ttopstart is a European science and business consulting company that specialises in leveraging the impact of your European project through providing professional management, dissemination and exploitation services. ttopstart focuses on projects in the field of life sciences,healthcare and medical technology. Successful consortia have a sound scientific and non-scientific management framework. ttopstart provides professional non-scientific project management services as a full partner of your Horizon 2020 consortium. This allows you to focus on scientific management while ttopstart ensures that your project runs according to plan and fully in line with the EC grant agreement. Find out more on ttopstart.com

1. Dissemination and Exploitation
Services in Horizon 2020
Project
Management

2. 2Ontwerp: Studio Edwin de Boer

3. Project
Management
Dissemination and Exploitation
Services in Horizon 2020

4. ttopstart - Project Management
4
Professional
Horizon 2020 Project
Management
Successful consortia have a sound scientific
and non-scientific management framework.
ttopstart provides professional non-scientific
project management services as a full partner
of your Horizon 2020 consortium. This allows
you to focus on scientific management while
ttopstart ensures that your project runs
according to plan and fully in line with the
EC grant agreement.
“We like to dedicate our time to
the scientific activities within our
Horizon 2020 project. General project
management activities provided by
ttopstart are therefore ideal for the
performance of our Horizon 2020
consortium”
Dissemination and
Exploitation services
Horizon 2020 promises more breakthroughs
and discoveries by taking great ideas from
the lab to the market. Broad visibility
and (preparing) strong implementation
of your project's outcomes are therefore
key requirements. ttopstart specialises in
developing creative and detailed stakeholder-
targeted plans for dissemination and
exploitation of the proposed outcomes.
Our experience with commercialisation
translates directly into highly effective
outreach to all relevant stakeholders. Our
business strategy experience ensures that
we can design a streamlined, “lean” route
to market.
“The support of ttopstart in our
Horizon 2020 project has enabled
the start of a new venture to
commercialise research tools and
diagnostics”
ttopstart is a European science and business consulting company that
specialises in leveraging the impact of your European project through
providing professional management, dissemination and exploitation
services. ttopstart focuses on projects in the field of life sciences,
healthcare and medical technology.
Our services

5. 5
Professional project
management
ttopstart has the unique skills and expertise to facilitate the productivity of your
Horizon 2020 consortium. We remove the administrative burden associated with
(international) projects, allowing you to focus on the work plan. We offer an ex-
tended package of project management services, including:
• Setting up the project management administration;
• Developing a cloud-based environment
to share all project-related documents;
• Support with managing the budget;
• Coordination of annual project progress updates;
• Coordination of the activities for producing the deliverables, such as reports to
the EC.
• Organising consortium meetings;
• Liaison with the EC;
• Monitoring the risk management plan.
Our project management services are highly complementary to the activities of your
consortium and can be customised in close collaboration with the professionals in
your own organisation.
ttopstart offers full non-scientific project management
support as a partner of your Horizon 2020 consortium.
Our goal is to facilitate a productive working atmosphere.
Project Management
in Horizon 2020

6. ttopstart - Project Management
6
Project Management - application phase
Our services are implemented through a dedicated Consortium Management
Work Package, which will be part of your proposal. ttopstart offers the possibility
to contribute to the design of this Work Package in the Application Phase.
This ensures that your Horizon 2020 project gets an excellent score for the
Implementation criterion. This will be based on the best practices we have gained
in writing more than 100 EU projects. At project start, we will set up a virtual Project
Management Office (PMO) specified to the needs of the project and consortium.
Project Management – project phase
After the project has been granted, ttopstart will (co-)coordinate the Project
Management Work Package and will fulfil the task of the PMO. The PMO will set
up the material and guidelines to kickstart the project. During the project, the
PMO will function as a helpdesk for the project partners. Questions regarding
the non-scientific management of the project can be answered by the PMO.

7. 7
Figure 1: An example of the position of the PMO co-coordinated by ttopstart
Management Structure
WP 1 WP 3WP 2 WP 4 WP 5
Steering committee
PC, PM and vice-chair
Representatives
of participating
institutions
Management Team
PC and PM
WP Leaders
Project Management
Office
Advisory
Boards

