Picornaviruses are a diverse family of viruses that includes poliovirus, rhinovirus, enterovirus, and others. They have a positive-sense RNA genome surrounded by an icosahedral capsid. The genome encodes a single polyprotein that is cleaved into structural and non-structural proteins. Replication is rapid, shutting down host cell protein synthesis. Transmission is usually fecal-oral or respiratory. Infections can cause a variety of illnesses depending on the virus, including poliomyelitis, hand foot and mouth disease, myocarditis, and the common cold. Diagnosis involves cell culture or PCR detection of the virus. Treatment is supportive and prevention includes vaccines for polio

1. Picornaviruses Eva L. Dizon M.D.,F.P.P.S

4. Classification + sense RNA viruses Porcine teschovirus Teschovirus Aichivirus Kobuvirus Equine rhinitis B virus Erbovirus Human parechovirus Parechovirus Hand foot and mouth virus O Aphtovirus Encephalomyocarditis virus Cardiovirus Human Rhinovirus Rhinovirus Hepatitis A Hepatoviruses Poliovirus, Enterovirus, Coxsackie,Echovirus Enteroviruses Picornaviridae Species Genus Family

9. Genome

11. Receptors Adhesion Molecule VCAM Vascular cell adhesion molecule 1 EMCV Immunoglobulin like CD 155 3 Poliovirus Regulator of complement activator Decay accelarating factor (DAF) ,CD55 6 Echovirus Integrin like VLA -2 2 Echovirus ICAM 1 3 Coxsackie A Low density lipoprotein receptor (LDLR) 10 Human rhinovirus Immunoglobulin like ICAM 1,CD 54 91 Human rhinovirus Description Receptors # of Serotypes Virus

13. Replication

17. Transmission Human Fecal Matter Hand Sewage Solid waste landfills Water supply Shellfish

19. Polio Pathogenesis

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