applicationsNanotechnology and its applications
Nanotechnology and its applications
 
Preparation and characterization of poly (2 hydroxyethyl methacrylate) (phema...
Preparation and characterization of poly (2 hydroxyethyl methacrylate) (phema...Preparation and characterization of poly (2 hydroxyethyl methacrylate) (phema...
Preparation and characterization of poly (2 hydroxyethyl methacrylate) (phema...
 
Nanotech Drug Delivery System: The Perfect Physio-Chemical deal for Biologica...
Nanotech Drug Delivery System: The Perfect Physio-Chemical deal for Biologica...Nanotech Drug Delivery System: The Perfect Physio-Chemical deal for Biologica...
Nanotech Drug Delivery System: The Perfect Physio-Chemical deal for Biologica...
 
parentral controlled drug delivery system
parentral controlled drug delivery systemparentral controlled drug delivery system
parentral controlled drug delivery system
 
Nano Technology by moun
Nano Technology by mounNano Technology by moun
Nano Technology by moun
 
NanotechnologyBasedDrugDelivery.ppt
NanotechnologyBasedDrugDelivery.pptNanotechnologyBasedDrugDelivery.ppt
NanotechnologyBasedDrugDelivery.ppt
 
Nano technology and its releavance to drug designing 08072013
Nano technology and its releavance to drug designing 08072013Nano technology and its releavance to drug designing 08072013
Nano technology and its releavance to drug designing 08072013
 
Nanobiotechnology,Nanotechnology,Biological pores
Nanobiotechnology,Nanotechnology,Biological poresNanobiotechnology,Nanotechnology,Biological pores
Nanobiotechnology,Nanotechnology,Biological pores
 
NANO TECHNOLOGY IN DRUG DELIVERY SYSTEM
NANO TECHNOLOGY IN DRUG DELIVERY SYSTEMNANO TECHNOLOGY IN DRUG DELIVERY SYSTEM
NANO TECHNOLOGY IN DRUG DELIVERY SYSTEM
 
Presentation on nanoparticles
Presentation on nanoparticlesPresentation on nanoparticles
Presentation on nanoparticles
 
Nanopharmacology
Nanopharmacology Nanopharmacology
Nanopharmacology
 

Más de ponenciasexpoquim11

Más de ponenciasexpoquim11 (20)

Manuel Romero - Nuevos materiales y fluidos térmicos para Centrales Solares T...
Manuel Romero - Nuevos materiales y fluidos térmicos para Centrales Solares T...Manuel Romero - Nuevos materiales y fluidos térmicos para Centrales Solares T...
Manuel Romero - Nuevos materiales y fluidos térmicos para Centrales Solares T...
 
Simó Schwartz - Avances en nanomedicina. La nanotecnología aplicada a la biom...
Simó Schwartz - Avances en nanomedicina. La nanotecnología aplicada a la biom...Simó Schwartz - Avances en nanomedicina. La nanotecnología aplicada a la biom...
Simó Schwartz - Avances en nanomedicina. La nanotecnología aplicada a la biom...
 
Lucía Roda Ghisleri - Development of GM crops in the EU. Key Issues for the A...
Lucía Roda Ghisleri - Development of GM crops in the EU. Key Issues for the A...Lucía Roda Ghisleri - Development of GM crops in the EU. Key Issues for the A...
Lucía Roda Ghisleri - Development of GM crops in the EU. Key Issues for the A...
 
