for speech-language pathologist and audiologist

1. ALPORT SYNDROME

4. Alport syndrome is otherwise called as “single gene syndrome”

7. INCIDENCE The disorder is uncommon, and most often affects males. Women can transmit the gene for the disorder to their children, even if they have no symptoms. 74% of males are usually diagnosed as having the disease before age 6.

8. PREVALENCE Alport syndrome is approximately reported 1 of 5000 births.

14. Nephropathy

15. Hypertension in female patients

17. HEARING CHARACTRISTICS In Alport syndrome “BILATERAL PROGRESSIVE SENSORINEURAL HEARING IMPAIRMENT” Genetically based hearing impairment The hearing impairment occurs more frequently in patients and begins with gradual onset at about age 10. Loss of cochlear neurons and haircells Atrophy of striavascularis and spiral ligament and endolympatichydrops.

24. Heamodilusis (or) kidney transplantation may be necessary in severe cases of nephritics.

26. Fair to good for affected female patients

28. Thank you