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The final goal of the project is to develop “BioBrick” for liposome produced by means of synthetic biology, that has a construct for disintegration embedded in its membrane. Xenobiotic packaged in a liposome is not part of pharmacodynamics since it is biologically unavailable. Which makes liposomes interesting candidates for universal drug delivery vectors. In our case, liposome disintegration is initiated by non-invasive sonic signal and carried out by a construct of a sensor and an active part embedded in a membrane. Sensor part of a construct is mechanoreceptor/mechanotransducer which activates protein representing the active part of a construct. After activation, active part carries out the dissolution of a compartmentalization function by means of total disintegration of vector or only membrane perforation. After an opening of a vector, previously packed xenobiotic becomes locally available with a high concentration in locale and thus high effect and low systemic concentration and thus smaller chance of side effect. This approach is very specific for both, time and space factors and at the same time has a very broad area of potential biomedical applications. Vector would be, in a hypothetical scenario of practical use in oncology, first packed with chemotherapeutics/biological drugs, administered intravenously and then medical staff would have an option of drug activation in specific locations. Activation is very precise and at the same time offers an option of easy switching among many different targets, for example between dominant tumor to many potential metastasis. Since location of activation is not tied to biomarker, but rather takes advantage of other rapidly developing medical technologies, vector remains universally and directly applicable for any patient and for a broad spectrum of pathologies in fields of oncology (chemotherapeutics/biological drugs and other payloads, like local immune response enhancers), autoimmune diseases (local immune suppressors, diabetes), parasitology (malaria drugs and plasmodium sporozoite), local pathologies (ulcer, trauma healing) . . .

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