José L. Adrio-Fondevila - Producción de bioplásticos por fermentation
José L. Adrio-Fondevila - Producción de bioplásticos por fermentationJosé L. Adrio-Fondevila - Producción de bioplásticos por fermentation
José L. Adrio-Fondevila - Producción de bioplásticos por fermentation
 
J.C Vidal - Uso de aptámeros en biosensors
J.C Vidal - Uso de aptámeros en biosensorsJ.C Vidal - Uso de aptámeros en biosensors
J.C Vidal - Uso de aptámeros en biosensors
 
Javier Amayra - Biotechnological Screening in Animal Cell Culture
Javier Amayra - Biotechnological Screening in Animal Cell CultureJavier Amayra - Biotechnological Screening in Animal Cell Culture
Javier Amayra - Biotechnological Screening in Animal Cell Culture
 
Gemma Fernández - Fabricación de medicamentos biológicos. Principios a consid...
Gemma Fernández - Fabricación de medicamentos biológicos. Principios a consid...Gemma Fernández - Fabricación de medicamentos biológicos. Principios a consid...
Gemma Fernández - Fabricación de medicamentos biológicos. Principios a consid...
 
Francesc Rabanal - Chemistry & Biotechnology
Francesc Rabanal - Chemistry & BiotechnologyFrancesc Rabanal - Chemistry & Biotechnology
Francesc Rabanal - Chemistry & Biotechnology
 
David Bueno - ¿De qué tenemos miedo? Reflexiones sobre la biotecnología
David Bueno - ¿De qué tenemos miedo? Reflexiones sobre la biotecnologíaDavid Bueno - ¿De qué tenemos miedo? Reflexiones sobre la biotecnología
David Bueno - ¿De qué tenemos miedo? Reflexiones sobre la biotecnología
 
Daniel Fernández - Nanogap’s approach to nanomaterials responsible management...
Daniel Fernández - Nanogap’s approach to nanomaterials responsible management...Daniel Fernández - Nanogap’s approach to nanomaterials responsible management...
Daniel Fernández - Nanogap’s approach to nanomaterials responsible management...
 
Ignasi Biosca - La biotecnología
Ignasi Biosca - La biotecnologíaIgnasi Biosca - La biotecnología
Ignasi Biosca - La biotecnología
 
Víctor M. González - Introducción a la tecnología de aptámeros y posibles apl...
Víctor M. González - Introducción a la tecnología de aptámeros y posibles apl...Víctor M. González - Introducción a la tecnología de aptámeros y posibles apl...
Víctor M. González - Introducción a la tecnología de aptámeros y posibles apl...
 
Óscar Salazar - Misión y visión en el diagnostic molecular
Óscar Salazar - Misión y visión en el diagnostic molecularÓscar Salazar - Misión y visión en el diagnostic molecular
Óscar Salazar - Misión y visión en el diagnostic molecular
 
Luis Alberto Solá Paños - El papel de la química en el desarrollo de la energ...
Luis Alberto Solá Paños - El papel de la química en el desarrollo de la energ...Luis Alberto Solá Paños - El papel de la química en el desarrollo de la energ...
Luis Alberto Solá Paños - El papel de la química en el desarrollo de la energ...
 
Luis Crespo - Centrales solares termoeléctricas: Desde la larga noche a una g...
Luis Crespo - Centrales solares termoeléctricas: Desde la larga noche a una g...Luis Crespo - Centrales solares termoeléctricas: Desde la larga noche a una g...
Luis Crespo - Centrales solares termoeléctricas: Desde la larga noche a una g...
 
Altarriba - Chemistry makes. Concentrated Solar Power (CSP) more successful
Altarriba - Chemistry makes. Concentrated Solar Power (CSP) more successfulAltarriba - Chemistry makes. Concentrated Solar Power (CSP) more successful
Altarriba - Chemistry makes. Concentrated Solar Power (CSP) more successful
 
Stefan Brändle - Espejos multilaminares de aluminio para aplicaciones solares...
Stefan Brändle - Espejos multilaminares de aluminio para aplicaciones solares...Stefan Brändle - Espejos multilaminares de aluminio para aplicaciones solares...
Stefan Brändle - Espejos multilaminares de aluminio para aplicaciones solares...
 
Scott Fogler - Globalization and Cooperation: Chemical Engineers Working to S...
Scott Fogler - Globalization and Cooperation: Chemical Engineers Working to S...Scott Fogler - Globalization and Cooperation: Chemical Engineers Working to S...
Scott Fogler - Globalization and Cooperation: Chemical Engineers Working to S...
 
