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Overview
Tuberculosis (TB)  Infectious disease caused by bacteria  ,[object Object],Usually spread from person to person through the air Leading infectious cause of morbidity and mortality globally ,[object Object]
Twice as common in males as in females
Four times as common in nonwhites as in whites,[object Object]
Incidence is highest in people who live in crowded, poorly ventilated, unsanitary conditions ,[object Object],Typical newly diagnosed patient with TB : single, homeless, nonwhite man Prognosis : with proper treatment, usually excellent 50%  mortality in strains of TB resistant to two or more of the major antitubercular agents
Pathophysiology and Etiology
Transmission Mycobacterium tuberculosis  ,[object Object]
Multiply at varying rates
Characterized as acid-fast aerobic organisms
Can be killed by heat, sunshine, drying, ultraviolet lightTransmitted by droplet nuclei, usually from within the respiratory tract of an infected person who exhales  ,[object Object],[object Object]
Pathology The bacilli of TB infect the lung, forming a tubercle (lesion) The tubercle: May heal, leaving scar tissue May continue as a granuloma, then heal, or be reactivated May eventually proceed to necrosis, liquefaction, sloughing, and cavitation
The initial lesion may disseminate tubercle bacilli  by extension to adjacent tissues by way of the bloodstream by way of the lymphatic system through the bronchi Extrapulmonary TB  ,[object Object]
can involve lymph nodes, bones, joints, pleural space, pericardium, CNS, GU tissue, peritoneum,[object Object]
Clinical Manifestations
Patient may be asymptomatic or may have insidious symptoms that may be ignored Constitutional symptoms ,[object Object]
Some patients have acute febrile illness, chills, flu-like symptoms,[object Object]
Diagnostic Evaluation
Sputum smear ,[object Object]
Obtain first morning sputum on 3 consecutive daysSputum culture ,[object Object],Chest X-ray  ,[object Object],[object Object]
Tuberculin skin test  ,[object Object]
inoculation of tubercle bacillus extract (tuberculin) into the intradermal layer of the inner aspect of the forearm
used to detect M. tuberculosis infection, past or present, active or inactive (latent)Nonspecific screening tests ,[object Object]
should not be used to determine if a person is infected,[object Object]
Management
Antitubercular therapy  ,[object Object]
at least 6 monthsAfter 2 to 4 weeks ,[object Object]
patient can resume normal activities while continuing to take medication,[object Object],[object Object]
Massive pulmonary tissue damage, with inflammation and tissue necrosis eventually leading to respiratory failure Bronchopleural fistulas from lung tissue damage, resulting in pneumothorax Hemorrhage, pleural effusion, pneumonia Other organ involvement with TB
Reactions to Drug Therapy INH ,[object Object]
CNS effects (dysarthria, irritability, seizures, dysphoria, diminished concentration)
lupus-like syndrome, hypersensitivity reactions, and monoamine poisoning (rarely occurring with consumption of some wines and cheeses)
Patients with pre-existing liver disease should be monitored closely.,[object Object]
peripheral neuritis and cutaneous reactions
Patients should have baseline visual acuity and color discrimination (Ishihara test) testing as well as monthly monitoringPyrazinamide ,[object Object],[object Object]
Rechallenge drugs sequentially every 3-4 days to find cause
Usual sequence is INH, rifampin, PZA, EMB, using the first line (most important) drug firstRifampin ,[object Object]
drug interactions with hormonal contraceptives, methadone, warfarin,[object Object]
Obtain history of exposure to TB. Assess for symptoms of active disease ,[object Object],Auscultate lungs for crackles During drug therapy, assess for liver dysfunction Question the patient about loss of appetite, fatigue, joint pain, fever, tenderness in liver region, clay-colored stools,  dark urine Monitor for fever, RUQ abdominal tenderness, nausea, vomiting, rash, persistent paresthesia of hands and feet. Monitor results of periodic liver function studies
Nursing diagnoses
Fatigue Imbalanced nutrition: Less than body requirements  Impaired gas exchange  Ineffective airway clearance  Ineffective coping  Ineffective therapeutic regimen management  Risk for injury
Key Outcomes
The patient will : ,[object Object]

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Tuberculosis-Medical and Nursing Managements

  • 1.
  • 3.
  • 4. Twice as common in males as in females
  • 5.
  • 6.
  • 8.
  • 9.
  • 11. Characterized as acid-fast aerobic organisms
  • 12.
  • 13. Pathology The bacilli of TB infect the lung, forming a tubercle (lesion) The tubercle: May heal, leaving scar tissue May continue as a granuloma, then heal, or be reactivated May eventually proceed to necrosis, liquefaction, sloughing, and cavitation
  • 14.
