Pathogenesis Virus

Virus pathogenesis and genetics www.freelivedoctor.com

Viral pathogenesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Definitions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Cycle of infection Secondary sites Spread Entry Shedding Shedding Local Lymphatic Neuronal Blood (viremia) Primary site www.freelivedoctor.com

Entry ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Shedding, transmission ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Routes of entry and shedding www.freelivedoctor.com

Effects on cells ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Time course of infection; host response infection without spread: infection with spread: host response: www.freelivedoctor.com prodrome symptoms at secondary sites pro-drome symptoms at primary site healing innate immunity: interferon adaptive immunity: cellular, antibody inflammatory; immunopathogenesis 0 2 4 6 8 10 12 time (days)

Patterns of disease www.freelivedoctor.com

Mousepox pathogenesis www.freelivedoctor.com

Genetic principles ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Scope of virus genetics ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Clinical significance of genetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Mutation ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Mutant phenotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Temperature sensitivity No growth Grow virus Phenotype virus www.freelivedoctor.com wt wt wt high temp low temp

Temperature sensitive mutants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Temperature sensitivity wt 31 o C wt 40 o C ts 31 o C ts 40 o C www.freelivedoctor.com

Drug resistance wt -IBT wt +IBT mut -IBT mut +IBT www.freelivedoctor.com

Recombination and reassortment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

DNA virus recombination www.freelivedoctor.com

RNA virus recombination Copy choice www.freelivedoctor.com

RNA virus reassortment www.freelivedoctor.com

Summary: Pathogenesis & Genetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

For each virus, know: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Pathogenesis Virus

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