Maria Burka - Chemical Engineering in the 21st Century
Maria Burka - Chemical Engineering in the 21st CenturyMaria Burka - Chemical Engineering in the 21st Century
Maria Burka - Chemical Engineering in the 21st Century
 
David Serrano - Towards a Sustainable Energy System: Technological Challenges
David Serrano - Towards a Sustainable Energy System: Technological ChallengesDavid Serrano - Towards a Sustainable Energy System: Technological Challenges
David Serrano - Towards a Sustainable Energy System: Technological Challenges
 

Último

FULL ENJOY Call Girls In Majnu Ka Tilla, Delhi Contact Us 8377877756
FULL ENJOY Call Girls In Majnu Ka Tilla, Delhi Contact Us 8377877756FULL ENJOY Call Girls In Majnu Ka Tilla, Delhi Contact Us 8377877756
FULL ENJOY Call Girls In Majnu Ka Tilla, Delhi Contact Us 8377877756
dollysharma2066
 
FULL ENJOY Call Girls In Mahipalpur Delhi Contact Us 8377877756
FULL ENJOY Call Girls In Mahipalpur Delhi Contact Us 8377877756FULL ENJOY Call Girls In Mahipalpur Delhi Contact Us 8377877756
FULL ENJOY Call Girls In Mahipalpur Delhi Contact Us 8377877756
dollysharma2066
 
Nelamangala Call Girls: 🍓 7737669865 🍓 High Profile Model Escorts | Bangalore...
Nelamangala Call Girls: 🍓 7737669865 🍓 High Profile Model Escorts | Bangalore...Nelamangala Call Girls: 🍓 7737669865 🍓 High Profile Model Escorts | Bangalore...
Nelamangala Call Girls: 🍓 7737669865 🍓 High Profile Model Escorts | Bangalore...
amitlee9823
 
Call Girls From Raj Nagar Extension Ghaziabad❤️8448577510 ⊹Best Escorts Servi...
Call Girls From Raj Nagar Extension Ghaziabad❤️8448577510 ⊹Best Escorts Servi...Call Girls From Raj Nagar Extension Ghaziabad❤️8448577510 ⊹Best Escorts Servi...
Call Girls From Raj Nagar Extension Ghaziabad❤️8448577510 ⊹Best Escorts Servi...
lizamodels9
 
Russian Call Girls In Rajiv Chowk Gurgaon ❤️8448577510 ⊹Best Escorts Service ...
Russian Call Girls In Rajiv Chowk Gurgaon ❤️8448577510 ⊹Best Escorts Service ...Russian Call Girls In Rajiv Chowk Gurgaon ❤️8448577510 ⊹Best Escorts Service ...
Russian Call Girls In Rajiv Chowk Gurgaon ❤️8448577510 ⊹Best Escorts Service ...
lizamodels9
 
Call Girls Electronic City Just Call 👗 7737669865 👗 Top Class Call Girl Servi...
Call Girls Electronic City Just Call 👗 7737669865 👗 Top Class Call Girl Servi...Call Girls Electronic City Just Call 👗 7737669865 👗 Top Class Call Girl Servi...
Call Girls Electronic City Just Call 👗 7737669865 👗 Top Class Call Girl Servi...
amitlee9823
 
Chandigarh Escorts Service 📞8868886958📞 Just📲 Call Nihal Chandigarh Call Girl...
Chandigarh Escorts Service 📞8868886958📞 Just📲 Call Nihal Chandigarh Call Girl...Chandigarh Escorts Service 📞8868886958📞 Just📲 Call Nihal Chandigarh Call Girl...
Chandigarh Escorts Service 📞8868886958📞 Just📲 Call Nihal Chandigarh Call Girl...
Sheetaleventcompany
 
