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Aproximate dose-conversions-10-06-pharmacy-tidbits
1.
HMG CoA Reductase
Inhibitors (Statins) STATIN LDL Reduction Lovastatin (Mevacor) Lovastatin ER (Altoprev) *** Pravastatin (Pravachol) Simvastatin (Zocor) Fluvastatin (Lescol Lescol XL) *** Atorvastatin (Lipitor) *** Rosuvastatin (Crestor) *** 25-30% 20 mg 20 mg 20 mg 10 mg 40 mg 30-40% 40-80 mg 40 mg 40mg 20 mg 80 mg XL 10 mg 40-45% 80 mg (40 mg x 2) 60 mg 80 mg 40 mg or Vytorin 10/10 20 mg 5 mg 45-50% 80 mg or Vytorin 10/20 40 mg 10 mg 50-55% Vytorin 10/40 80 mg 20 mg >55% Please Note: Prescribing Zetia generally decreases LDL up to an additional 15% Vytorin 10/80 40 mg *** Statins not available generically in 2006 Be aware of potential drug interactions with Lovastatin and Simvastatin: Diltiazem, Verapamil, Cyclosporin, chronic erythromycin, Nefazodone, Protease inhibitors, Azole antifungals, Tacrolimus, Amiodarone. ** requires multiple tablets (often less cost effective) *** Calcium Channel Blockers not available generically • Omeprazole 40 mg capsule is not currently available generically; therefore use 2 of the 20 mg capsules. • Though it is reasonable to do so, prescribers often do not titrate Omeprazole dose beyond 20 mg daily • Ideally, patients should be educated about taking PPI 30 minutes before breakfast for best effect Calcium Channel Blockers Dihydropyridines Low Med High Max Daily Dose Amlodipine (Norvasc) *** 2.5mg 5mg 10mg 10mg Felodipine ER (Plendil) 2.5mg 5mg 10mg 10mg Isradipine CR (Dynacirc CR) *** 5mg 10mg 10-20mg ** 20mg ** Isradipine (Dynacirc) 2.5 mg bid 5 mg bid 10 mg Nicardipine SR (Cardene SR) *** 30mg bid 45mg bid 60mg bid ** 120mg Nicardipine (Cardene) 20mg tid 30mg tid 20 mg 2 tid ** 120mg Nifedipine ER (Procardia SR, Adalat CC) 30mg 60mg 90mg 120mg Nisoldipine (Sular) *** 20mg 30mg 40mg 60mg Non- dihydropyridines Low Med High Max Daily Dose Diltiazem ER 180mg 240mg 360mg 540mg** Verapamil SR 180mg 240mg 360mg 540mg** Proton Pump Inhibitors (Common doses are Bolded) Omeprazole (Prilosec or Prilosec OTC) Esomeprazole (Nexium) Lansoprazole (Prevacid) Pantoprazole (Protonix) Rabeprazole (Aciphex) 20mg daily 20mg daily 30mg daily 40mg daily 20mg daily 20mg bid or 40mg daily 40mg daily 30mg BID 40mg BID 20mg BID 40mg bid 80mg daily 60mg BID 80mg BID 40mg BID Approximate Dose Conversions (Updated 9/2006)
2.
Available ARB/Hydrochlorothiazide Combinations Avalide (150/12.5)
– (300/12.5) - (300/25) Benicar HCT (20/12.5) - (40/12.5) - (40/12.5) (40/25) Atacand HCT (16/12.5) - (32/12.5) Teveten HCT (600/12.5) - (600/25) Hyzaar (50/12.5) - (100/12.5) - (100/25) Micardis HCT (40/12.5) - (80/12.5) - (80/25) Diovan HCT (80/12.5) - (160/12.5) - (160/25) (320/12.5) - (320/25) ** Olmesartan (Benicar) lowers the DBP & SBP approximately 3-4 mmHg more than the corresponding dose of the other ARBs. Lowest dose of ARB’s are often for patients with volume or salt depletion. * requires pill splitting of ACE inhibitors ** requires multiple tablets (often less cost effective) *** Not available generically Angiotensin Receptor Blockers (ARB) Dose Low Medium High Irbesartan (Avapro) 75 mg 150 mg 300mg Olmesartan (Benicar) ** <20 mg (5 mg tablets available) 20 mg 40 mg Candesartan (Atacand) 4 to 8 mg 16 mg 32 mg Eprosartan (Teveten) 400 mg 600-800 mg Losartan (Cozaar) 25 mg 50-100 mg Telmisartan (Micardis) 20 mg 40 mg 80 mg Valsartan (Diovan) 40-80 mg 80-160 mg 320 mg Available ACE Inhibitor/Hydrochlorothiazide Combinations Benazapril/HCTZ (5/6.25) - (10/12.5) - (20/12.5) - (20/25) Captopril/HCTZ (25/15) - (25/25) - (50/15) - (50/25) Enalapril/HCTZ (5/12.5) - (10/25) Fosinopril/HCTZ (10/12.5) - (20/12.5) Lisinopril/HCTZ (10/12.5) - (20/12.5) - (20/25) Uniretic (Moexipril/HCTZ) (7.5/12.5) - (15/12.5) - (15/25) Quinapril/HCTZ (10/12.5) - (20/12.5) - (20/25) ACE Inhibitors Benazepril (Lotensin) Captopril (Capoten) Enalapril (Vasotec) Fosinopril (Monopril) Lisinopril (Prinivil, Zestril) Moexipril (Univasc) *** Perindopril (Aceon) *** Quinapril (Accupril) Ramipril (Altace) *** Trandolapril (Mavik) *** 5mg/day 2.5mg/day 2.5mg/day 3.75mg/day* 2mg/day 5mg/day 1.25mg/day 0.5mg/day * 10mg/day 6.25 mg TID 5mg/day 5mg/day 5mg/day 7.5mg/day 4mg/day 10mg/day 2.5mg/day 1mg/day 20mg/day 12.5mg TID 10mg/day 10mg/day 10mg/day 11.25mg/day * 6mg/day * 20mg/day 5mg/day 2mg/day 40mg/day 25mg TID 20mg/day 20mg/day 20mg/day 15mg/day 8mg/day 40mg/day 10mg/day 4mg/day 60mg/day ** 37.5mg TID * 30mg/day * 30mg/day * 30mg/day 22.5mg/day ** 12mg/day ** 60mg/day ** 15mg/day ** 6mg/day ** 80mg/day ** 50mg TID 40mg/day ** 40mg/day 40mg/day 30mg/day ** 16mg/day ** 80mg/day ** 20mg/day ** 8mg/day ** Approximate Dose Conversions (Updated 9/2006)
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