8. ttopstart - Project Management
8
Dissemination
Dissemination activities
Dissemination activities should be carefully
designed and well-timed, in order to
maximise the visibility of your Horizon 2020
project to all relevant stakeholders. For
example, a drug development consortium
should disseminate the results to a range
of stakeholders including the scientific
community, the biotech/pharma industry,
patients and society. This has a number
of advantages, such as tapping into the
enthusiasm and needs of patients, preparing
market acceptance and paving the way for
commercialisation.
Each project has its own unique
dissemination strategy. ttopstart can
support you with developing a powerful
dissemination strategy and will coordinate
execution of the plan.
How does it work?
Application phase (optional)
In the application phase, ttopstart can
support you with the development of a
dedicated Work Package on Dissemination
and Exploitation in which the proposed
activities are described. The communication
and dissemination plan will consist of a
detailed description of which communication
and dissemination activities will be carried
out, as well as how and when.
The plan will be specified for each partner and
per target audience, including for example
(1) healthcare providers, (2) laboratory staff,
(3) the scientific community, (4) bio-pharma
industry, (5) public health agencies, (6)
national governments, (7) patients and (8)
the general public. For each stakeholder, the
communication objectives, interaction and
communication channels, and planning and
execution will be worked out in a separate
section. In particular, we will work out:
• Why do we want to communicate with
particular stakeholders?
• What do we wish to communicate?
• What do we wish to learn from our
stakeholders?
• When should we communicate?
• What are the best mechanisms for
effective communication?
• What are challenges to effective
communication?
Dissemination and Exploitation
ttopstart offers effective dissemination and exploitation activities to maximise
the impact of your Horizon 2020 project. This will contribute to the overall success
of the project, its visibility to relevant stakeholders and its promise to society.

9. 9
Horizon 2020 project phase
After the project has been granted, ttopstart
will start to carry out the activities described
in the dissemination plan. Different generic
communication and dissemination tools will
be developed including a project website,
newsletters, a unique animation (see
example here https://www.youtube.com/
watch?v=Tq980GEVP0Yz) of the project and
social media channels.
Furthermore, more targeted communication
and dissemination tools will be developed
and/or organised. These are designed to
target a specific audience with a clear
message. To take the example of drug
development, an industry-day or dedicated
workshop can be organised with companies
and/or venture capitalists active in this field.
The dissemination plans, tools and activities
will be set up and managed by ttopstart as
a partner (or as subcontractor for specific
activities) within your Horizon 2020 project.
These activities will fully comply with H2020
guidelines and EC regulations and will
incorporate best practices from ongoing EU
projects.
Figure 2: Basic example of dissemination strategy
and plans to reach stakeholders from a diagnostic project.
Stakeholders Impact Strategy to
maximise impact
Patients
Patients will benefit from a fast
and accurate diagnosis.
Inform patient organisations on
increase in time and quality of
diagnosis.
Clinicians
Clinicians will work with a pre-
selected patient group which
reduces workload and saves costs.
Inform through high-impact
publications and through KOLs
of clinical added value.
Diagnostic
Laboratories
The test can be commercialised
by diagnostic laboratories in the
near future.
Inform through personal meetings.
Health insurance
companies
Health insurance companies will
benefit from the diagnostic test
since it saves healthcare costs.
A cost-effectiveness study will
be conducted to provide reliable
evidence based for decision
making.
Pharma, biotech, CROs
Early stratification will enable
the selection of a highly suitable
group of patients for a clinical
trial.
A dedicated industry day will be
organised to explore potential
partnerships.
Scientific community
The diagnostic delivers novel
knowledge on biomarkers and
ther clinical utility.
Through high-impact publications
and presentations at conferences.

10. ttopstart - Project Management
10
Exploitation plans
The impact of Horizon 2020 is more
important than ever. Through broad
experience in business development for the
biotech/pharma and medtech industries,
ttopstart has the network and skills to
develop strong exploitation plans and
ensure commercialisation of valuable project
deliverables. Exploitation plans include a
technology transfer strategy, an intellectual
property policy, a market analysis and a
detailed business plan.
ttopstart also supports with a developing
clear plans for non-commercial utilisation of
valuable deliverables. We develop utilisation
plans which can be targeted to different
stakeholders such recommendations for
policy makers or pave the way towards
incorporation of the innovation into
treatment guidelines.
Market analysis and
Business Case
For deliverables that are valuable to society
or industry, a thorough market analysis will
be performed and a business case will be
set up to assess the commercial potential.
The market analysis will provide the founda-
tion for defining the business strategy. It will
consist of several optional components such
as: (A) a top-down landscape analysis, includ-
ing identification of business opportunities,
competitive developments and IP
potential, (B) a bottom-up market assess-
ment where we identify potential custom-
ers and unmet stakeholder needs and (C) a
customer examination for determining the
interest for buying IP or products. These stud-
ies will show if there is a solid business case
for commercialisation, including route-to-
market and knowledge protection strategy.
This will pave the way for the next step in the
commercialisation process: the development
of a business plan.
Exploitation
ttopstart is experienced in science and business consulting. We make sure
that market players become aware of project outcomes and interested in
commercialisation. We have co-founded more than 20 biotech and medtech
companies and were instrumental in initiating license agreements with industry,
all resulting from EU-funded projects.