Call Now ☎️🔝 9332606886🔝 Call Girls ❤ Service In Bhilwara Female Escorts Serv...
Call Now ☎️🔝 9332606886🔝 Call Girls ❤ Service In Bhilwara Female Escorts Serv...Call Now ☎️🔝 9332606886🔝 Call Girls ❤ Service In Bhilwara Female Escorts Serv...
Call Now ☎️🔝 9332606886🔝 Call Girls ❤ Service In Bhilwara Female Escorts Serv...
Anamikakaur10
 

Último (20)

FULL ENJOY Call Girls In Majnu Ka Tilla, Delhi Contact Us 8377877756
FULL ENJOY Call Girls In Majnu Ka Tilla, Delhi Contact Us 8377877756FULL ENJOY Call Girls In Majnu Ka Tilla, Delhi Contact Us 8377877756
FULL ENJOY Call Girls In Majnu Ka Tilla, Delhi Contact Us 8377877756
 
FULL ENJOY Call Girls In Mahipalpur Delhi Contact Us 8377877756
FULL ENJOY Call Girls In Mahipalpur Delhi Contact Us 8377877756FULL ENJOY Call Girls In Mahipalpur Delhi Contact Us 8377877756
FULL ENJOY Call Girls In Mahipalpur Delhi Contact Us 8377877756
 
Falcon Invoice Discounting platform in india
Falcon Invoice Discounting platform in indiaFalcon Invoice Discounting platform in india
Falcon Invoice Discounting platform in india
 
Nelamangala Call Girls: 🍓 7737669865 🍓 High Profile Model Escorts | Bangalore...
Nelamangala Call Girls: 🍓 7737669865 🍓 High Profile Model Escorts | Bangalore...Nelamangala Call Girls: 🍓 7737669865 🍓 High Profile Model Escorts | Bangalore...
Nelamangala Call Girls: 🍓 7737669865 🍓 High Profile Model Escorts | Bangalore...
 
Organizational Transformation Lead with Culture
Organizational Transformation Lead with CultureOrganizational Transformation Lead with Culture
Organizational Transformation Lead with Culture
 
Falcon Invoice Discounting: The best investment platform in india for investors
Falcon Invoice Discounting: The best investment platform in india for investorsFalcon Invoice Discounting: The best investment platform in india for investors
Falcon Invoice Discounting: The best investment platform in india for investors
 
Falcon Invoice Discounting: Empowering Your Business Growth
Falcon Invoice Discounting: Empowering Your Business GrowthFalcon Invoice Discounting: Empowering Your Business Growth
Falcon Invoice Discounting: Empowering Your Business Growth
 
Falcon Invoice Discounting: Unlock Your Business Potential
Falcon Invoice Discounting: Unlock Your Business PotentialFalcon Invoice Discounting: Unlock Your Business Potential
Falcon Invoice Discounting: Unlock Your Business Potential
 
Lundin Gold - Q1 2024 Conference Call Presentation (Revised)
Lundin Gold - Q1 2024 Conference Call Presentation (Revised)Lundin Gold - Q1 2024 Conference Call Presentation (Revised)
Lundin Gold - Q1 2024 Conference Call Presentation (Revised)
 
Call Girls Service In Old Town Dubai ((0551707352)) Old Town Dubai Call Girl ...
Call Girls Service In Old Town Dubai ((0551707352)) Old Town Dubai Call Girl ...Call Girls Service In Old Town Dubai ((0551707352)) Old Town Dubai Call Girl ...
Call Girls Service In Old Town Dubai ((0551707352)) Old Town Dubai Call Girl ...
 
