Sortase A Inhibition By Ugi Products (Complex)

*D. Bulger, Oral Roberts University (ORU). C. Neylon, Rutherford Appleton Laboratory (RAL), UK. J. Gaikwad, Oral Roberts University. Oral Presentation Section J: Biochemistry D. Bulger, Biology and Chemistry Department, Oral Roberts University, Tulsa, OK 74171 507-475-1516

Overview ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Introduction: Sortase A Function ,[object Object],[object Object],[object Object],[object Object],[object Object]

Introduction: Sortase A Inhibition ,[object Object],[object Object],[object Object],[object Object],[object Object]

Introduction: Hex Protein Docking on Sortase A ,[object Object],[object Object],[object Object]

Introduction: Ugi 4 Component Reaction - U4CR ,[object Object],[object Object],[object Object],[object Object],[object Object]

Introduction: H 1 NMR Solubility Determination ,[object Object],[object Object],[object Object],[object Object],[object Object]

Aim and Hypothesis ,[object Object],[object Object],[object Object]

Materials and Methods: Assay Design ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Results/Discussion: Protein Purification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Fraction 7 Fraction 6 Fraction 5 Fraction 2 Fraction 3 Fraction 4 Fraction 1

Results/Discussion: NMR Solubility and U4CR ,[object Object],[object Object],[object Object],Ugi Product 62E

Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object]

Future Study ,[object Object],[object Object],[object Object],[object Object],[object Object]

Acknowledgements ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Sortase A Inhibition By Ugi Products (Complex)

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