ESCAPE Trial Pediatric Nephrology

1. Corresponding Author Dr Franz Shaefer; Germany

4. MDRD Trial The Effects of Dietary Protein Restriction and Blood-Pressure Control on the Progression of Chronic Renal Disease Saulo Klahr, Andrew S. Levey, Gerald J. Beck, Arlene W. Caggiula, Lawrence Hunsicker, John W. Kusek, and Gary Striker for the Modification of Diet in Renal Disease Study Group N Engl J Med 1994; 330:877-884

9. To evaluate the antihypertensive, antiproteinuric and renoprotective efficacy of fixed-dose ACE inhibition in children with CKD stage II-IV To evaluate the renoprotective efficacy of intensified blood pressure control , targeting to low- normal 24h BP, in children receiving fixed-dose ACE inhibition Main Objectives of ESCAPE Trial E S C A P E

30. Kaplan Meier Curves

34. Updated version of Lewis and Ellis's original plot showing effect of β blockers on mortality. Lewis S , Clarke M BMJ 2001;322:1479-1480 ©2001 by British Medical Journal Publishing Group

35. Intervention group does better than control OR = 1.0 (no effect) Intervention group does worse than control

36. i. Probably a small study, with a wide confidence interval, crossing the line of no effect (OR = 1). Unable to say if the intervention works

37. ii. Probably a small study, wide confidence interval , but does not cross OR = 1; suggests intervention works but weak evidence

38. iii. Larger study, narrow confidence interval: but crosses OR = 1; no evidence that intervention works

39. iv. Large study, narrow confidence intervals: entirely to left of OR = 1; suggests intervention works

40. v. Small study, wide confidence intervals, suggests intervention is detrimental

41. vi. Meta-analysis of all identified studies: suggests intervention works.

54. ET-1 TGF  UPCR ** ** * *** *** * *** **