Uneak White's Personal Brand Exploration Presentation
Uneak White's Personal Brand Exploration PresentationUneak White's Personal Brand Exploration Presentation
Uneak White's Personal Brand Exploration Presentation
 
Cheap Rate Call Girls In Noida Sector 62 Metro 959961乂3876
Cheap Rate Call Girls In Noida Sector 62 Metro 959961乂3876Cheap Rate Call Girls In Noida Sector 62 Metro 959961乂3876
Cheap Rate Call Girls In Noida Sector 62 Metro 959961乂3876
 
Call Girls Zirakpur👧 Book Now📱7837612180 📞👉Call Girl Service In Zirakpur No A...
Call Girls Zirakpur👧 Book Now📱7837612180 📞👉Call Girl Service In Zirakpur No A...Call Girls Zirakpur👧 Book Now📱7837612180 📞👉Call Girl Service In Zirakpur No A...
Call Girls Zirakpur👧 Book Now📱7837612180 📞👉Call Girl Service In Zirakpur No A...
 
Marel Q1 2024 Investor Presentation from May 8, 2024
Marel Q1 2024 Investor Presentation from May 8, 2024Marel Q1 2024 Investor Presentation from May 8, 2024
Marel Q1 2024 Investor Presentation from May 8, 2024
 
Call Girls From Raj Nagar Extension Ghaziabad❤️8448577510 ⊹Best Escorts Servi...
Call Girls From Raj Nagar Extension Ghaziabad❤️8448577510 ⊹Best Escorts Servi...Call Girls From Raj Nagar Extension Ghaziabad❤️8448577510 ⊹Best Escorts Servi...
Call Girls From Raj Nagar Extension Ghaziabad❤️8448577510 ⊹Best Escorts Servi...
 
Russian Call Girls In Rajiv Chowk Gurgaon ❤️8448577510 ⊹Best Escorts Service ...
Russian Call Girls In Rajiv Chowk Gurgaon ❤️8448577510 ⊹Best Escorts Service ...Russian Call Girls In Rajiv Chowk Gurgaon ❤️8448577510 ⊹Best Escorts Service ...
Russian Call Girls In Rajiv Chowk Gurgaon ❤️8448577510 ⊹Best Escorts Service ...
 
Call Girls Electronic City Just Call 👗 7737669865 👗 Top Class Call Girl Servi...
Call Girls Electronic City Just Call 👗 7737669865 👗 Top Class Call Girl Servi...Call Girls Electronic City Just Call 👗 7737669865 👗 Top Class Call Girl Servi...
Call Girls Electronic City Just Call 👗 7737669865 👗 Top Class Call Girl Servi...
 
Chandigarh Escorts Service 📞8868886958📞 Just📲 Call Nihal Chandigarh Call Girl...
Chandigarh Escorts Service 📞8868886958📞 Just📲 Call Nihal Chandigarh Call Girl...Chandigarh Escorts Service 📞8868886958📞 Just📲 Call Nihal Chandigarh Call Girl...
Chandigarh Escorts Service 📞8868886958📞 Just📲 Call Nihal Chandigarh Call Girl...
 
Dr. Admir Softic_ presentation_Green Club_ENG.pdf
Dr. Admir Softic_ presentation_Green Club_ENG.pdfDr. Admir Softic_ presentation_Green Club_ENG.pdf
Dr. Admir Softic_ presentation_Green Club_ENG.pdf
 
Call Now ☎️🔝 9332606886🔝 Call Girls ❤ Service In Bhilwara Female Escorts Serv...
Call Now ☎️🔝 9332606886🔝 Call Girls ❤ Service In Bhilwara Female Escorts Serv...Call Now ☎️🔝 9332606886🔝 Call Girls ❤ Service In Bhilwara Female Escorts Serv...
Call Now ☎️🔝 9332606886🔝 Call Girls ❤ Service In Bhilwara Female Escorts Serv...
 

