Nano drug delivery

1. Nano Drug Delivery

2. IMPORTANCE OF NANOSIZE IN DRUG
DELIVERY
A new family of nanoscale
materials on the basis of
dispersed networks of cross-
linked ionic and nonionic
hydrophilic polymers is being
developed. Traditional
nanotechnology for drug
delivery mainly referred to
those nanoscale vehicles
which were mainly utilized to
improve the drug
bioavailability and minimize
the side effects of the drug by
holding or transporting the
drug molecules to the desired
locations.

3. NEW NANOSCALE PLATFORMS
Nanotools have been utilized for medical
diagnostics via:
Fluorescent Imaging
Magnetic Resonance Imaging (MRI)
Scanning Electron Microscopy (SEM)
Transition Electron Microscopy (TEM)
Atomic Force Microscopy (AFM)

4. VARIOUS ROUTES OF DRUG
DELIVERY
Oral Adminisration- Tablets, Capsules, Liquids,
Mixtures
Nasal Route- Nasal drops, Aerosol
Ophthalmic- Ointments, suspensions
Vaginal and Rectal Route- Soppositories
Parenteral Route- Injections

5. TARGETED DRUG DELIVERY
CONTINUED…
.
Targeted drug delivery is the most important goal of
pharmaceutical research and development.
Drug targeting is defined in the broadest sense, that is, to
optimize a drug’s therapeutic index by strictly localizing its
pharmacological activity to the site or organ of action.
This is an important distinction from the basic targeting
concept, where the specific drug receptor is the target and
the objective is to improve fit, affinity, and binding to the
specific receptor that ultimately will trigger the
pharmacological activity.

6. TARGETED DRUG DELIVERY
Drug targeting can be achieved by physical, biological,
or molecular systems that result in high concentrations of
the pharmacologically active agent at the
pathophysiologically relevant site.
If successful, the result of the targeting would be a
significant reduction in drug toxicity, reduction of the drug
dose, and increased treatment efficacy.

7. SPECIFIC ENZYMES AT THE TARGET ORGAN
Specific enzymes at the target organ activate the CDS to
drug (D) only at the site. In the periphery or rest of the
body, D is not formed due to the lack of activating enzymes
or unfavorable rate processes

8. DRUG TARGETING BY SOFT DRUGS
Soft Drugs are novel active drugs strategically designed
to undergo singular metabolic deactivation after they achieve
their therapeutic roles.
In many instances, these kinds of compounds are ideal for
producing specific action at the site of application without
affecting the rest of the body.
In the reversed targeting method using SDS, very
significant distributional differences for a drug can be
generated by involving drug metabolism in a retroactive
manner in the design.

9. VECTOR-MEDIATED DELIVERY
TO THE BRAIN
 The development of peptide-
based opioid analogs toward
clinically useful drugs is still
impeded by the limited access of
these substances to the central
nervous system (CNS) following
peripheral or systemic
administration
Various strategies are
evaluated for overcoming the
cerebrovascular endothelium,
which represents the
morphological substrate of the
BBB in vivo

10. ORAL PEPTIDE DELIVERY

11. ORAL PEPTIDE DELIVERY
Peptide drug delivery has been of considerable interest over
recent decades due in part to rapid developments in
biotechnology and peptide synthesis, as well as the unique
pharmacological activity of peptide drugs.
Among barriers for oral drug absorption, metabolism is
generally recognized as particularly significant for peptides
and peptide-type drugs.
For peptide-type drugs that have no intestinal instability and
are dosed below their solubility limit, the fraction of the dose
absorbed (not systemic availability) can be correlated with
intestinal membrane permeability

12. TRANSDERMAL DRUG DELIVERY SYSTEM
Nanotechnology plays a promising role in transdermal
applications
Drugs made of nanoparticles can efficiently delivered
the drugs directly into the epidermis

13. TRANSDERMAL APPLICATIONS
Transdermal applications include dendrimers which are
extensively used to deliver drugs, vaccines, and
chemotherapeutic agents for cancer therapy
Some of the dendrimer based bionano applications include:
gene delivery
targeted cancer therapy
in vivo diagnoses (MRI)
 antiinfective agent delivery
vaccine and peptide delivery