11. 11
Business plan development in
Horizon 2020 projects
If the business case is positive, a comprehensive business plan will be formulated.
It will include a presentation of the product and concept, business and IP strategy,
business model, partners, market size and dynamics, technical and operational
planning, a SWOT analysis, and financial forecasts. The business plan will allow
you to commercialise and finance your findings.
ttopstart offers support for commercialisation. In the past, this has led to
the launch and growth of 7 companies in different EU countries such as
DualTpharma (www.dualtpharma.com) as a result from the FP7-METOXIA
project (www.metoxia.uio.no).
3.
Assay
development
6.
Post-market
activities
· 10-50 genes
· Kit format
· High sens/spec
4.
Clinical
validation
studies
2.
Marker
validation
1.
Biomarker
discovery
· Data collection
in EU wide
· Proof of concept
· GMP manufacturing
· Update CE-IVD mark
· Post-market validation studies
· SNP analysis
· Validated gene set
Retrospective and
prospective clinical
studies
5.
Launch
Figure 3: Example of diagnostic development plan in a H2020 business plan

12. ttopstart - Project Management
12
Follow-up funding after your
Horizon 2020 project
Successful Horizon 2020 projects generate innovative project deliverables.
The large majority of these deliverables need further investigation and/or
validation. The exploitation and utilisation plans form a good start for acquiring
follow-up funding within Horizon 2020, including Marie Curie, ERC and Research
and Innovation projects.
If your Horizon 2020 project results in a new company, there are several different
subsidies for Small Medium Enterprises (SMEs) that might propel the process,
including Eurostars and the SME Instrument.
Market research
Market report Business plan Financial plan
· Define oppertunity
· Identify unmet needs
· Identify key success criteria
· Competitive landscaping
· IP Landscaping
· Consult key opinion leaders
· Map Industrial needs
· Find strategic partners
· Etcetera
· Business model
· Route to market
· IP strategy
· Regulatory strategy
· Priduct development
· Corporate mission and vision
· Strategic partners
· Unique selling poits
· Action Plan
· Investment need
· Funding plan
· Revenue model
· Revenue planning
· Cash-flow prognosis
· Balance prognosis
· Profit & loss prognosis
· Risk & contingency plan
· Exit planning
Business strategy Financial planning
Figure 4: Business plan development process

13. 13
ttopstart combines science and business
professionals in life sciences, medical
technology and healthcare
ttopstart has been built on the unique
combination of science and business with
a focus on the sectors life sciences, medical
technology and healthcare. Our consultants
have a solid scientific background combined
with an extensive business skill set. This
is a key advantage for your Horizon 2020
application considering the increased EC
demands for translation of research, public
private partnerships and societal impact.
ttopstart consultants are involved in the
set up and management of large European
projects and have gained the necessary skills
and best practices to support these large
projects.
ttopstart has ample business
development expertise
ttopstart consultants work for academic
institutes, companies, governments, scientific
societies, and patient organisations. We
have gained the expertise and skill set
to communicate with a broad range of
different stakeholders. The dissemination
and exploitation services are also highly
synergised with our business development
activities, which is essential for successful
exploitation.
ttopstart supports over 50 biotech and
medtech spin-offs with business plan
development, market studies and fund raising
for innovative projects. We have developed
business plans with unique biotech
companies and large academic and medical
institutes and European consortia that have
resulted in financing rounds, licenses with
industrial partners and more than 20 new
start-up companies in the field different EU
countries.
ttopstart has gained experience in many
EU projects
ttopstart has acquired over €150 million
funding for clients over the last 3 years. The
experience includes numerous subsidies in
life sciences and medical technology such
as FP7/Horizon2020, European Research
Council, Eurostars, NIH, Erasmus Mundus
and IMI. ttopstart collaborates with dozens
of universities, academic hospitals and
companies in more than 10 European
countries.
Why ttopstart?
Our driver is the contribution to development of innovations that can strongly
advance healthcare, such as diagnostics and treatments for a wide range of diseases.

14. ttopstart - Project Management
14
Contact us
For more information please contact one of our consultants
or visit our website at www.ttopstart.com
Marije aan den Toorn, PhD - consultant
marije@ttopstart.com
Patrick de Boer MSc. - partner
patrick@ttopstart.com
+316 5389 7487
ir Jasper Levink - partner
jasper@ttopstart.com
+316 3434 2333
Jochem Bossenbroek MSc. - partner
jochem@ttopstart.com
+316 2244 2641

15. 15

16. www.ttopstart.com