AREB MEETING, AT PATTAYA,THAILAND FROM DEC. 6-7, 2011

1. What should be the time interval for a booster vaccination following re-exposure to rabies in previously vaccinated individuals ? Dr. M. K. Sudarshan , MBBS, MD [BHU], FAMS, Hon. FFPH [UK] Dean/Principal and Professor of Community Medicine President, Rabies in Asia Foundation Kempegowda Institute of Medical Sciences Bangalore, India Email: mksudarshan@gmail.com

7. Results Table 1. Antibody response to PEP immunization Note: 0.07% and 0.14% of rabies exposed persons had inadequate (<0.5IU/mL) RVNA response at the end of first and third month post-primary PEP, with or without RIG. Route of administration of Vaccine Enrolment/ Recruitment RIGs used Vaccinees with inadequate antibody response Cohorts Subjects /Patients Cohorts Subjects / Patients Day 28 Day 90 Day 180 Day 365 Total Intramuscular Intradermal 23 1314 12 636 0/1238 0/1051 3 /670 9/99 12 32 1481 17 690 2 /1268 4 /1366 3 /719 37/558 46 Total 55 2795 29 1326 2 /2506 4 /2417 6 /1389 46/657 58

8. Table 2. Antibody response to PrEP vaccination Note: All had adequate (≥0.5 IU per mL) RVNA response up to three months post primary PrEP vaccination. Route of administration of Vaccine Enrolment/ Recruitment Vaccinees with inadequate antibody response Cohorts Subjects /Patients Day 28 Day 90 Day 180 Day 365 Total Intramuscular 8 518 0/263 0/33 4 / 37 12/ 209 16 Intradermal 3 59 0/59 0/59 0/33 0/59 - Total 11 577 0/322 0/92 4 /70 12/268 16

19. Asian Biomedicine Vol 5, No 5, October 2011: 589-593

20. Thank you for your kind attention Taj Mahal, India