THIS CLASS IS IN BRIEF FOR UNDERGRADUATE UNDERSTANDING AND EXAMINATION PURPOSE

1. Dr.RAGHU PRASADA M S
MBBS,MD
ASSISTANT PROFESSOR
DEPT. OF PHARMACOLOGY
SSIMS & RC.

2. 1. Delayed release system
2. Extended release system
3. Site specific and receptor targeting
4. Rate controlled delivery system-Diffusion
systems –reservoir device, matrix device,
transdermal patches
5. Controlled release by stimulation
6. Target drug delivery system-nano particles
7. Colloidal drug carriers
8. Block copolymers
9. Liposomes as drug carriers
10. Ligand mediated targeting

3. 11. Resealed erythrocytes
12. Bioadhesives
13. Tissue engineered delivery systems
14. Stent implantation in angioplasty
15. Encapsulated cells
16. Refillable biohybrid artificial pancreas
17. Microchip delivery system
18. Micro fabricated micro needles
19. Powdered drug delivery

4. Repeated intermittent dosing of a drug
Ex. Enteric coated tablets
Extended release system- maintenance of therapeutic
blood and tissue levels of drug

5. Ocuserts –thin epithelial microunits
Ex. Pilocarpine occusert-gloucoma
Progestaserts- intrauterine
contraceptive device
Drug encapsulated in liposomes for intravenous
infusion –Amphotericin B

6. Inactive drug
Levodopadopamine
Procaine pencillin-G

7. Targeting a drug directly to a
certain biological location
Rate controlled delivery system
Diffusion systems –reservoir device,
matrix device, transdermal patches
Dissolution system-encapsulated,
matrix

8. Active ingredient is delivered across the skin for systemic distribution.
Example: transdermal scopolamine, transdermal nitroglycerine,

10.  Colloidal drug carriers
1. micro and nano
particles
2. macro molecular
complex
3. Liposomes and
niosomes
Ligand mediated
targeting
1. Vascular
compartment
2. Cellular compartment
3. Intracellular
4. Monoclonal
antibodies
5. Resealed erythrocytes

12. Gold absorbs more than iodine (3 x at 100 keV), enabling
higher contrast at lower X-ray dose and higher resolution.
Gold nanoparticles stay in the blood longer

14. 1. Vascular compartment
2. Cellular compartment
3. Intracellular
4. Monoclonal antibodies
5. Resealed erythrocytes

15. Nerve growth factors
Bone tissues
Resealed erythrocytes
Hypoosmotic lysis
Bioadhesives –mucoadhesives

16. ImmunisationPolyclonal antibodies
Single antigenic diterminants
Hybridoma technology
Murine MAbs- muromonab anti CD3
Chimeric MAbs- rituximab -NHL
Humanised MAbs- palivizumab

17. Micro mechanical DDS.
Example: Intanza influenza vaccine

18. Uses a tiny electrical current to promote flow of drug
(usually charged) through the skin.
Example: Dexamethasone.

19. It is a computerized syringe which delivers insulin into
the subcutaneous tissue every few minutes in tiny
amount 24 hours a day through a cannula placed in the
subcutaneous tissue.
Intermittently- GnRH
Continuously-Insulin

20. Delivers insulin subcutaneously without using needle.
Achieved by pressurizing the liquid through a small
orifice which creates high speed jet that can
penetrate the skin and underlying tissue.

21. It is a stent placed into narrowed, diseased peripheral
or coronary arteries that slowly release a drug to block
cell proliferation hence preventing fibrosis and re-
stenosis.