Jaume Veciana - Chemistry: Contibutions to Clinical Therapeutics

  • 1. “NANOMEDICINA. La Última Frontera” Chemistry: Contributions to Clinical Therapeutics Jaume Veciana vecianaj@icmab.es www.expoquimia.com
  • 2. Nanomedicine 20th Century Research based on the discovery of new molecular entities (APIs) Analgesics Antibiotics Cancer treatment Keys: chemical synthesis, molecular and bioactivity characterization
  • 3.
  • 4. Nanomedicine Drug therapies based in targeted/controlled drug delivery systems Drug (therapeutic action) Polymeric capsule (pharmacological features) Nanocarrier Drug Delivery System Increasing the therapeutic efficiency of drugs….
  • 5.
  • 6.
  • 7.
  • 8.
  • 9. Nanomedicine Ideal Nanocarriers as Drug Delivery Systems (DDS) Multifunctional nanobjects Components Functions Container Protector Targeting Magnetic particle Diagnosis Drug Therapy Preparation of drug delivery systems at the nanoscale with scale-up methods P. Couvreur et al., Pharm. Res., 2006, 23, 1417-1450.
  • 10. Nanomedicine Novel Drug Delivery Systems Nanoparticles Polymeric-drug Vescicles Nanosuspensions conjugates Liposomes
  • 11. New Methods to Prepare Particulate Drug Delivery Systems Using compressed CO2 as a green solvent  Non-toxic  Non-flammable  Cheap  Easy separated from products  Enabling to control particles  Scale-up methods J.J. Watkins et al., Science 2004, J.D. Holmes et al. Chem. Eur. J. 2003
  • 12. New Methods to Prepare Particulate Drug Delivery Systems Using compressed CO2 as a green solvent Vescicles Liposomes Polymeric-drug conjugates Nanoparticles Nanosuspensions DELOS-family processes
  • 13.
  • 14.
  • 15. Processing of a drug for bronquial asthma Salmenterol xinafoate (SX) Drug for inhalatory asthma treatment OH NH2+ HO HO O OH CO2 - Bioavailable 12 Non-bioavailable % Volume 8 4 0 0.1 1 10 100 Particle Size (µm)
  • 16.
  • 17.
  • 18. Processing of an antibiotic for resistent infections Gentamicine loaded in bioadhesive nanostructured polymer as microparticles 2,5 µm Oral Delivery E. Elizondo et al, Pharm. Res., 2011, 28, 309-321
  • 19.
  • 20.
  • 21. Integration of Bioactive Principles into Nanovesicles Integration on surface & inside of the nanovesicles Compressed CO2 Integration Encapsulation
  • 22. Integration of Bioactive Principles into Nanovesicles Cholesterol CTAB CO2 small molecules Bioactive macromolecules Spin-off at PRUAB:
  • 23. Scaling-up the DELOS methodology 6 mL system 300 mL system 2000 mL system 25mL 1250mL 8300mL X 50 X6 E. Elizondo, Doctoral Thesis, 2010
  • 24. Scaling-up the DELOS methodology E. Elizondo, Doctoral Thesis, 2010
  • 25. Nanomedicine Acknowledgments Co-workers: Dr. Nora Ventosa, Dr. Santi Sala, Dr. Maria Muntó, Dr. Mary Cano, Dr. Elisa Elizondo, Alba Cordoba, Ingrid Cabrera, Dr. Miquel Gimeno, Daniel Villanueva, Dr. Evelyn Moreno, Dr. Imma Ratera, Dr. César Diez-Gil, Witold Tatkiewicz Financial support: Collaborations: • Prof. Marcel Besnard (LPCM-CNRS, France) • Dr. Cristina Patiño (CNB-CSIC, Madrid) • Dr. Jordi Esquena (CID-CSIC, Barcelona) • Dr. Sylvane Lesieur (CNRS, France) • Prof. Antoni Villaverde (UAB) • Dr. Simó Schwartz (Hospital Vall D´Hebrón) • Dr. Maria Blanco (U. Navarra) • Dr. Maria Parajo (IBEC, Barcelona) • Prof. Joel Bernstein (Israel) • Dr. Dimitrios Stamou (Denmark) • Dr. Eduardo Martínez Díaz, (CIGB, Cuba)
  • 26. Acknowledgements Molecular Nanoscience Acknowledgments Thank you for your attention.......