  • 15.
  • 16.
  • 17.
  • 19.
  • 20.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28. inoculation of tubercle bacillus extract (tuberculin) into the intradermal layer of the inner aspect of the forearm
  • 29.
  • 30.
  • 31.
  • 32.
  • 33.
  • 35.
  • 36.
  • 37.
  • 38. Massive pulmonary tissue damage, with inflammation and tissue necrosis eventually leading to respiratory failure Bronchopleural fistulas from lung tissue damage, resulting in pneumothorax Hemorrhage, pleural effusion, pneumonia Other organ involvement with TB
  • 39.
  • 40.
  • 41. CNS effects (dysarthria, irritability, seizures, dysphoria, diminished concentration)
  • 42. lupus-like syndrome, hypersensitivity reactions, and monoamine poisoning (rarely occurring with consumption of some wines and cheeses)
  • 43.
  • 44. peripheral neuritis and cutaneous reactions
  • 45.
  • 46. Rechallenge drugs sequentially every 3-4 days to find cause
  • 47.
  • 48.
  • 49.
  • 51. Fatigue Imbalanced nutrition: Less than body requirements Impaired gas exchange Ineffective airway clearance Ineffective coping Ineffective therapeutic regimen management Risk for injury
  • 53.
  • 54. consume adequate daily calories as required
  • 57. use support systems to assist with coping
  • 58. express an understanding of the illness and comply with treatment modalities
  • 59.
  • 60. Administer ordered antibiotics and antitubercular agents. Isolate the infectious patient in a quiet, properly ventilated room and maintain TB precautions. Provide diversional activities and check on him frequently. Make sure the call button is nearby. Place a covered trash can nearby, or tape a waxed bag to the bedside for used tissues. Tell the patient to wear a mask when outside his room. Visitors and health care personnel should also take proper precautions while in the patient's room. Make sure the patient gets plenty of rest. Provide for periods of rest and activity to promote health as well as conserve energy and reduce oxygen demand.
  • 61. Provide the patient with well-balanced, high-calorie foods, preferably in small, frequent meals to conserve energy. (Small, frequent meals may also encourage the anorexic patient to eat more.) Record the patient's weight weekly. If he needs oral supplements, consult with the dietitian. Watch for adverse reactions to the medications. Administer isoniazid with food. This drug can cause hepatitis or peripheral neuritis, so monitor levels of aspartateaminotransferase and alanineaminotransferase. To prevent or treat peripheral neuritis, give pyridoxine (vitamin B6) as ordered. If the patient receives ethambutol, watch for signs of optic neuritis; report them to the physician, who's likely to discontinue the drug. Check the patient's vision monthly, and give this medication with food.
  • 62. If the patient receives rifampin, watch for signs of hepatitis, purpura, and a flulike syndrome as well as other complications such as hemoptysis. Monitor liver and kidney function tests throughout therapy. Perform chest physiotherapy, including postural drainage and chest percussion, several times per day. Give the patient supportive care, and help him adjust to the changes he may have to make during his illness. Include the patient in care decisions, and let the family take part in the patient's care whenever possible.
  • 63. Community and home care considerations
  • 64. Improve ventilation in the home by opening windows in room of affected person, and keeping bedroom door closed as much as possible. Instruct patient to cover mouth with fresh tissue when coughing or sneezing and to dispose of tissues promptly in plastic bags. Discuss TB testing of people residing with patient. Investigate living conditions, availability of transportation, financial status, alcohol and drug abuse, and motivation, which may affect compliance with follow-up and treatment. Initiate referrals to a social worker for interventions in these areas. Report new cases of TB to public heath department for screening of close contacts and monitoring.
  • 66. Show the patient and family how to perform postural drainage and chest percussion. Also teach the patient coughing and deep-breathing exercises. Instruct him to maintain each position for 10 minutes and then to perform percussion and cough. Teach the patient the adverse effects of his medication, and tell him to report them immediately. Emphasize the importance of regular follow-up examinations, and instruct the patient and family members concerning the signs and symptoms of recurring TB. Stress the importance of faithfully following long-term treatment Advise anyone exposed to an infected patient to receive tuberculin tests and, if a positive reaction occurs, chest X-rays and prophylactic isoniazid.
  • 67. Warn the patient taking rifampin that the drug temporarily makes body secretions such as urine appear orange; reassure him that this effect is harmless. Caution the female patient taking oral contraceptives that the drug may be less effective while she's taking rifampin. Teach the patient the signs and symptoms that require medical assessment: increased cough, hemoptysis, unexplained weight loss, fever, and night sweats. Stress the importance of eating high-calorie, high-protein, balanced meals. Emphasize the importance of scheduling and keeping follow-up appointments.