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Case 1
Suma, Kathryn, Patrick, Sid

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Patient History
 Seven year-old male
 Fatigue
 Muscle weakness
 Low endurance
 Loss of coordination
 Progressive difficulty walking

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Physical Examination
 Muscle loss & deformity
 Awkward gait
 Difficulty breathing

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Laboratory Results
 Cells have abnormal shape
 Cell division is abnormal
 Impaired intracellular movement of materials

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Diagnosis
 Malfunctioning organelle- the microfilaments

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Rationale
 Supports the cell
 Pulls apart chromosomes in
mitosis
 Moves materials inside the
cell
 Actin and myosin, two
microfilaments, cause muscle
contractions
 Causes abnormal cell shape
 Causes abnormal cell
division
 Faulty movement of cellular
materials
 Muscle loss and deformity
Cytoskeleton roles: Malfunctions cause: